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Hearing Research
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#1Celia Zhang (UB: University at Buffalo)H-Index: 4
#2Mitchell D. Frye (UB: University at Buffalo)H-Index: 4
Last. Bo Hua Hu (UB: University at Buffalo)H-Index: 24
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Abstract In industrial and military settings, individuals who suffer from one episode of acoustic trauma are likely to sustain another episode of acoustic stress, creating an opportunity for a potential interaction between the two stress conditions. We previously demonstrated that acoustic overstimulation perturbs the cochlear immune environment. However, how the cochlear immune system responds to repeated acoustic overstimulation is unknown. Here, we used a mouse model to investigate the cochle...
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#1Christian E. Stilp (University of Louisville)H-Index: 9
Abstract Perception of a sound is influenced by spectral properties of surrounding sounds. When frequencies are absent in a preceding acoustic context before being introduced in a subsequent target sound, detection of those frequencies is facilitated via an auditory enhancement effect (EE). When spectral composition differs across a preceding context and subsequent target sound, those differences are perceptually magnified and perception shifts via a spectral contrast effect (SCE). Each effect i...
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#1Brian C. J. Moore (University of Cambridge)H-Index: 79
Abstract Within the cochlea, broadband sounds like speech and music are filtered into a series of narrowband signals, each with a relatively slowly varying envelope (ENV) imposed on a rapidly oscillating carrier (the temporal fine structure, TFS). Information about ENV is conveyed by the timing and short-term rate of action potentials in the auditory nerve while information about TFS is conveyed by synchronization of action potentials to a specific phase of the waveform in the cochlea (phase loc...
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#2Olaf StrelcykH-Index: 5
Last. Pavel Zahorik (University of Louisville)H-Index: 16
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Abstract It has been hypothesized that noise-induced cochlear synaptopathy in humans may result in functional deficits such as a weakened middle ear muscle reflex (MEMR) and degraded speech perception in complex environments. Although relationships between noise-induced synaptic loss and the MEMR have been demonstrated in animals, effects of noise exposure on the MEMR have not been observed in humans. The hypothesized relationship between noise exposure and speech perception has also been diffic...
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#1Kate M. Brody (University of Melbourne)H-Index: 8
#2Amy Hampson (University of Melbourne)H-Index: 5
Last. Stephen O'Leary (University of Melbourne)H-Index: 46
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Abstract Visualisation of cochlear histopathology in three-dimensions has been long desired in the field of hearing research. This paper outlines a technique that has made this possible and shows a research application in the field of hearing protection after cochlear implantation. The technique utilises robust immunofluorescent labelling followed by effective tissue clearing and fast image acquisition using Light Sheet Microscopy. We can access the health of individual components by immunofluor...
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#1Seiji B. Shibata (Roy J. and Lucille A. Carver College of Medicine)
#2Matthew B. WestH-Index: 6
Last. Richard D. Kopke (University of Oklahoma Health Sciences Center)H-Index: 33
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Abstract Hair cells (HC) in the cochlea are responsible for transducing mechanical sound energy into neural impulses which lead to the perception of sound. Loss of these sensory cells is the most common cause of sensorineural hearing loss and spontaneous HC regeneration does not occur in mature mammals. Among the future potential treatment modalities is gene therapy, which is defined as the administration of either DNAs or RNAs as active pharmaceutical ingredients for inducing a clinically-benef...
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#1Catalina Valdes-Baizabal (University of Salamanca)H-Index: 2
#2Lorena Casado-Roman (University of Salamanca)H-Index: 1
Last. Manuel S. Malmierca (University of Salamanca)H-Index: 38
view all 4 authors...
Abstract The inferior colliculus is an auditory structure where inputs from multiple lower centers converge, allowing the emergence of complex coding properties of auditory information such as stimulus-specific adaptation. Stimulus-specific adaptation is the adaptation of neuronal responses to a specific repeated stimulus, which does not entirely generalize to other new stimuli. This phenomenon provides a mechanism to emphasize saliency and potentially informative sensory inputs. Stimulus-specif...
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#1Xiaopeng Liu (UB: University at Buffalo)H-Index: 2
#2Li Li (UB: University at Buffalo)
Last. Richard J. Salvi (UB: University at Buffalo)H-Index: 59
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Abstract Prolonged exposure to low-level noise has often been used scientifically as well as clinically to induce neuroplastic changes within the central auditory pathway in order to reduce central gain, suppress tinnitus and hyperacusis, and modulate different features of central auditory processing. A fundamental assumption underling these studies is that the noise exposure levels are so low that they have no effect on the neural output of the cochlea. Therefore, functional changes occurring i...
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#1David Sánchez-Benito (University of Salamanca)H-Index: 1
#2Miguel Angelo Hyppolito (USP: University of São Paulo)H-Index: 11
Last. Ricardo Gómez-Nieto (University of Salamanca)H-Index: 8
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Abstract Rodent models of audiogenic seizures, in which seizures are precipitated by an abnormal response of the brain to auditory stimuli, are crucial to investigate the neural bases underlying ictogenesis. Despite significant advances in understanding seizure generation in the inferior colliculus, namely the epileptogenic nucleus, little is known about the contribution of lower auditory stations to the seizure-prone network. Here, we examined the cochlea and cochlear nucleus of the genetic aud...
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#1Federico BolnerH-Index: 3
#2Sara MagitsH-Index: 1
Last. Jan WoutersH-Index: 50
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Abstract Cochlear implant users' limited ability to understand speech in noisy environments has been linked to the poor spatial resolution and the high degree of spectral smearing associated with the spread of neural excitation. A sound coding algorithm that aims to improve the spectro-temporal representation of the sound signal at the implanted ear by precompensating the electrical stimulation for the spread of excitation is presented in this study. The spread precompensation algorithm was inte...
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Top fields of study
Anatomy
Inner ear
Cochlea
Audiology
Biology