Papers 1959
1 page of 196 pages (1,959 results)
#1Zhihong Wang (Qingdao University)
#2Min Zhang (Qingdao University)
Last. Qun Chen (National Health and Family Planning Commission)
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Endothelial cell (EC) dysfunction is a major symptom associated with the initiation of atherosclerosis (AS). Cyanidin-3-O-glucoside (C3G) has the potentials to attenuate AS symptoms. In the current study, the mechanism driving the effects of C3G on AS rabbits and injured ECs were explored by focusing on the changes in miR-204-5p/SIRT1 axis. AS symptoms were induced in rabbits using high-fatty diet (HFD) plus balloon catheter injured method and handled with C3G of two doses. Then the changes in a...
#1Qingya Hao (Soochow University (Suzhou))
#2Lihua Gao (Nantong University)
Last. Zhong Chen (Soochow University (Suzhou))
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To explore the role of POTEE in the malignant development of pancreatic cancer and the possible mechanism. POTEE levels in pancreatic cancer samples were detected. The relationship between POTEE level and clinical data of pancreatic cancer patients was analyzed. After knockdown of POTEE or treatment of the GSK-3β inhibitor, proliferative change in pancreatic cancer cells was assessed. Protein levels of vital genes in the PI3K/Akt/GSK-3β/β-catenin signaling influenced by POTEE were examined. POTE...
BACKGROUND Both circular RNA DOCK1 (circDOCK1) and microRNA-124 (miR-124) are implicated in carcinogenesis, but functional association between these two molecules remains uncharacterized. Here, we aimed to ascertain the role of circDOCK1-miR-124 node in thyroid cancer cells. METHODS circDOCK1 in thyroid cancer specimens from 25 patients was quantified by qRT-PCR. FTC-133 and TPC-1 cells were enforced to overproduce circDOCK1 and miR-124 which were confirmed by qRT-PCR. The alteration in viabilit...
Rheumatoid arthritis (RA) is a common chronic autoimmune disease in women. This research aims to disclose the probable function of lncRNA H19 in MH7A cells. The influences of tumor necrosis factor-α (TNF-α) on cell viability, apoptosis, and inflammatory factor expression were, respectively, detected through cell counting kit-8 (CCK-8), flow cytometry, quantitative reverse transcription polymerase chain reaction (qRT-PCR), enzyme-linked immunosorbent assay (ELISA) assay and Western Blot. The leve...
#1Roberta Ricciarelli (UniGe: University of Genoa)H-Index: 26
#2Angelo Azzi (Tufts University)H-Index: 64
Last. Jean-Marc Zingg (UM: University of Miami)H-Index: 3
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Cell senescence is due to the permanent cell cycle arrest that occurs as a result of the inherent limited replicative capacity toward the Hayflick limit (replicative senescence), or in response to various stressors (stress-induced premature senescence, SIPS). With the acquisition of the senescence-associated secretory phenotype (SASP), cells release several molecules (cytokines, proteases, lipids), and express the senescence-associated beta-galactosidase (SA-β-Gal). Here we tested whether vitami...
#1Sasivimon Promsan (CMU: Chiang Mai University)H-Index: 2
#2Anusorn Lungkaphin (CMU: Chiang Mai University)H-Index: 12
: Obesity is a common and complex health problem worldwide and can induce the development of Type 2 diabetes. Chronic kidney disease (CKD) is a complication occurring as a result of obesity and diabetic conditions that lead to an increased mortality rate. There are several mechanisms and pathways contributing to kidney injury in obese and diabetic conditions. The expansion of adipocytes triggers proinflammatory cytokines release into blood circulation and bind with the receptors at the cell memb...
#1Fangxian Liu (GLMU: Guilin Medical University)
#2Qijin Pan (Guangxi Medical University)
Last. Wenjun Huang (GLMU: Guilin Medical University)
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: Calycosin is a naturally occurring phytoestrogen, and it has the anti-nasopharyngeal carcinoma (NPC) action played by calycosin. However, the elaborate mechanisms of calycosin treating NPC remain to be unrevealed. In current report, a promising tool of network pharmacology method was used to uncover the anti-NPC targets and therapeutic mechanisms played by calycosin. Furthermore, were conducted to validate the bioinformatic findings in human and preclinical studies. As results, the bioinformat...
#1Solmaz Mohammadi (Tabriz University of Medical Sciences)H-Index: 1
Last. Mehdi Yousefi (Tabriz University of Medical Sciences)H-Index: 24
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: As an evolutionarily conserved pathway, Hippo signaling pathway impacts different pathology and physiology processes such as wound healing, tissue repair/size and regeneration. When some components of Hippo signaling dysregulated, it affects cancer cells proliferation. Moreover, the relation Hippo pathway with other signaling including Wnt, TGFβ, Notch, and EGFR signaling leaves effect on the proliferation of cancer cells. Utilizing a number of therapeutic approaches, such as siRNAs and long n...
#1Seyyedeh Mina Hejazian (Tabriz University of Medical Sciences)
#2Yalda Rahbar Saadat (Tabriz University of Medical Sciences)H-Index: 6
Last. Sepideh Zununi Vahed (Tabriz University of Medical Sciences)H-Index: 12
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: Podocytes play an essential role in the regulation of glomerular filtration and the appropriate function of the kidney. Podocytes injury is involved in the pathogenesis of nephrotic syndrome (NS), a common renal glomerulus dysfunction characterized by proteinuria. Some in vivo studies in Dicer/Drosha knockout mice indicate the importance of Dicer, Drosha, and microRNAs (miRNAs) in the pathogenesis of NS. In the present study, the expression levels of Dicer and Drosha along with miR-30 family, ...
#1Perinur Bozaykut (Marmara University)H-Index: 1
Last. Nesrin Kartal Ozer (Marmara University)H-Index: 24
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Formation of atherosclerotic plaques, called atherogenesis, is a complex process affected by genetic and environmental factors. It was proposed that endoplasmic reticulum (ER) stress is an important factor in the pathogenesis of atherosclerosis and that vitamin E affects atherosclerotic plaque formation via its antioxidant properties. Here, we investigated ER stress-related molecular mechanisms in high-cholesterol diet (HCD, 2%)-induced atherosclerosis model and the role of vitamin E supplementa...
Top fields of study
Diabetes mellitus