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Prostaglandins Leukotrienes and Essential Fatty Acids
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#2Mohammad Nasehi (IAU: Islamic Azad University)H-Index: 20
Last. Mohammad-Reza Zarrindast (Tehran University of Medical Sciences)H-Index: 40
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Fish oil (FO) is one of the richest natural sources of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). DHA is essential for brain functions and EPA has been approved for brain health. On the other hand, stathmin, TFEB, synaptophysin and LAMP-1 proteins are involved in synaptic plasticity, lysosome biogenesis and synaptic vesicles biogenesis. In this study, we aimed to investigate the effect of FO on social interaction memory in sleep-deprived rats with respect to level of stathmin, T...
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Pregnancy imposes increased nutritional requirements for the well being of the mother and fetus. Maternal lipid metabolism is critical for fetal development and long-term health of the offspring as it plays a key role in energy storage, tissue growth and cell signaling. Maternal fat composition is considered as a modifiable risk for abnormal lipid metabolism and glucose tolerance during pregnancy. Data derived from observational studies demonstrate that higher intake of saturated fats during pre...
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Abstract The blood fraction most commonly used for the assessment of fatty acid status is the plasma or serum phospholipids, since these provide a measure of long term dietary intake. However, conventional assays of fatty acid status in human plasma and serum require labour intensive, multi-step approaches, which are impractical for high-throughput analyses. This study reports a system capable of selectively separating plasma phospholipids from other lipid classes in just a few minutes. We demon...
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#1S Ahamed Ibrahim (NIN: National Institute of Nutrition, Hyderabad)
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#1Samuel Poirier (Laval University)H-Index: 3
#2Luc H. Boudreau (U de M: Université de Moncton)H-Index: 10
Last. Marc E. Surette (U de M: Université de Moncton)H-Index: 26
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ABSTRACT 5-lipoxygenase (5-LO), coded by the ALOX5 gene, is expressed in leukocytes and catalyzes the formation of leukotrienes, pro-inflammatory lipid mediators. Leukotrienes are central to immune responses, but are also involved in inflammatory disorders and 5-LO expression is associated with leukemia stem cell survival. It is therefore important to understand mechanisms that control 5-LO expression. This study investigated the control of 5-LO expression and leukotriene biosynthesis following ...
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#1Anil Sakamuri (NIN: National Institute of Nutrition, Hyderabad)H-Index: 1
#1Anil. SakamuriH-Index: 1
Last. Ahamed IbrahimH-Index: 3
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Abstract In the present study, we investigated the impact of substituting alpha-linolenic acid (ALA) or long-chain n-3 PUFA (eicosapentaenoic acid and docosahexaenoic acid) for linoleic acid and hence decreasing n-6:n-3 PUFA ratio on high-fructose diet-induced hypertriglyceridemia and associated hepatic changes. Weanling male Wistar rats were divided into four groups and fed with starch-diet (n-6:n-3 PUFA ratio 215:1) and high-fructose diets with different n-6:n-3 PUFA ratio (215:1, 2:1 with ALA...
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#1Maroua Mbarik (U de M: Université de Moncton)
#2Roody S Biam (U de M: Université de Moncton)
Last. Marc E. Surette (U de M: Université de Moncton)H-Index: 26
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Abstract Polyunsaturated fatty acids (PUFA) are important components of cellular membranes, serving both structural and signaling functions. Investigation of the functional responses of cells to various PUFA often involve cell culture experiments, which can then inform or guide subsequent in vivo and clinical investigations. In this study, human carcinoma and leukemia cell lines (MCF-7, HepG2, THP-1, Jurkat) were incubated for 3 days in the presence of up to 150 μM of exogenous arachidonic or ei...
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#1Alba García-Serrano (CSIC: Spanish National Research Council)H-Index: 4
Last. César Venero (Universidad Francisco de Vitoria)
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Abstract Cognitive decline is one of the hallmarks of aging and can vary from mild cognitive impairment to dementia to Alzheimer's disease. In addition to some lifestyle interventions, there is room for the use of nutraceuticals/functional foods as pharma-nutritional tools to lessen the burden of cognitive decline before it worsens. We previously reported the promising molecular actions of milk fat globule membranes and krill oil concentrates in a rat model of aging. In this study, we concentrat...
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Top fields of study
Endocrinology
Polyunsaturated fatty acid
Arachidonic acid
Fatty acid
Biochemistry
Diabetes mellitus
Biology