Neurotoxicity Research
Papers 1576
1 page of 158 pages (1,576 results)
Published on 2019in Neurotoxicity Research3.31
Rachael A. Dunlop , Gilles J. Guillemin49
Estimated H-index: 49
(Macquarie University)
The size and frequency of cyanobacterial blooms are increasing concomitantly with rising global temperatures and increased eutrophication, and this has implications for human health. Cyanotoxins, including L-BMAA, have been implicated in triggering neurodegenerative diseases such as ALS/PDC and Alzheimer’s disease. L-BMAA is a water-soluble non-protein amino acid that can bioaccumulate up the food chain, in a free- and protein-bound form. While some data exists on the degree of environmental enr...
Published on Jul 8, 2019in Neurotoxicity Research3.31
David R. Goulding5
Estimated H-index: 5
(NIH: National Institutes of Health),
Andrew D. Kraft7
Estimated H-index: 7
(NIH: National Institutes of Health)
+ 4 AuthorsG. Jean Harry24
Estimated H-index: 24
(NIH: National Institutes of Health)
Animal models have been used to study cellular processes related to human immunodeficiency virus-1 (HIV-1)-associated neurocognitive disorders (HAND). The HIV-1 transgenic (Tg) rat expresses HIV viral genes except the gag-pol replication genes and exhibits neuropathological features similar to HIV patients receiving combined antiretroviral therapy (cART). Using this rat, alterations in dopaminergic function have been demonstrated; however, the data for neuroinflammation and glial reactivity is c...
Published on Jul 2, 2019in Neurotoxicity Research3.31
Alika Sarkar (IITR: Indian Institute of Toxicology Research), Neeraj Rawat (IITR: Indian Institute of Toxicology Research)+ 1 AuthorsMahendra Singh25
Estimated H-index: 25
(IITR: Indian Institute of Toxicology Research)
Devastating motor features, lack of early prognostic tools, and absence of undeviating therapies call for an endeavor to develop biomarkers for Parkinson’s disease (PD). A biomarker is anticipated to help in timely and selective diagnosis as well as to hunt for an appropriate treatment option. Peripheral fingerprints can be used to assess the progression, distinguish PD from other related disorders, and monitor the efficacy of therapeutic options. From the last two decades, peripheral blood is c...
Published on Apr 23, 2019in Neurotoxicity Research3.31
Marcos Roberto de Oliveira23
Estimated H-index: 23
(UFMT: Universidade Federal de Mato Grosso),
Adriane Ribeiro Duarte1
Estimated H-index: 1
(UFMT: Universidade Federal de Mato Grosso)
+ 2 AuthorsCláudia Marlise Balbinotti Andrade7
Estimated H-index: 7
(UFMT: Universidade Federal de Mato Grosso)
Mitochondria are the major site of adenosine triphosphate (ATP) production in mammalian cells. Moreover, mitochondria produce most of the reactive oxygen species (ROS) in nucleated cells. Redox and bioenergetic abnormalities have been seen in mitochondria during the onset and progression of neurodegenerative diseases. In that context, excitotoxicity induced by glutamate (GLU) plays an important role in mediating neurotoxicity. Several drugs have been used in the treatment of diseases involving e...
Published on 2019in Neurotoxicity Research3.31
Cristina Ribas Fürstenau (UFABC: Universidade Federal do ABC), Izabel Cristina Custódio de Souza2
Estimated H-index: 2
(UFPEL: Universidade Federal de Pelotas),
Marcos Roberto de Oliveira23
Estimated H-index: 23
(UFMT: Universidade Federal de Mato Grosso)
Methylglyoxal (MG) is a dicarbonyl molecule exhibiting high reactivity and is a major responsible for glycation in human cells. Accumulation of MG is seen in certain diseases, including metabolic disturbances and neurodegeneration. Among other effects, MG promotes mitochondrial dysfunction, leading to bioenergetic decline and redox impairment in virtually any nucleated human cells. The detoxification of MG is dependent on the availability of reduced glutathione (GSH), a major antioxidant that is...
Published on May 4, 2019in Neurotoxicity Research3.31
Md. Sahab Uddin8
Estimated H-index: 8
(SEU: Southeast University),
Md. Tanvir Kabir2
Estimated H-index: 2
(BRACU: BRAC University)
+ 5 AuthorsGhulam Md Ashraf15
Estimated H-index: 15
(KAU: King Abdulaziz University)
Aging plays a significant role in the progression of vascular diseases and vascular dysfunction. Activation of the ADP-ribosylation factor 6 and small GTPases by inflammatory signals may cause vascular permeability and endothelial leakage. Pro-inflammatory molecules have a significant effect on smooth muscle cells (SMC). The migration and proliferation of SMC can be promoted by tumor necrosis factor alpha (TNF-α). TNF-α can also increase oxidative stress in SMCs, which has been identified to per...
Published on Jul 5, 2019in Neurotoxicity Research3.31
Zhe Wang (CSU: Central South University), Jia-Li Wu (CSU: Central South University)+ 8 AuthorsZhao-Lan Hu4
Estimated H-index: 4
(CSU: Central South University)
The immune status in the lymphatic system, especially mesenteric lymph nodes (MLNs), is critical to regulate the septic shock. Brain-derived neurotrophic factor (BDNF) in the enteric system has been reported to regulate enteric immunity. However, the role of its precursor, proBDNF, in the immune status of MLNs under sepsis condition is still unclear. This study aimed to characterize the expression pattern of proBDNF in MLNs after lipopolysaccharide (LPS) stimulation, and to investigate the assoc...
Published on Jun 3, 2019in Neurotoxicity Research3.31
Konrad A. Szychowski9
Estimated H-index: 9
Agnieszka Rombel-Bryzek + 1 AuthorsJan Gmiński3
Estimated H-index: 3
Throughout the lifetime of humans, the amount of stem cells and the rate of cell proliferation continue to decrease. Reactive oxygen species (ROS) are one among the many factors that promote stem cell aging. Both a decrease in the level of stem cells and increase in ROS production can lead to the development of different neurodegenerative diseases. This study was conducted to determine how the VGVAPG peptide, liberated from elastin during the aging process and under pathological conditions, affe...
Published on Jun 18, 2019in Neurotoxicity Research3.31
Anna Gądek-Michalska7
Estimated H-index: 7
(PAN: Polish Academy of Sciences),
Joanna Tadeusz5
Estimated H-index: 5
(PAN: Polish Academy of Sciences)
+ 1 AuthorsBugajski J17
Estimated H-index: 17
(PAN: Polish Academy of Sciences)
The nitric oxide (NO) pathway in the brain is involved in response to psychosocial stressors. The aim of this study was to elucidate the role of nNOS and iNOS in the prefrontal cortex (PFC), hippocampus (HIP), and hypothalamus (HYPO) during social isolation stress (IS), social crowding stress (CS), and a combined IS + CS. In the PFC, 3 days of CS increased iNOS but not nNOS protein level. In the HIP and HYPO, the levels of nNOS and iNOS significantly increased after 3 days of CS. In the PFC, IS ...
Published on Jul 11, 2019in Neurotoxicity Research3.31
Sachchida Nand Rai5
Estimated H-index: 5
(BHU: Banaras Hindu University),
Brijesh Kumar Singh1
Estimated H-index: 1
(Columbia University)
+ 6 AuthorsSurya Pratap Singh13
Estimated H-index: 13
(BHU: Banaras Hindu University)
Huntington’s disease (HD) is a fatal autosomal dominantly inherited brain disease caused by excessively expanded CAG repeats in gene which encodes huntingtin protein. These abnormally encoded huntingtin proteins and their truncated fragments result in disruption of cellular quality mechanism ultimately triggering neuronal death. Despite great efforts, a potential causative agent leading to genetic mutation in HTT, manifesting the neurons more prone to oxidative stress, cellular inflammation, ene...