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#1Michael J. MorrisH-Index: 15
#2Robert J. WalterH-Index: 10
Last.Aaron B. Holley (Walter Reed National Military Medical Center)H-Index: 15
view all 8 authors...
Abstract Background Chronic respiratory symptoms are frequently reported after southwest Asia deployment in support of combat operations. The full spectrum of clinical lung diseases related to these deployments is not well characterized. Methods Military personnel with chronic symptoms, primarily exertional dyspnea, underwent a standardized cardiopulmonary evaluation at two tertiary medical centers. Pulmonary function testing consisted of spirometry, lung volumes, diffusing capacity, impulse osc...
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#1Yuka Okajima (Brigham and Women's Hospital)H-Index: 13
#2Carolyn E. Come (Brigham and Women's Hospital)H-Index: 11
Last.Seth Kligerman (UCSD: University of California, San Diego)H-Index: 15
view all 17 authors...
Abstract Background Mucous exudates occluding the lumen of small airways are associated with reduced lung function and mortality in COPD subjects; however, luminal plugs in large airways have not been widely studied. We aimed to examine the associations of chest computed tomography (CT)-identified luminal plugging with lung function, health-related quality of life, and COPD phenotypes. Methods We randomly selected 100 smokers without COPD and 400 with COPD from the COPDGene Study. Luminal pluggi...
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#1Yunuen Aguilera Garcia (SU: Syracuse University)H-Index: 1
#2Atul Palkar (Norwich University)H-Index: 4
Last.Paul H. MayoH-Index: 23
view all 5 authors...
Abstract Purpose This prospective observational study reports on diaphragm excursion, velocity of diaphragm contraction, and changes in pleural pressure that occur with thoracentesis. Methods Twenty-eight patients with pleural effusion underwent therapeutic thoracentesis. Diaphragm excursion and velocity of diaphragm contraction were measured with M-mode ultrasonography of the affected hemidiaphragm. Pleural pressure was measured at each aliquot of 250cc of fluid removal. Fluid removal was conti...
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#1Kevin Davidson (MCV: VCU Medical Center)H-Index: 1
#2Kevin Davidson (MCV: VCU Medical Center)
Last.Samira Shojaee (MCV: VCU Medical Center)H-Index: 2
view all 2 authors...
Massive hemoptysis is a medical emergency with high mortality presenting several difficult diagnostic and therapeutic challenges. The origin of bleeding and underlying etiology often is not immediately apparent, and techniques for management of this dangerous condition necessitate an expedient response. Unlike hemorrhage in other circumstances, a small amount of blood can rapidly flood the airways, thereby impairing oxygenation and ventilation, leading to asphyxia and consequent cardiovascular c...
1 CitationsSource
#1David M. Mannino (UK: University of Kentucky)H-Index: 79
#2Byron Thomashow (CUMC: Columbia University Medical Center)H-Index: 23
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#1Catherine E. Simpson (Johns Hopkins University)H-Index: 2
#2Rachel L Damico (Johns Hopkins University)H-Index: 18
Last.Eric D. Austin (Vandy: Vanderbilt University)H-Index: 31
view all 13 authors...
Abstract Background Three biomarkers, soluble suppression of tumorigenicity 2 (ST2), galectin 3 (Gal3), and the N-terminal brain natriuretic peptide prohormone (NT-proBNP) are approved for noninvasive risk assessment in left heart failure, and small observational studies have shown their prognostic utility in heterogeneous pulmonary hypertension cohorts. We examined associations between these biomarkers and disease severity and survival in a large cohort of patients with Group I pulmonary arteri...
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#2Takayoshi Morita (Osaka University)H-Index: 3
Last.Hiroyuki YamaneH-Index: 14
view all 7 authors...
Case Presentation A 78-year-old man with asthma and COPD presented with shortness of breath, cough, and severe malaise for 4 days. Upon arrival, the patient was conscious and body temperature was 37.5°C. Arterial oxygen saturation (Spo2) was 80% on room air. Laboratory data demonstrated a WBC count of 17,400/μL (89.5% neutrophils) and C-reactive protein of 5.00 mg/dL. CT scan of chest revealed scattered ground-glass in the upper right lobe and thickening of the bronchial wall. Based on these fin...
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#1Gerard A. Silvestri (MUSC: Medical University of South Carolina)H-Index: 50
#2Benjamin Bevill (MUSC: Medical University of South Carolina)H-Index: 1
Last.Nichole T. Tanner (MUSC: Medical University of South Carolina)H-Index: 16
view all 13 authors...
Abstract Introduction Bronchoscopy is commonly used to evaluate suspicious lung lesions. The yield is likely dependent on patient, radiographic and bronchoscopic factors. Few studies have assessed these factors simultaneously while also including the pre-procedure physician assessed probability of cancer (pCA) when assessing yield. Methods This is a secondary data analysis from a prospective multicenter trial. Diagnostic yield of standard bronchoscopy with biopsy +/- fluoroscopy (Bronch-BX), end...
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#1Jennifer S. Hanberg (Yale University)H-Index: 9
#2Dana W. Dunne (Yale University)H-Index: 7
Case Presentation The patient is a 37-year-old hospital employee and current smoker with a 10 pack-year smoking history, who presented with dyspnea, chest pain, and weight loss. She was in her usual state of health until 4 months prior to admission when she developed intermittent left-sided chest pain, cough productive of scant yellow sputum, fevers, and anorexia. Initial chest radiograph was normal and her outpatient physician prescribed azithromycin, which she took without improvement. One mon...
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#1Luigi Taranto-Montemurro (Brigham and Women's Hospital)H-Index: 14
#2Ludovico Messineo (University of Brescia)H-Index: 6
Last.Scott A. Sands (Brigham and Women's Hospital)H-Index: 33
view all 9 authors...
Abstract Background We recently showed that the administration of the combination of the noradrenergic drug atomoxetine plus the antimuscarinic oxybutynin (ato-oxy) before sleep greatly reduced obstructive sleep apnea (OSA) severity, likely by increasing upper airway dilator muscle activity during sleep. Research question In patients with OSA who performed the ato-oxy trial with an esophageal pressure catheter to estimate ventilatory drive, we measured the effect of the drug combination (n=17) a...
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