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Photodiagnosis and Photodynamic Therapy
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#1Giuseppe Greco (UniGe: University of Genoa)H-Index: 3
#2Simone Di Piazza (UniGe: University of Genoa)H-Index: 5
Last.Andrea Amaroli (UniGe: University of Genoa)H-Index: 12
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Abstract Background A large number of systemic diseases can be linked to oral candida pathogenicity. Virtually as the fungal infections, the global trend of invasive candidiasis has increased progressively of late. This tendency is often accentuated by increasing Candida albicans resistance to the most common antifungal medications. Photodynamic therapy (PT) is a promising alternative therapeutic approach for oral microbial infections. A new formulation of 5-aminolevulinic acid (5%ALA) in a ther...
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Abstract Oral leukoplakia (OL), a predominantly white change to the oral mucosa, is the most common potentially malignant lesion. Elimination of this condition, especially high risk OL, is advisable, even necessary as an attempt to avoid malignant transformation. Here we present three cases of OL successfully treated by ALA photodynamic therapy (PDT) following pretreatment with CO2 laser. After a series of one to three sessions the patients were monitored for 12 months. All lesions showed remiss...
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ABSTRACT Background To evaluate choriocapillary vascular density (CVD) in eyes with central serous chorioretinopathy (CSC) complicated by choroidal neovascularization (CNV), at baseline and after intravitreal injections (IVR) of Ranibizumab, using optical coherence tomography angiography (OCTA). Methods Twelve eyes of 12 patients were enrolled as group 1 and 12 unaffected fellow eyes formed group 2. Twelve eyes of 12 healthy controls were the control group. Results CVD in Group 1 did not differ ...
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Abstract Aim The purpose of this clinical study was to evaluate the adjunctive role of photodynamic therapy (PDT) in the improvement of clinical, microbiological and immunological parameters among adolescent patients undergoing fixed orthodontic treatment (FOT) during the period of 6 weeks. Materials and methods Fifty adolescent patients undergoing FOT were divided into following two groups; Group-A: PDT as an adjunct to full-mouth scaling (FMS) and, Group-B: FMS alone. Full-mouth plaque scores ...
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Abstract Platinum nanoparticles (Pt NPs) with properties including damage of DNA, enzmatic activity and possibility of light absorption in the biological range could find application as effective photosensitizers in photothermal anticancer therapy (PTT). The photothermal properties of Pt NPs depend on their shape, size and crystalline structure. Therefore, in this paper the effect of Pt NPs size on photothermal efficiency is determined. For this purpose, spherical, crystalline 80 nm PtI NPs and ...
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Abstract The purpose of this research was to examine biofilm (icaA, icaD and bap) and adhesin (clfA, fnbA, cna) genes, and also assess the genotypic and phenotypic antimicrobial resistance patterns of Staphylococcus aureus strains taken from wound specimens in Mardin, Turkey. A total of 220 wound specimens were investigated. The biofilm forming ability and resistance pattern for eleven antimicrobial agents were investigated by conventional and multiplex PCR methods. S. aureus were taken from 112...
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Abstract Purpose To evaluate the efficacy of antimicrobial photodynamic therapy (aPDT) and antimicrobial therapy on clinical and immunological outcomes of periodontal treatment in patients with periodontitis grade C and stage III or IV. Material and method The patients recruited in the current research fulfil the clinical case definition of periodontitis ‘grade C’ in terms of onset of the infection and stage III or IV that defines degree and severity of the disease. One-stage full-mouth ultrason...
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#1M. Ibrahim Khot (St James's University Hospital)H-Index: 2
#2Candice L. Downey (St James's University Hospital)H-Index: 6
Last.David Jayne (St James's University Hospital)H-Index: 40
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Abstract The ATP-binding cassette (ABC) superfamily G member 2 (ABCG2) transmembrane protein transporter is known for conferring resistance to treatment in cancers. Photodynamic therapy (PDT) is a promising anti-cancer method involving the use of light-activated photosensitisers to precisely induce oxidative stress and cell death in cancers. ABCG2 can efflux photosensitisers from out of cells, reducing the capacity of PDT and limiting the efficacy of treatment. Many studies have attempted to elu...
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Abstract Chromoblastomycosis (CBM) is a prevalent implantation fungal infection. Patients with CBM show chronic granulomatous hyperplasia with ulcers and exudation. It may cause incapacity for labor in some severe clinical forms and it is often refractory to antifungal therapies. There is no optimal treatment until now. Here we report a case of a 71-year-old male farmer with refractory CBM who was successfully treated with 5-aminolevulinic acid-based photodynamic therapy (ALA-PDT) and Itraconazo...
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Abstract We have recently reported the synthesis and characterization of gold-coated iron oxide nanoparticle and demonstrated such a nanoparticle (Au@Fe2O3 NP) was able to significantly enhance the lethal effects of photo-thermo-radiotherapy. The purpose of this study was to determine the mechanisms behind such an enhancement by investigating the changes induced in cancer cell viability, proliferation, and morphology as well as monitoring the alteration of some genes which play important role in...
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Top fields of study
Pathology
Dermatology
Photodynamic therapy
Photosensitizer
Medicine