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Food and Chemical Toxicology
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Papers 12439
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Abstract 3-Fucosyllactose (3-FL), a highly abundant complex carbohydrate in human breast milk, functions as a prebiotic promoting early microbial colonization of the gut, increasing pathogen resistance and modulating immune responses. To investigate potential health benefits, 3-FL was produced by fermentation using a genetically modified E. coli K12 strain. The safety assessment of 3-FL included acute oral toxicity, in vitro and in vivo assessment of genetic toxicity, and a subchronic rodent fee...
#1Fengru Liu (Hefei University of Technology)H-Index: 1
#2Yiyin Zhang (Hefei University of Technology)
Last.Yingwang Ye (Hefei University of Technology)
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Abstract Ellagic acid (EA), a natural plant polyphenol, is usually used as a functional additive in variety of health foods. However, the potential toxicity of EA to human health should be paid enough attention. To clarify its biological toxicity in vivo, this study explored the binding mechanism of EA with bovine serum albumin (BSA) by means of spectroscopic approaches and molecular docking insimulative physiological conditions. The results showed that the mixture of BSA with EA could spontaneo...
#1Fang Du (Jiangsu University)H-Index: 1
#2Ting Zhao (Jiangsu University)H-Index: 21
Last.Liuqing Yang (Jiangsu University)H-Index: 25
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Abstract Polychlorinated biphenyls (PCBs) would do serious damage to multiple systems, while coplanar polychlorinated biphenyls, the most toxic member of the family, has been widely taken into consideration. In this study, ICR mice were fed with different doses of PCB126 to explore the underlying molecular mechanisms on immunotoxicity. The results showed that PCB126 caused immunosuppression as evidenced by inhibiting the ratios of thymus and spleen weights, changing the organizational structure ...
#1Gražina Slapšytė (Vilnius University)H-Index: 3
#2Veronika Dedonytė (Vilnius University)H-Index: 5
Last.Petras Rimantas Venskutonis (KTU: Kaunas University of Technology)H-Index: 31
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Abstract Genotoxicity of B. officinalis, G. officinalis, V. luteum and V. hirundinaria extracts, which demonstrated strong antioxidant capacity, was tested using chromosome aberration, sister chromatid exchange (SCE), cytokinesis-block micronucleus and alkaline single-cell gel electrophoresis (comet) assays in human lymphocytes in vitro and Ames Salmonella/microsome test. All tested extracts were not mutagenic in S. typhimurium strains TA98 and TA100 with and without metabolic activation and did...
#1Wei Yang (Jiangsu Normal University)H-Index: 3
#2Zhi-Kai Tian (Jiangsu Normal University)
Last.Chan-Min Liu (Jiangsu Normal University)H-Index: 21
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Abstract Fisetin, a natural flavonoid found in plants, fruits and vegetables, exerts anti-cancer, anti-oxidant, anti-inflammatory and anti-mitotic effects. The current study instigates the protective effect of fisetin against lead-induced synaptic dysfunction, neuroinflammation and neurodegeneration in mice, and explores its underlying mechanisms. The results indicated fisetin can significantly ameliorated behavioral impairments in Pb-treated mice. Fisetin inhibited Pb-induced the apoptotic neur...
#1Fatima BouhtitH-Index: 1
#2Mehdi NajarH-Index: 20
Last.Laurence LagneauxH-Index: 36
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Abstract Mesenchymal stromal cells (MSCs) represent a progenitor cell population with several biological properties. MSCs are thus of therapeutic interest for cell-based therapy but great efforts are needed to enhance their efficiency and safety. Herbal remedies and in particular their bioactive molecules, are potential candidates for improving human health. The novelty and originality of this study is to develop an efficient cell-therapeutic product by combining MSCs with medicinal plant derive...
Abstract Objective To investigate the role of inflammatory response, oxidative damage and changes of ATP-sensitive potassium channels (sKATP) in basilar artery (BA) smooth muscle cells (SMCS) of rabbits in subarachnoid hemorrhage (SAH) model. Methods Time course studies on inflammatory response by real-time PCR, oxidative process and function of isolated basilar artery after SAH in New Zealand White rabbits were performed. Basilar artery smooth muscle cells (BASMCs) in each group were obtained a...
#1Hung-Chih Lin (PRC: China Medical University (PRC))H-Index: 20
#2Chong-Kuei Lii (PRC: China Medical University (PRC))H-Index: 34
Last.Haw-Wen Chen (PRC: China Medical University (PRC))H-Index: 29
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Abstract Inflammation plays a key role in the development of cardiovascular disease (CVD), and docosahexaenoic acid (DHA) is recognized to fight against CVD. PPARα belongs to the nuclear hormone receptor superfamily and can interfere with inflammatory processes. Autophagy can degrade inflammasome proteins and counteract inflammation. Overexpression of intercellular adhesion molecule (ICAM) 1 in endothelial cells contributes to monocyte migration into the vascular intima. Here we investigated the...
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