Neurotoxicity Research
Papers 1670
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#1Hongyun Ji (Capital Medical University)H-Index: 1
#2Junxiang Ma (Capital Medical University)H-Index: 1
Last. Piye Niu (Capital Medical University)H-Index: 10
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To verify the role of PI3K-AKT-GSK3beta pathway during manganese (Mn)-induced cell death, apoptosis, related indicators were investigated. SH-SY5Y cells were directly exposed to different concentrations of MnCl2. Then, cell viability, apoptosis, necrosis rate, and cell cycle were detected by MTT, FITC Annexin V Apoptosis Detection Kit with PI and PI staining. Then, in two intervention groups, cells were preconditioned with agonist (PQQ) and suppressant (LY294002). The cell viability decreased wi...
#1Jinting Wang (ELU: Eastern Liaoning University)
#2Tianwei Wu (ELU: Eastern Liaoning University)
Last. Linlin Zheng (ELU: Eastern Liaoning University)
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This study investigated the influences of lanthanum (La) exposure on learning and memory and the expression of apoptosis-related proteins in offspring rats. Wistar female rats were randomly divided into a control group (NC) and 0.25%, 0.5% and 1.0% LaCl3 treatment groups, with eight per group. La dye was transmitted to offspring rats through parental blood circulation and breast milk before delactation and through water drinking after delectation. Offspring rats were killed at 14, 28 and 42 days...
#1Fakhroddin Aghajanpour (Shahid Beheshti University of Medical Sciences and Health Services)
#2Mahdi Eskandarian Boroujeni (Adam Mickiewicz University in Poznań)H-Index: 4
Last. Abbas Aliaghaei (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 4
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Tramadol is a synthetic analogue of codeine that is often prescribed for the treatment of mild to moderate pains. It has a number of side effects including emotional instability and anxiety. In this study, we focus on the structural and functional changes of prefrontal cortex under chronic exposure to tramadol. At the cellular level, the amounts of ROS and annexin V in PC12 cells were evidently increased upon exposure to tramadol (at a concentration of 600 muM for 48 h). To this end, the rats we...
#1Yu Liu (CSU: Central South University)H-Index: 1
#2Guang-Jing Zou (CSU: Central South University)H-Index: 1
Last. Fang-Fang Bi (CSU: Central South University)H-Index: 5
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Major depression disorder is one of the most common psychiatric disorders that greatly threaten the mental health of a large population worldwide. Previous studies have shown that endoplasmic reticulum (ER) stress plays an important role in the pathophysiology of depression, and current research suggests that brain-derived neurotrophic factor precursor (proBDNF) is involved in the development of depression. However, the relationship between ER and proBDNF in the pathophysiology of depression is ...
Excessive alcohol intake affects hippocampal function and neuronal communication through oxidative stress and mitochondrial impairment. Previous studies have suggested that the melanocortin system (MCS) plays an essential role in alcohol consumption and addiction. The MCS is a hypothalamic region involved in regulating inflammatory processes in the brain, and its pharmacological activation through the melanocortin-4 receptor (MC4R) reduces both alcohol consumption and the neuroinflammatory respo...
#1Alejandra Bernardi (UBA: University of Buenos Aires)H-Index: 2
#2Oscar V. Torres (San Diego Mesa College)H-Index: 2
Last. Veronica Bisagno (UBA: University of Buenos Aires)H-Index: 18
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Psychostimulant drugs, such as modafinil and caffeine, induce transcriptional alterations through the dysregulation of epigenetic mechanisms. We have previously demonstrated that acute modafinil administration is accompanied by multiple changes in the expression of histone deacetylases (HDACs) within the mouse medial prefrontal cortex (mPFC). Herein, we compared alterations in class IIa HDACs in the mouse mPFC and dorsal striatum (DS) after a single exposure to each psychostimulant. We treated m...
#1Ting Sun (Fourth Military Medical University)H-Index: 5
#2Li Luo (Fourth Military Medical University)H-Index: 1
Last. Qi Yang (Fourth Military Medical University)H-Index: 10
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Anxiety leads to a global decline in quality of life and increase in social burden. However, treatments are limited, because the molecular mechanisms underlying complex emotional disorders are poorly understood. We explored the anxiolytic effects of 8-O-acetyl shanzhiside methylester (8-OaS), an active component in Lamiophlomis rotata (L. rotata; Benth.) or Kudo, a traditional herb that has been shown to be effective in the clinical treatment of chronic pain syndromes in China. Two mouse anxiety...
#1Lei Guan (Capital Medical University)
#2Tianzuo Li (Capital Medical University)
Last. Jingwen Jiang (Capital Medical University)
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Clinical application of local anesthetic reagent, liposomal bupivacaine (BUP), may cause irreversible damage to human nerve system. In this study, we explored the functional role of long non-coding RNA (lncRNA) small nucleolar RNA host gene 16 (SNHG16) in BUP-induced neurotoxicity in SH-SY5Y cells. SH-SY5Y cells were treated with BUP in vitro, whose dose-dependent effects on cell viability and SNHG16 expression were explored. SNHG16 was upregulated in SH-SY5Y cells. The protection of SNHG16 upre...
#1Hussein Kadhem Al-Hakeim (University of Kufa)H-Index: 4
#2Asawer H. Najm (University of Kufa)
Last. Michael Maes (Deakin University)H-Index: 72
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Beta-thalassemia major patients are treated with repeated blood transfusions, which may cause iron overload, which in turn may induce immune aberrations, and show an increased risk of depression. The aim of the present study is to examine whether repeated blood transfusions, iron overload, and immune-inflammatory responses are associated with depression in children (6-12 years) with transfusion-dependent thalassemia (TDT). The Children's Depression Inventory (CDI), iron status (serum iron, ferri...
#1Junzhi Yi (ZJU: Zhejiang University)
#2Min Zhu (Hunan Normal University)
Last. Shuanglin Xiang (Hunan Normal University)H-Index: 13
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Formaldehyde (FA) is a common air pollutant. Exposure to exogenous FA can cause damage to the nervous system, such as learning and memory impairment, balance dysfunction, and sleep disorders. Excessive production of endogenous FA also causes memory impairment and is thought to be associated with Alzheimer's disease (AD). Tumor necrosis factor alpha-induced protein 1 (TNFAIP1) plays a crucial role in neurodevelopment and neurological diseases. However, the role of TNFAIP1 in FA-induced neurotoxic...
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