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Behavioural Brain Research
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#1Satoru Mitazaki (Takasaki University of Health and Welfare)H-Index: 7
#2Osamu NakagawasaiH-Index: 25
Last.Takeshi Tadano (Kanazawa University)H-Index: 8
view all 9 authors...
Abstract Neonatal ventral hippocampal-lesioned (NVHL) rats have been shown to display neurochemical and behavioral abnormalities at adulthood, analogous to some of those seen in schizophrenia. Serotonergic neurotransmission is implicated the pathophysiology and treatment of schizophrenia. In this study, we evaluated possible role of serotonergic transmission is the behaviors of NVHL-lesioned rats. Bilateral lesions to the ventral hippocampus (VH) in rat pups were made using the excitotoxin ibote...
#1Andressa Soliani (UNIFESP: Federal University of São Paulo)
#2Silvia Megumi Kubota (UNIFESP: Federal University of São Paulo)
Last.J.C.S. Fernandes (UNIFESP: Federal University of São Paulo)H-Index: 19
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Abstract Histamine H3 receptors (H3R) have attracted interest of research groups as drug target to several CNS disorders. Data suggests that H3R antagonists exert neuroprotective, cognitive enhancement and antidepressant effects in rodents. The LINS01 compounds were reported as selective H3R antagonists, but their effects on memory, anxiety-like behaviour and spontaneous locomotor activity were not evaluated to date. Therefore, this study employed the plus-maze discriminative avoidance task (PM-...
#1Maxine De Butte (WT: West Texas A&M University)
#2Blake Gieseking (WT: West Texas A&M University)
Abstract Mild cognitive impairment (MCI) is characterized by a reduction in cerebral blood flow. Permanent ligation of the common carotid arteries (2VO) in the rat mimics the chronic decrease in CBF that characterizes aMCI. The current study determined if melatonin (a pineal hormone with neuroprotective properties) can attenuate the neurobehavioral consequences of 2VO using middle-aged female rats. Two weeks following 2VO or sham surgery, rats were tested on various learning and memory tasks. 2V...
#1Giovanna Mioni (UNIPD: University of Padua)H-Index: 9
#2Simon Grondin (Laval University)H-Index: 28
Last.Franca Stablum (UNIPD: University of Padua)H-Index: 9
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Abstract The present review includes transcranial magnetic and transcranial electric stimulation studies on time perception and shows that the neural processing of time requires the activity of wide range-distributed brain networks. Moreover, a critical discussion regarding non-invasive brain stimulation in the study of time processing is included to give the reader insights into the study of temporal processing in neuroscience. The cerebellum and auditory cortex seem most crucial when participa...
#1Tahani K. Alshammari (KSU: King Saud University)H-Index: 4
#2Hajar Alghamdi (KSU: King Saud University)
Last.Musaad A. Alshammari (KSU: King Saud University)H-Index: 6
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Abstract The mechanism underlying depression, anxiety, and stress-related psychiatric disorders is far from understood. The utilization of animal models of anxiety and stress can improve our knowledge of the pathology of these disorders as well as aiding in the identification of pharmacological therapeutic targets. The involvement of inflammation in the pathology of stress-related disorders is widely acknowledged. This study was therefore undertaken to assess depressive and anxiety-like behavior...
#1Jerzy Zieba (UNSW: University of New South Wales)H-Index: 1
#2Margaret J. Morris (UNSW: University of New South Wales)H-Index: 48
Last.Tim Karl (UNSW: University of New South Wales)H-Index: 33
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Abstract Some diets appear to have detrimental effects on schizophrenia symptoms. Neuregulin 1 (NRG1) is a risk gene for schizophrenia and a recently developed transgenic mouse model for Nrg1 type III demonstrates a schizophrenia-relevant phenotype. The current study evaluated the behavioural response of Nrg1 type III transgenic mice to high fat diet (HFD) to determine the potential interactive impact of diets and genetic risk factors on disease symptoms. Male and female Nrg1 III and control lit...
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