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Objectives: Inhaled corticosteroids (ICS) reduce exacerbation rates and the decline in lung function in people with chronic obstructive pulmonary disease (COPD). There is evidence that smoking causes ‘steroid resistance’ and thus reduces the effect of ICS. This systematic review aimed to investigate the effect of smoking on efficacy of ICS in COPD in terms of lung function and exacerbation rates. Design: Systematic review Data Sources: An electronic database search of PubMed, Ovid Medline, Ovid ...
#2Lillemor Lundin-Olsson (Umeå University)H-Index: 28
Last. Marlene Sandlund (Umeå University)H-Index: 7
view all 7 authors...
#1Mélanie BérubéH-Index: 7
#2Lynne MooreH-Index: 35
Last. Caroline L. Côté (Laval University)H-Index: 7
view all 11 authors...
Introduction Orthopaedic injuries affect almost 90% of trauma patients. A previous scoping review and expert consultation survey identified 15 potential low-value intra-hospital practices in the adult orthopaedic trauma population. Limiting the frequency of such practices could reduce adverse events, improve clinical outcomes and free up resources. The aim of this study is to synthesise the evidence on intra-hospital practices for orthopaedic injuries, previously identified as potentially of low...
#1Anneka Elizabeth Welford (University of Birmingham)
#2Susan A. Lanham-New (University of Surrey)H-Index: 22
Last. Carolyn A Greig (Arthritis Research UK)
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Introduction Sarcopenia is a progressive loss in muscle mass, strength and function, the adverse consequences of which are severe, affecting quality of life and placing an increasing burden on social and healthcare systems. Vitamin D status is known to be associated with markers of sarcopenia, namely muscle mass, strength and function. Also, resistance exercise training (RET) is currently the only proven intervention to treat sarcopenia. However, very little data exist on the influence of combin...
#1Anthony Kong (University of Birmingham)H-Index: 16
#2James S. Good (University Hospitals Birmingham NHS Foundation Trust)H-Index: 1
Last. S. Schipani (Beatson West of Scotland Cancer Centre)H-Index: 1
view all 16 authors...
Introduction Patients with head and neck squamous cell carcinoma with locally advanced disease often require multimodality treatment with surgery, radiotherapy and/or chemotherapy. Adjuvant radiotherapy with concurrent chemotherapy is offered to patients with high-risk pathological features postsurgery. While cure rates are improved, overall survival remains suboptimal and treatment has a significant negative impact on quality of life. Cell cycle checkpoint kinase inhibition is a promising metho...
#1Kieran Shah (UBC: University of British Columbia)H-Index: 3
#2Gregory Egan (Vancouver General Hospital)H-Index: 2
Last. Aaron M Tejani (UBC: University of British Columbia)H-Index: 11
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Background Discrepancies in outcome reporting (DOR) between protocol and published studies include inclusions of new outcomes, omission of prespecified outcomes, upgrade and downgrade of secondary and primary outcomes, and changes in definitions of prespecified outcomes. DOR can result in outcome reporting bias (ORB) when changes in outcomes occur after knowledge of results. This has potential to overestimate treatment effects and underestimate harms. This can also occur at the level of systemat...
#1Lindsay A. Jibb (U of T: University of Toronto)H-Index: 11
#2Paul C. NathanH-Index: 36
Last. Caron Strahlendorf (UBC: University of British Columbia)H-Index: 7
view all 21 authors...
Introduction Pain negatively affects the health-related quality of life (HRQL) of adolescents with cancer. The Pain Squad+ smartphone-based application (app), has been developed to provide adolescents with real-time pain self-management support. The app uses a validated pain assessment and personalised pain treatment advice with centralised decision support via a registered nurse to enable real-time pain treatment in all settings. The algorithm informing pain treatment advice is evidence-based a...
#1Rosalind AdamH-Index: 5
#2Saravanakumar Kanakarajan (ARI: Aberdeen Royal Infirmary)H-Index: 1
Last. Helen F. Galley (Aberd.: University of Aberdeen)H-Index: 30
view all 5 authors...
Introduction Chronic pain is prevalent, and approximately half of patients with chronic pain experience sleep disturbance. Exogenous melatonin is licensed to treat primary insomnia and there is some evidence for analgesic effects of melatonin. The aim of this study is to investigate the effects of oral melatonin (as Circadin) 2 mg at night in adults with severe non-malignant pain of at least 3 months’ duration. Methods and analysis We will conduct a randomised double-blind placebo-controlled cro...
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