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Cell Proliferation
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Papers 3066
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#1Yao Hao (WHU: Wuhan University)H-Index: 3
#2Yao Huang (WHU: Wuhan University)
Last. Danqing Lin (WHU: Wuhan University)
view all 14 authors...
OBJECTIVES Cryptococcus heimaeyensis S20 is found in Antarctica and can produce exopolysaccharides (CHEPS). Here, we explore the anti-tumour effects of CHEPS on non-small cell lung cancer (NSCLC). MATERIALS AND METHODS Cell viability was assessed by CCK8 and colony formation assays. Flow cytometry was used to analyse the cell cycle, cell apoptosis and reactive oxygen species (ROS). Cell autophagy was detected by EGFP-LC3 puncta assay, Lyso-Tracker Red staining and transmission electron microscop...
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#1Hongping Yu (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Pei Liu (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. You-Shui Gao (SJTU: Shanghai Jiao Tong University)H-Index: 12
view all 9 authors...
OBJECTIVES Osteonecrosis of the femoral head (ONFH), largely caused by alcohol abuse, is a refractory bone disease characterized by the impaired capacity of osteogenic differentiation of bone mesenchymal stem cells (BMSCs), as well as the disordered adipocyte accumulation. Chrysophanic acid (CPA) is a natural anthraquinone which has lipid regulation and bone protection capacity. The aim of this study was to reveal the potential function of CPA and the underlying mechanisms for the alcohol-induce...
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#1Yichi Xu (WMU: Wenzhou Medical College)H-Index: 1
#2Shuya Pan (WMU: Wenzhou Medical College)H-Index: 1
Last. Xueqiong Zhu (WMU: Wenzhou Medical College)H-Index: 14
view all 5 authors...
Cancer is one of most the significant threats to human health worldwide, and the primary method of treating solid tumours is surgery. Propofol, one of the most widely used intravenous anaesthetics in surgery, was found to be involved in many cancer-related pathophysiology processes, mainly including anti-tumour and minor cancer-promoting effects in various types of cancer. An increasing number of studies have identified that propofol plays a role in cancer by regulating the expression of multipl...
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#1Yimeng Wei (Peking Union Medical College)H-Index: 3
#2Leisheng Zhang (Peking Union Medical College)H-Index: 4
Last. Zhongchao Han (Peking Union Medical College)H-Index: 52
view all 10 authors...
OBJECTIVE Longitudinal studies have indicated VCAM-1+ mesenchymal stem/stromal cells (MSCs) as promising resources in regenerative medicine, yet the abundance in gene expression is far from adequate in the advantaged and "discarded" hUC-MSCs. Thus, high-efficient preparation and systematic dissection of the signatures and biofunctions of the subpopulation is the prerequisite for large-scale clinical applications. MATERIALS AND METHODS We primarily took advantage of a cytokine-based programming s...
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#1Xiaofan Lu (CPU: China Pharmaceutical University)H-Index: 5
#2Yu-Jie ZhouH-Index: 3
Last. Xiao-Bo LiH-Index: 2
view all 11 authors...
OBJECTIVES Due to the limited evaluation of the prognostic value of RNA processing genes (RPGs), which are regulators of alternative splicing events (ASEs) that have been shown to be associated with tumour progression, this study sought to determine whether colorectal cancer (CRC) could be further stratified based on the expression pattern of RPGs. MATERIALS AND METHODS The gene expression profiles of CRCs were collected from TCGA (training set) and three external validation cohorts, representin...
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#1Yan Liu (CAS: Chinese Academy of Sciences)H-Index: 5
#2Yehui Zhou (Soochow University (Suzhou))H-Index: 2
Last. Aihua Shi (CAS: Chinese Academy of Sciences)H-Index: 2
view all 12 authors...
OBJECTIVES Traditional cancer therapy and regular immunotherapy are ineffective for treating triple-negative breast cancer (TNBC) patients. Recently, chimeric antigen receptor-engineered natural killer cells (CAR NK) have been applied to target several hormone receptors on different cancer cells to improve the efficacy of immunotherapy. Furthermore, epidermal growth factor receptor (EGFR) is a potential therapeutic target for TNBC. Here, we demonstrated that EGFR-specific CAR NK cells (EGFR-CAR ...
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#1Lin Meng (JLU: Jilin University)H-Index: 2
#2Yueqi Zhao (JLU: Jilin University)H-Index: 4
Last. Qilin Liu (JLU: Jilin University)H-Index: 4
view all 11 authors...
OBJECTIVES Bone mesenchymal stem cells (BMSCs) play critical roles in tumour microenvironment. However, molecular mechanisms of how BMSCs to be recruited and effect subsequent tumour progression are poorly understood in oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS The distribution of CXCL8 was detected by immunohistochemical staining in OSCC tissues. The chemotaxis of conditioned media from different epithelial cells to BMSCs was examined by trans-well assay. Real-time quantitative...
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#1Ya Qi Cheng (SYSU: Sun Yat-sen University)
#2Shou Bi Wang (SYSU: Sun Yat-sen University)
Last. Qi Wan (SYSU: Sun Yat-sen University)H-Index: 1
view all 13 authors...
The tumour microenvironment (TME) plays a pivotal role in tumour fate determination. The TME acts together with the genetic material of tumour cells to determine their initiation, metastasis and drug resistance. Stromal cells in the TME promote the growth and metastasis of tumour cells by secreting soluble molecules or exosomes. The abnormal microenvironment reduces immune surveillance and tumour killing. The TME causes low anti-tumour drug penetration and reactivity and high drug resistance. Tu...
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#1Binglin Yue (NWAFU: Northwest A&F University)H-Index: 2
#2Haiyan Yang (NWAFU: Northwest A&F University)
Last. Hong Chen (NWAFU: Northwest A&F University)H-Index: 30
view all 9 authors...
Exosomes are membrane-bound extracellular vesicles that are produced in the endosomal compartment of most mammalian cell types and then released. Exosomes are effective carriers for the intercellular material transfer of material that can influence a series of physiological and pathological processes in recipient cells. Among loaded cargoes, non-coding RNAs (ncRNAs) vary for the exosome-producing cell and its homeostatic state, and characterization of the biogenesis and secretion of exosomal ncR...
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#1Sipin Zhu (WMU: Wenzhou Medical College)H-Index: 5
#2Yihe Li (WMU: Wenzhou Medical College)
Last. Jiake Xu (WMU: Wenzhou Medical College)H-Index: 46
view all 8 authors...
Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs), which encompasses family members, GDNF, neurturin (NRTN) and persephin (PSPN). ARTN is also referred to as Enovin or Neublastin, and bears structural characteristics of the TGF-β superfamily. ARTN contains a dibasic cleavage site (RXXR) that is predicted to be cleaved by furin to yield a carboxy-terminal 113 amino acid mature form. ARTN binds preferentially to receptor GFRα3, coupled to a ...
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