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British Journal of Ophthalmology
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#1Nate Jowett (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 12
#2Roberto Pineda (MEE: Massachusetts Eye and Ear Infirmary)H-Index: 23
Neurotrophic keratopathy (NK) is a devastating degenerative disease of the ocular surface, resulting in progressive corneal epithelial defects, ulceration, melting and in severe cases perforation.1 The disease results from dysfunction of trigeminal nerve afferents to the cornea; aetiologies include herpetic infection, ocular surgery, skull base tumours and surgery, brainstem cerebrovascular accidents, and congenital trigeminal nerve hypoplasia. The pathophysiology of NK encompasses loss of troph...
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#1S Singhhayreh (UI: University of Iowa)H-Index: 90
#2Sohan Singh Hayreh (UI: University of Iowa)H-Index: 88
Objective There has long been a great interest in neuroprotection therapy for ischaemic stroke and various types of optic neuropathies. In view of that, I reviewed the literature on the role of neuroprotection for non-arteritic anterior ischaemic optic neuropathy (NA-AION). Methods The review is based on a PubMed search of literature about the use of neuroprotectors in stroke and optic neuropathies and about current clinical trials of RPh201 and QPI-1007 in NA-AION. Results Several neuroprotecti...
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#1Vincent CamusH-Index: 8
#2Fabrice JardinH-Index: 31
Last.Hervé TillyH-Index: 74
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The recent publication by Hindso et al 1 confirmed the excellent outcome of extranodal marginal zone B-cell lymphoma of the ocular adnexa (OA-EMZL) with external beam radiation therapy (EBRT) as a stand-alone therapy, with an impressive 95% rate of 10-year disease-free survival. In the largest study to date of OA-EMZL patients from seven eyes cancer centres, 352 patients received EBRT as first treatment of localised disease with a median radiation dose of 26 Grays (Gy) (range 4–60 Gy) and the au...
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#1Pouya Alaghband ('KCL': King's College London)H-Index: 5
#2Elizabeth Galvis (St Thomas' Hospital)H-Index: 1
Last.Kin Sheng Lim ('KCL': King's College London)H-Index: 2
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Background The determinants of success of selective laser trabeculoplasty (SLT) in treatment-naive patients with open angle glaucoma (OAG) and ocular hypertension (OHT) have not been understood fully. Therefore, we have conducted this study to explore the predictors of success. Methods This is a retrospective review of a pre-existing database of patients who had received primary SLT at St Thomas’ Hospital, London, UK. Patients with OAG and OHT who had received primary 360° SLT treatment and had ...
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Aim Comparing outcomes after combined phacoemulsification, two iStents insertion and endocyclophotocoagulation (ECP) versus phacoemulsification-iStents alone. Methods This is a longitudinal retrospective 12 months study in eyes with ocular hypertension or early-to-moderate open angle glaucoma. Level of disease, intraocular pressure (IOP) and tolerance of glaucoma medication were considered before planning surgery. Best-corrected visual acuity (BCVA-logMAR), IOP (mm Hg), number of medications wer...
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#2Bruna Gil Ferreira (State University of Campinas)H-Index: 3
Last.Alexandre Soares Castro Reis (State University of Campinas)H-Index: 1
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Aims To evaluate contrast sensitivity (CS) in patients with advanced glaucomatous visual field damage, and to compare two clinical CS tests. Methods This was a cross-sectional test–retest study. Twenty-eight patients with open-angle glaucoma, visual acuity (VA) better than 20/40 and visual field mean deviation (MD) worse than −15 dB were enrolled. Patients underwent VA, visual field and CS testing with the Pelli-Robson (PR) chart and the Freiburg Visual Acuity and Contrast Test (FrACT). Retest m...
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Aim To comprehensively examine the association between kidney function and primary open angle glaucoma (POAG) in a large consortium of multiple Asian population-based studies. Methods 28 925 participants (57 340 eyes) from 9 population-based studies (from China, Hong Kong, India, Korea, Russia, Singapore) of the Asian Eye Epidemiology Consortium were included. Across all studies, POAG was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. Estim...
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Aims To evaluate the accuracy of the ISNT rule (I=inferior, S=superior, N=nasal, T=temporal) and its variants with neuroretinal rim width and retinal nerve fibre layer (RNFL) thickness measurements differentiating normal from glaucomatous eyes. Methods The diagnosis accuracy of the ISNT rule and its variants was evaluated in a population-based study. Neuroretinal rim widths were measured on monoscopic optic disc photographs with an image-processing program. RNFL thickness measurements were obtai...
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Aims Studying the relationship between retinal vessel diameter (RVD) with (1) macular thickness and volume, (2) retinal nerve fibre layer (RNFL), (3) ganglion cell-inner plexiform layer (GC-IPL) and (4) optic nerve head (ONH) in a population cohort of middle-aged Caucasians. Methods We collected data from 3070 individuals. We used a semiautomated computer-assisted programme to measure central retinal arteriolar equivalent and central retinal venular equivalent. Macular and ONH parameters were as...
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#1Jennifer R Evans (Lond: University of London)H-Index: 32
Last.Martin Leyland (Royal Berkshire NHS Foundation Trust)H-Index: 1
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Background/aims To describe and summarise the outcomes reported in randomised controlled trials of multifocal versus monofocal intraocular lenses in cataract surgery. Methods We identified all randomised controlled trials of multifocal versus monofocal lenses in a Cochrane review (last search date June 2016). We extracted and summarised data on all outcomes reported using the framework of domain, measurement, metric and method of aggregation. Results All studies collected data on distance and ne...
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