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Canadian Journal of Physiology and Pharmacology
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#2Chunhua Shao (Northumbria University)
Last. Junxian YuH-Index: 3
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This study aims to investigate the mechanisms through which Fructose Diphosphate (FDP) causes the anti-hypoxia and anti-fatigue effects, and improves learning and memory. Mice were divided into three groups: FDP-L,FDP-H and a control group. Acute toxic hypoxia induced by carbon monoxide, sodium nitrite and potassium cyanide, and acute cerebral ischemic hypoxia, were used to investigate the anti-hypoxia ability of FDP. The tests of rod-rotating, mouse-tail suspension and swimming endurance were u...
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#1Yaping Zhang (Capital Medical University)H-Index: 2
#2Nan Ding (Capital Medical University)
Last. Yaobin Zhu (Capital Medical University)H-Index: 6
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OBJECTIVE To identify the differential expressed miRNA during cerebral ischemia reperfusion injury (CIRI) process, thereby assisting in elucidating mechanism of CIRI development and providing potential target for CIRI prevention and treatment. METHODS 6 mice were randomized assigned to 2 groups:control group and CIRI model group. Global cerebral IR model by four-vessel occlusion was prepared among the CIRI model group. Brain tissues were collected after 48 hours after reperfusion. Total RNA was ...
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#1Elham Mohamadi-Jorjafki (SBUK: Shahid Bahonar University of Kerman)
#2Mehdi Abbasnejad (SBUK: Shahid Bahonar University of Kerman)H-Index: 13
Last. Maryam Raoof (KMU: Kerman Medical University)H-Index: 7
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This study examined the effects of delivery mode on the response to inflammatory pulpal pain and pain-induced changes in cognitive performance in adult rats. Experiments were done on rats born by vaginal or caesarean section (C-section) delivery. Dental pulp was irritated by intradental capsaicin (100 µg) application and then nociceptive scores were recorded for 40 min. Spatial and passive avoidance learning and memory were assessed using Morris Water Maze (MWM) and shuttle box tools, respective...
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#1Hang Xing (Xinxiang Medical University)
#2Sihan Xu (Xinxiang Medical University)
Last. Xiong Han
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Levetiracetam(LEV) has been demonstrated to improve cognitive function. Hippocampal theta rhythm (4-12 Hz) is associated with a variety of cognitively related behaviors, such as exploration in both humans and animal models. We investigated the effects of LEV on the theta rhythm in the rat hippocampal CA3 in hippocampal slices in vitro. We found that LEV increased the theta power in a dose-dependent manner. The increase in theta power can be blocked by GABAA receptor(GABAAR) or NMDA receptor(NMDA...
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Doxorubicin (Dox) is a highly efficient chemotherapeutic drug limited by its cardiotoxicity. Galectin-3 (Gal-3) overexpression is associated with several cardiovascular diseases. In this study, the in vivo models of Dox-treated rats and the in vitro model of Dox-treated H9C2 cells were used. Dox induced cardiac injury and dysfunction accompanied with the upregulation of Gal-3 at the end of the experiment. While inhibition Gal-3 with modified citrus pectin (MCP) exhibited dramatic improvement in ...
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#1Mohammed Maher Mehanna (Beirut Arab University)H-Index: 1
#2Souraya Domiati (Beirut Arab University)H-Index: 2
Last. Ahmed El Mallah (Alexandria University)H-Index: 1
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Since both morphine and tadalafil have been proven to exert some of their analgesic activity through modulation of the NO-cGMP pathway, the aim of the current study is to evaluate the pharmacologic interaction between tadalafil and morphine in order to decrease the dose of morphine and subsequently its side effects. The assessment was carried out through isobolographic analysis relative to ED50s of both morphine and tadalafil obtained by tail-flick test on BALB/c mice. Morphine and tadalafil ED5...
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#1Yasir Abdul (MUSC: Medical University of South Carolina)H-Index: 5
#2Weiguo Li (MUSC: Medical University of South Carolina)
Last. Adviye Ergul (MUSC: Medical University of South Carolina)H-Index: 30
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The endothelin (ET) system has been implicated to contribute to the pathophysiology of cognitive impairment and stroke in experimental diabetes. Our goals were to test the hypotheses that 1) circulating and/or peri-infarct ET-1 levels are elevated after stroke in both sexes and this increase is greater in diabetes, 2) ET receptors are differentially regulated in the diabetic brain, 3) brain microvascular endothelial cells (BMVEC) of female and male origin express the ETA receptor subtype, and 4)...
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Endocrinology
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Diabetes mellitus
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