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Pediatric Drugs
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#1Yi-Wei Huang (NTU: National Taiwan University)
#2Tsen-Fang Tsai (NTU: National Taiwan University)
Therapeutic management of pustular psoriasis remains a challenge despite the rapid advance in psoriasis research and the development of drugs, especially biologics. Treatment guidelines have been established for pustular psoriasis, but no controlled studies are present for juvenile pustular psoriasis (JPP). Search of the literature reveals that current evidence of JPP treatment is limited to case reports and case series. Among the conventional drugs for JPP, oral retinoid is the most commonly us...
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#1Miriam Bornhorst (Children's National Medical Center)H-Index: 5
#2Eugene I. Hwang (Children's National Medical Center)
Pediatric brain tumors are the leading cause of cancer-related death in children. Recent advances in sequencing techniques, and collaborative efforts to encode the mutational landscape of various tumor subtypes, have resulted in the identification of recurrent mutations that may present as actionable targets in these tumors. A number of molecularly targeted agents are approved or in development for the treatment of various tumor types in adult patients. Similarly, these agents are increasingly b...
1 CitationsSource
#1Jean C. Dinh (Children's Mercy Hospital)
#2Chelsea Hosey-Cojocari (Children's Mercy Hospital)H-Index: 1
Last.Bridgette L. Jones (Children's Mercy Hospital)H-Index: 8
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Medical research in children typically lags behind that of adult research in both quantity and quality. The conduct of rigorous clinical trials in children can raise ethical concerns because of children’s status as a ‘vulnerable’ population. Moreover, carrying out studies in pediatrics also requires logistical considerations that rarely occur with adult clinical trials. Due to the relatively smaller number of pediatric studies to support evidence-based medicine, the practice of medicine in child...
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Aim The main burden of hypoxic-ischemic encephalopathy falls in low-income countries. 2-Iminobiotin, a selective inhibitor of neuronal and inducible nitric oxide synthase, has been shown to be safe and effective in preclinical studies of birth asphyxia. Recently, safety and pharmacokinetics of 2-iminobiotin treatment on top of hypothermia has been described. Since logistics and the standard of medical care are very different in low-resource settings, the aim of this study was to investigate safe...
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#1Holly L. Pacenta (UTSW: University of Texas Southwestern Medical Center)
#2Theodore W. Laetsch (UTSW: University of Texas Southwestern Medical Center)H-Index: 13
Last.Samuel John (UTSW: University of Texas Southwestern Medical Center)H-Index: 3
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The development of cluster of differentiation (CD)-19-targeted chimeric antigen receptor (CAR) T cells for the treatment of pre-B-cell acute lymphoblastic leukemia (B-ALL) is an exciting new advancement in the field of pediatric oncology. Tisagenlecleucel and axicabtagene ciloleucel are the first US FDA-approved CD19-targeted CAR T cells. While various different CD19 CAR T cells are in development, tisagenlecleucel is the only CAR T cell approved for pediatric patients. The multicenter phase II ...
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#1Alexis Horace (ULM: University of Louisiana at Monroe)H-Index: 2
#2Negar Golchin (UW: University of Washington)H-Index: 2
Last.Paul M. Bakaki (Case Western Reserve University)H-Index: 13
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Purpose The purpose of this study is to describe medications most commonly studied in pediatric polypharmacy research by pharmacologic classes and disease using a scoping review methodology.
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#1Rossana Baracco (WSU: Wayne State University)H-Index: 7
Severe hypertension in children may result in life-threatening complications. Although there has not been extensive research in this area in children, and recommendations are mostly derived from adult data, in the last few years, there have been more pediatric studies on the safety and effectiveness of antihypertensives. The clinical presentation of a child with severe hypertension varies and may be completely asymptomatic or include signs and symptoms of end-organ damage. Treatment of a child w...
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#1Paul V. Williams (UW: University of Washington)H-Index: 12
Chronic urticaria is an uncommon disorder in children but can present considerable morbidity, as well as frustration for the healthcare provider and parent. The prevalence is 0.1–0.3% but can vary considerably by country. Chronic spontaneous urticaria (no identifiable cause) is responsible for 70–80% of chronic urticaria, about half of this due to a subtype called chronic autoimmune urticaria identified by the presence of autoantibodies to IgE or the IgE receptor. Chronic urticaria that is trigg...
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#1Lauren A. Henderson (Boston Children's Hospital)H-Index: 11
#2Randy Q. Cron (Children's of Alabama)H-Index: 42
Macrophage activation syndrome (MAS), a form of secondary hemophagocytic lymphohistiocytosis, is a frequently fatal complication of a variety of pediatric inflammatory disorders. MAS has been most commonly associated with systemic juvenile idiopathic arthritis (sJIA), as approximately 10% of children with sJIA develop fulminant MAS, with another 30–40% exhibiting a more subclinical form of the disease. Children with other rheumatologic conditions such as systemic lupus erythematosus and Kawasaki...
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#1Emma van der Poest Clement (UU: Utrecht University)
#2Floor E. Jansen (UU: Utrecht University)H-Index: 25
Last.Jurriaan M. Peters (Boston Children's Hospital)H-Index: 17
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Tuberous sclerosis complex (TSC) is a genetic neurocutaneous disorder with epilepsy as a common and early presenting symptom. The neurological phenotype, however, is variable and unpredictable. Early and refractory seizures, infantile spasms in particular, are associated with a poor neurological outcome. Preliminary data suggests early and aggressive seizure control may mitigate the detrimental neurodevelopmental effects of epilepsy. For infantile spasms, vigabatrin is the first line of treatmen...
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