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Behavioural Brain Research
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#1Wendie N. Marks (U of C: University of Calgary)
#2Nadine K. Zabder (U of S: University of Saskatchewan)H-Index: 3
Last. John G. Howland (U of S: University of Saskatchewan)H-Index: 23
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Abstract The T-type calcium channel blocker, Z944, has been used as a pharmacological tool to assess T-type calcium channel function and examined for use in clinical trials. As Z944 affects fear learning and memory in a rodent model of absence epilepsy, it is important to determine the effect of Z944 on learning and memory in a non-disease outbred rodent strain. This study examined the dose-dependent effects (5 mg/kg, 10 mg/kg, i.p.) of acute systemic treatment with Z944 on the learning and memo...
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Abstract The activation of behaviour in a daily rhythm governed by the light cycle is a universal phenomenon among humans, laboratory mammals and other vertebrates. For mice, the active period is during the dark. We have quantified the increase in activity when the lights shut off (Light to Dark, L to D) using a generalized CNS arousal assay with 20 ms resolution, rather than traditional running wheels. Data analysis yielded the rare demonstration of an equation which precisely tracks this behav...
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#1Ignacio Lucas (University of Lleida)H-Index: 1
#2Patrícia Urieta (University of Lleida)
Last. Anton Aluja (University of Lleida)H-Index: 27
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Abstract The Prefrontal cortex (PFC) has been highly related to executive functions such as working memory (WM). This study assesses the activity of the PFC in performing the Sternberg WM task (ST) with three levels of difficulty (easy, medium and hard) using the near-infrared spectroscopy (fNIRS) technique. Participants were 43 young and healthy right-handed women. Nine WM task blocks were pseudo randomly presented, three for each difficulty task. The results showed that the participant's perfo...
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#1A.N. Expósito (UGR: University of Granada)
#2E. Morillas (UGR: University of Granada)H-Index: 2
Last. Milagros Gallo (UGR: University of Granada)H-Index: 20
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Abstract Age-related memory decline has been associated with changes in the medial prefrontal cortex (mPFC) function. In order to explore the role of mPFC in taste recognition memory, we have assessed mPFC c-Fos immunoreactivity in adult (5-month-old) and aged (24-month-old) male Wistar rats during the first (Novel), second (Familiar I), and sixth (Familiar II) exposure to a cider vinegar solution. Adult brains showed higher c-Fos expression in the ventral but not the dorsal region of mPFC durin...
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Abstract Dopamine (DA) in medial prefrontal cortex is crucial in extinction of aversive or appetitive experiences. Although attention has been mostly focused on the infralimbic area of prefrontal cortex, a role of the prelimbic (PL) area has been envisaged pointing to DA transmission in the extinction of drug conditioned behavior. Evidence shows that DA exerts its action also via both D1 and D2 receptor subtypes. Here we investigated the effects of D1 and D2 receptor agonist microinfusion in the...
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#1Johannes Walter (Heidelberg University)
#1Johannes Walter (Heidelberg University)
Last. Klaus Zweckberger (Heidelberg University)H-Index: 10
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Abstract Background Despite multiple experimental models of traumatic brain injury (TBI) being available, objective assessment of gait and motor function in rodents remains difficult; therefore, we studied the value of the CatWalk XT® gait analysis as an observer independent, automated method for outcome assessment in one of the most frequently used preclinical TBI model, the controlled cortical impact (CCI), in mice. Methods C57Bl/6 mice were subjected to either right parietal CCI or a sham pro...
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Abstract Accumulating evidence support the critical role of endogenous orexin system in modulation of various physiological functions. Among these, regulation of pain and wakefulness have extensively been investigated, however, by independent series of studies each focusing a distinct side. It is now well established that orexins induce potent analgesic effect via affecting their receptors within several specific brain structures. These mainly include locus coeruleus (LC), lateral paragigantocel...
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#1Dong-Xia LiH-Index: 1
#2Chang-Nan WangH-Index: 8
Last. Yu-Jian LiuH-Index: 8
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Abstract A relatively large number of diabetic patients risk complications of clinical depression that lead to poorer quality of life, however the precise mechanisms for diabetes-associated depression are not fully understood. Links between hyperglycemia-induced oxidative stress and NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome activation have been reported in the pathogenesis of diabetes. The present study aimed to elucidate the contribution of NLRP3-mediated apoptotic/p...
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#1Tim Stuckenschneider (University of the Sunshine Coast)H-Index: 2
#2Christopher D. Askew (University of the Sunshine Coast)H-Index: 20
Last. Stefan Schneider (University of the Sunshine Coast)H-Index: 21
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OBJECTIVE: The analysis of event-related potentials (ERPs) is a useful tool to differentiate between healthy older adults, and individuals with mild cognitive impairment (MCI). Less is known about the ERPs' sensitivity of differentiating between individuals with subjective cognitive impairment (SCI) and MCI, as early evidence indicates similar brain alterations between these two groups. In order, to establish tests that are sensitive to subclinical impairment, this study compared auditory evoked...
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#1Tatiana-Danai Dimitriou (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
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Abstract Background Behavioural and Psychiatric Symptoms in dementia (BPSD) tend to be a crucial and big problem in dementia. Anxiety several times remains under-diagnosed because it is often considered to be a psychological response to cognitive decline. As only the 10 % of patients were correctly treated, the pharmacological treatment should be well- considered. The aim of this study was to evaluate three non-pharmacological interventions for the treatment of anxiety in dementia. Methods A cro...
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Top fields of study
Endocrinology
Developmental psychology
Psychology
Neuroscience
Hippocampus