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#1Shaowa Lü (Heilongjiang University of Chinese Medicine)H-Index: 6
#2Yutian Liu (Heilongjiang University of Chinese Medicine)
Last.Qiuhong Wang (Guangdong Pharmaceutical University)H-Index: 5
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Abstract Background Caulophyllum robustum Maxim (CRM) is a medicinal compound of the Northeast and is commonly used in China for the treatment of rheumatic pain and rheumatoid arthritis (RA). A preliminary study found that CRM has good anti-inflammatory, analgesic and immunosuppressive effects. However, the specific links and targets for its function remain unclear. Our study aimed to provide a mechanism for the action of Caulophyllum robustum Maxim extraction (CRME) against RA and to establish ...
#1Camilla De Lima (UFPE: Federal University of Pernambuco)
#2Eliezer RushanskyH-Index: 2
Last.Paula Sandrin-Garcia (UFPE: Federal University of Pernambuco)H-Index: 9
view all 9 authors...
Abstract This study evaluated the possible association between SNPs in cytokines coding genes, namely IL10, IL6 and IFNG, cytokines serum levels and clinical assessment' scores in patients with Rheumatoid Arthritis(RA). SNPs genotyping was performed in 126 RA patients and 177 healthy individuals with Taqman probes specific for IL10 -1082 (T>C, rs1800896);INFG -1616 (A>G, rs2069705) and IL6 -174 (G>C, rs1800795) variants,positioned in regulatory regions. Cytokine Bead Array (CBA) was used to meas...
#1Jia Li (PolyU: Hong Kong Polytechnic University)H-Index: 3
#2Ding Long (HUST: Huazhong University of Science and Technology)H-Index: 3
Last.Xiangyan Chen (PolyU: Hong Kong Polytechnic University)
view all 11 authors...
Abstract Complement factor H (CFH) serves as a major down-regulator in the complement system, often utilized by bacterial pathogens to evade complement attack. Yet, little is currently known about the genetic correlation of CFH polymorphisms with sepsis due to various microbial infections. A case-control method (488 septic patients and 527 healthy individuals) was carried out in this study to investigate the genetic relationship between CFH polymorphisms (rs3753394 C/T, rs1065489 G/T and rs10611...
#1Hui Hui (MOE: Chinese Ministry of Education)H-Index: 2
#2Hao Yang (MOE: Chinese Ministry of Education)H-Index: 1
Last.Na Lu (MOE: Chinese Ministry of Education)H-Index: 6
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#1Hong Wang (Fudan University)H-Index: 5
#2Bei Xu (Fudan University)
Last.Jun Shi (SJTU: Shanghai Jiao Tong University)
view all 3 authors...
Abstract N6-methyladenosine (m6A) is the most prevalent internal modification in mammalian mRNAs and methyltransferase-like 3 (METTL3) is a vital methyltransferase in m6A modification. Here, this study tries to discover the regulatory role of METTL3 and its mechanism in the breast cancer tumorigenesis. Results found that METTL3 was up-regulated in the breast cancer tissue and cells. In vivo and vitro, METTL3 knockdown could decrease the methylation level, reduce the proliferation, accelerate the...
#1Leila Mobasheri (Birjand University of Medical Sciences)
#2Seyedeh Zahra Moossavi (Shiraz University of Medical Sciences)
Last.Gholamreza Anani Sarab (Birjand University of Medical Sciences)H-Index: 2
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Abstract Background and aim Autism spectrum disorder (ASD) is one of the neurodevelopmental and cognitive conditions that involves 1 in 160 children around the world. Several studies showed that there is a relationship between vitamin D receptor (VDR) gene polymorphisms with the neurodevelopmental behavioral disorders. In the current study, we aimed to highlight the association of VDR gene polymorphisms (FokI and TaqI) with the risk of autism in Birjand population. Material and methods In this c...
#1Xuefeng Wei (Xinyang Normal University)
#2Shuang Han (Xinyang Normal University)
Last.Yun Ma (Ningxia University)H-Index: 1
view all 9 authors...
#1Tao Sun (JLU: Jilin University)
#2Yang Liu (JLU: Jilin University)H-Index: 6
Last.Fuzhe Ma (JLU: Jilin University)H-Index: 1
view all 4 authors...
Abstract Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Accumulating evidence shows that microRNAs play important roles in diabetic kidney. However, the potential role of MicroRNA-544 (miR-544) in DN remains unclear. In this study, we explored the role of miR-544 on inflammation and fibrosis in diabetic kidney using db/db mice. Renal expression of miR-544 was decreased in mice, companied by increased the expression of FASN. The dual luciferase assay confirmed FASN as ...
#1Chintalapati Janaki (IISc: Indian Institute of Science)
#2Manoharan Malini (IISc: Indian Institute of Science)
Last.Narayanaswamy Srinivasan (IISc: Indian Institute of Science)H-Index: 39
view all 0 authors...
Abstract Viral kinases are known to undergo autophosphorylation and also phosphorylate viral and host substrates. Viral kinases have been implicated in various diseases and are also known to acquire host kinases for mimicking cellular functions and exhibit virulence. Although substantial analyses have been reported in the literature on diversity of viral kinases, there is a gap in the understanding of sequence and structural similarity among kinases from different classes of viruses. In this stu...
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