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Prostaglandins Leukotrienes and Essential Fatty Acids
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#1Xueyan Chen (JLU: Jilin University)H-Index: 2
#2Yixia Wu (JLU: Jilin University)H-Index: 3
Last.Guoliang Liu (JLU: Jilin University)H-Index: 2
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Abstract Objectives: Evaluate the effects of the single nucleotide polymorphism (SNP) rs3834458 in the fatty acid desaturase 2 gene (FADS2) on n-3 long-chain polyunsaturated fatty acid (LC-PUFA) levels using statistical meta-analysis. Methods: Literatures pertaining to the relationship between the SNP rs3834458 and LC-PUFA were retrieved from three electronic databases. Original information was analyzed using RevMan 5.3, including single statistics, test for heterogeneity, summary statistics and...
#1Wancheng Sun (Qinghai University)
#2Yihao Luo (Qinghai University)
Last.J. Thomas Brenna (University of Texas at Austin)H-Index: 36
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Abstract Background Branched chain fatty acids (BCFA) are bioactive food compounds and are well known to be essential components of human, cow and caprine milk. In Qinghai-Tibet plateau, yaks are domesticated in large numbers and their milk in addition to meat are commercially important to millions of Tibetans. Objective We tested the hypotheses that concentrations of BCFA in yak milk and manure differ between lactation periods and evaluated gene expression levels of certain genes involved in th...
Abstract There is a lack of studies about polymorphisms in FADS genes in pregnant women. We aimed to verify the interaction between three FADS gene polymorphisms (rs174561; rs174575; rs3834458) and dietary α-linolenic acid (ALA) or linoleic/α-linolenic acid ratio (LA/ALA) and plasma concentrations of omega-3 (n-3) PUFAs in pregnant women. Of the 250 women evaluated, the homozygous for the rs174561 and rs3834458 minor allele had high plasma ALA concentrations at the highest ALA and LA/ALA ratio t...
#1Christopher E. Ramsden (University of Adelaide)H-Index: 16
#2Zhi-Xin Yuan (NIH: National Institutes of Health)H-Index: 4
Last.Robert A. Gibson (University of Adelaide)H-Index: 58
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Abstract BACKGROUND Oxidized derivatives of polyunsaturated fatty acids, collectively known as oxylipins, are labile bioactive mediators with diverse roles in human physiology and pathology. Oxylipins are increasingly being measured in plasma collected in clinical studies to investigate biological mechanisms and as pharmacodynamic biomarkers for nutrient-based and drug-based interventions. Whole blood is generally stored either on ice or at room temperature prior to processing. However, the pote...
#1Helen M. Lindqvist (University of Gothenburg)H-Index: 8
#2Inger Gjertsson (University of Gothenburg)H-Index: 16
Last.Linnea Bärebring (University of Gothenburg)H-Index: 4
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Abstract Intake of blue mussels decreased disease activity in women with rheumatoid arthritis (RA) in the randomized cross-over MIRA (Mussels, inflammation and RA) trial. This study investigates potential causes of the decreased disease activity by analysing fatty acid composition in erythrocytes and plasma phospholipids and serum metabolites in the participants of the MIRA trial. Twenty-three women completed the randomized 2 × 11-week cross-over dietary intervention, exchanging one cooked meal ...
#1Pauline Léveillé (UdeM: Université de Montréal)
#2Inga-Sophia Knoth (UdeM: Université de Montréal)
Last.Guylaine Ferland (UdeM: Université de Montréal)H-Index: 24
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Abstract Background : Nutritional deficiencies often precede the diagnosis of cystic fibrosis (CF) in infants, and occur at a stage where the rapidly developing brain is more vulnerable to insult. While deficits in behavioral, cognitive development and social functioning have been reported in older CF children, their origins remain poorly understood. We seek to compare fat-soluble nutrient status of newly diagnosed non-screened infants with CF to that of healthy infants, and explore the associat...
#1Nobuaki Tanaka (Tohoku University)H-Index: 2
#2Hiroaki Yamaguchi (Tohoku University)H-Index: 18
Last.Nariyasu Mano (Tohoku University)
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Abstract The purpose of this study was to identify the transporter involved in the release of prostaglandin E2 (PGE2). In the present study, transport assays were conducted using membrane vesicles prepared from human lung adenocarcinoma A549 cells, thus enabling identification of the novel exporter present in A549 cells. PGE2 transport into A549 vesicles was higher in the presence of a proton (H+)-gradient, thus suggesting the involvement of PGE2-H+ symporter in PGE2 transport. Results from our ...
#1M. Slim (McGill University)
#2C. Ha (McGill University)
Last.Hope A. Weiler (McGill University)H-Index: 24
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Abstract Introduction Pentadecanoic (C15:0), heptadecanoic (C17:0) and trans-palmitoleic (t16:1n-7) fatty acids (FAs) are often used as biomarkers for dairy fat in adults. This study aimed to investigate the relationship between dairy product intake and these FAs in adolescents. Material and methods Healthy adolescents were randomized to one of three groups (Group 1: control; Group 2: consume 3 dairy servings/day; and Group 3: consume ≥ 4 servings/d). C15:0, C17:0 and t -C16:1n-7 were quantified...
#1Isabell Nessel (BU: Bournemouth University)
#2Minesh Khashu (BU: Bournemouth University)H-Index: 1
Last.Simon C. Dyall (University of Roehampton)H-Index: 11
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Abstract Donor human milk (DHM) is the recommended alternative, if maternal milk is unavailable. However, current human milk banking practices may negatively affect the nutritional quality of DHM. This review summarises the effects of these practices on polyunsaturated fatty acids, lipid mediators and antioxidants of human milk. Overall, there is considerable variation in the reported effects, and further research is needed, particularly with lipid mediators and antioxidants. However, to preserv...
#1Benoit Decouture (University of Paris)
#2Alexandre Leuci (University of Paris)
Last.Christilla Bachelot-Loza (University of Paris)H-Index: 3
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Abstract Discrepancies in preclinical studies of aspirin (ASA) antiplatelet activity in mouse models of bleeding and arterial thrombosis led us to evaluate commonly reported methods in order to propose a procedure for reliably measuring the effects of single dose ASA on mouse hemostasis. FVB and C57Bl6 mice received 100 mg/kg of ASA or vehicle orally 30 min or 3 h prior to investigate either hemostasis using the tail bleeding assay or carotid thrombosis induced by FeCl3, or to blood sampling for...
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