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#1Sophie G. Carter (UNSW: University of New South Wales)H-Index: 2
#2Jayne C. Carberry (UNSW: University of New South Wales)H-Index: 7
Last. Danny J. Eckert (UNSW: University of New South Wales)H-Index: 34
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Abstract Background Recent studies indicate that standard doses of hypnotics reduce or do not change the apnea-hypopnea index (AHI) or pharyngeal muscle activity. A 1-month trial of nightly zopiclone (7.5mg) modestly reduced the AHI versus baseline without changing other sleep parameters or next-day sleepiness. Research question This study aimed to determine the effects of high-dose zopiclone (15mg) on AHI, arousal threshold, genioglossus muscle responsiveness and next-day alertness in selected ...
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#1Boris Shkolnik (Albany Medical College)
#2Marc A. Judson (Albany Medical College)H-Index: 47
Last. Amit Chopra (Albany Medical College)H-Index: 7
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Abstract Background There are limited data examining the diagnostic accuracy of thoracic ultrasonography (TUS) in distinguishing transudative from exudative pleural effusions. Research Question What is the diagnostic accuracy of TUS in distinguishing transudative from exudative effusions in consecutive patients with pleural effusion? Study Design and Methods Consecutive patients who underwent TUS and subsequently a diagnostic thoracentesis with a pleural fluid analysis were identified. TUS image...
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#1Michelle N. Eakin (Johns Hopkins University)H-Index: 19
#2Thomas Eckmann (Johns Hopkins University)H-Index: 3
Last. Dale M. NeedhamH-Index: 61
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Abstract Background Participant retention is a major challenge in clinical research, especially in studies with multiple, longitudinal research assessments Despite the importance of retention methods, there is little empirical research on how cohort retention efforts are perceived by study participants. Research Question To evaluate the association between the number of attempts undertaken to contact participants for research assessments in a longitudinal cohort study and participants' feeling o...
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#1Jose Iglesias (Community Medical Center)
#2Andrew Vassallo (Community Medical Center)
Last. Yasmine Elbaga (Monmouth Medical Center)
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Abstract Background Sepsis is a major public health burden resulting in 25-30% in-hospital mortality and accounting for over 20 billion dollars of United States hospital costs. Methods This was a randomized, double-blinded, placebo controlled trial conducted from February 2018 to June 2019 assessing an ascorbic acid (AA), thiamine, and hydrocortisone (HAT) treatment bundle for the management of septic and septic shock patients admitted to an intensive care unit (ICU). The primary outcomes were r...
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#1Mai Wang (VUMC: Vanderbilt University Medical Center)
#2Emily Pei-Ying LinH-Index: 1
Last. Chao-Han Lai (VUMC: Vanderbilt University Medical Center)H-Index: 1
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Abstract Background Acute exacerbation (AE) of chronic obstructive pulmonary disease (COPD) may be accompanied by the deterioration of cardiovascular comorbidities, as evidenced by the increased incidence of acute cardiovascular events. Research Question Whether preceding AE might be associated with mortality of cardiovascular events remains unknown. Study Design and Methods Using a health insurance research database in Taiwan, we identified patients with COPD who experienced first-time acute my...
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#1Aparna Balasubramanian (Johns Hopkins University)
#2Todd Matthew Kolb (Johns Hopkins University)H-Index: 12
Last. Stephen C. Mathai (Johns Hopkins University)H-Index: 29
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Abstract Background Patients with chronic obstructive pulmonary disease (COPD) who develop pulmonary hypertension (PH) have worse mortality than those with COPD alone. Predictors of poor outcomes in COPD-PH are not well described. Diffusing capacity of the lung (DLCO) assesses the integrity of the alveolar-capillary interface and thus may be a useful prognostic tool among those with COPD-PH. Research Question Using a single center registry, we sought to evaluate DLCO as a predictor of mortality ...
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#1Patrícia Rebelo (University of Aveiro)H-Index: 2
Last. Alda Marques (University of Aveiro)H-Index: 16
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Abstract Background Fatigue is a burdensome and prevailing symptom in patients with chronic obstructive pulmonary disease (COPD). Pulmonary rehabilitation (PR) improves fatigue however, interpreting when such improvement is clinically relevant is challenging. Minimal clinically important differences (MCIDs) for instruments assessing fatigue are warranted to better tailor PR and guide clinical decisions. We estimated MCIDs for the functional assessment of chronic illness therapy-fatigue subscale ...
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#1Tuang Yeow Poh (NTU: Nanyang Technological University)H-Index: 1
#2Pei Yee Tiew (NTU: Nanyang Technological University)H-Index: 3
Last. Adrian Chan (SGH: Singapore General Hospital)H-Index: 5
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Abstract Background and Research Question: Chitinase activity is an important innate immune defence mechanism against infection including fungi. The two human chitinases: chitotriosidase (CHIT1) and acidic mammalian chitinase (AMCase) are associated to allergy, asthma and chronic obstructive pulmonary disease (COPD), however, their role in bronchiectasis and bronchiectasis-COPD overlap (BCO) is unknown Study Design and Methods A prospective cohort of n=463 individuals were recruited across five ...
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#1J.V. Pugashetti (UC Davis: University of California, Davis)H-Index: 1
#2Aleksander Kitich (UCLA: University of California, Los Angeles)
Last. Elena Foster (UC Davis: University of California, Davis)H-Index: 5
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Abstract Background Interstitial lung disease (ILD) results in high morbidity and healthcare utilization. Diagnostic delays remain common and often occur in non-pulmonology settings. Screening for ILD in these settings has the potential to reduce diagnostic delays and improve patient outcomes. Research Question Can a pulmonary function test (PFT)-derived diagnostic prediction tool (ILD-Screen) accurately identify incident ILD cases in patients undergoing PFT in non-pulmonology settings. Study De...
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#1Anne B. Chang (Boston Children's Hospital)H-Index: 57
#2John J. Oppenheimer (RU: Rutgers University)H-Index: 12
Last. Richard S. Irwin (UMass Memorial Health Care)H-Index: 56
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Abstract Background Cough is one of the most common presenting symptoms to general practitioners. The objective of this article is to collate the pediatric components of the CHEST chronic cough guidelines that have recently updated the 2006 guidelines to assist general and specialist medical practitioners in the evaluation and management of children who present with chronic cough. Methods We reviewed all current CHEST Expert Cough Panel's statements and extracted recommendations and suggestions ...
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