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Journal of Proteome Research
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#1Libia SanzH-Index: 47
Last. Alfonso ZavaletaH-Index: 8
view all 17 authors...
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#1Wei Xu (WUR: Wageningen University and Research Centre)H-Index: 2
#2Ariette T.M. van Knegsel (WUR: Wageningen University and Research Centre)H-Index: 5
Last. Jacques Vervoort (WUR: Wageningen University and Research Centre)H-Index: 53
view all 6 authors...
Dairy cows can experience a negative energy balance (NEB) in early lactation when feed intake is too low to meet energy requirements for body maintenance and milk production. Metabolic changes occur in mammary gland cells of animals experiencing a negative energy balance. We studied these metabolic changes in milk samples from diary cows in relation to energy balance status using liquid chromatography mass spectrometry (QQQ-LC-MS) and nuclear magnetic resonance (1H-NMR). NMR and LC-MS techniques...
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#1Qingqing Wang (CAS: Chinese Academy of Sciences)H-Index: 1
#2Benzhe Su (DUT: Dalian University of Technology)H-Index: 2
Last. Guowang Xu (DICP: Dalian Institute of Chemical Physics)H-Index: 61
view all 9 authors...
Assessment and prediction of prognostic risk in patients with hepatocellular carcinoma (HCC) would greatly benefit the optimal treatment selection. Here, we aimed to identify the critical metabolites associated with the outcomes and develop a risk score to assess the prognosis of HCC patients after curative resection. A total of 78 serum samples of HCC patients were analyzed by liquid chromatography-mass spectrometry (LC-MS) to characterize the metabolic profiling. A novel network-based feature ...
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Enteroviruses (EVs) are major causes of viral meningoencephalitis in children. To better understand the pathogenesis and identify potential biomarkers, cerebrospinal fluid proteome in children (n = 52) suffering from EV-meningoencephalitis was compared to that in EV-negative control subjects (n = 53) using the BoxCar acquisition technique. Among 1697 proteins identified, 1193 with robust assay readouts were used for quantitative analyses. Differential expression analyses identified 154 upregulat...
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#1Jakub NovakH-Index: 2
#2Ivo FabrikH-Index: 12
Last. Peter SeboH-Index: 40
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Post-translational modifications of proteins enable swift physiological adaptation of cells to altered growth conditions and stress. Aside from protein phosphorylation, acetylation on e-amino groups of lysine residues (N-e-lysine acetylation) represents another important post-translational modification of proteins. For many bacterial pathogens, including the whooping cough agent Bordetella pertussis, the role and extent of protein acetylation remains to be defined. We expressed in E. coli the BP...
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#1Tomohiro Kohata (Kumamoto University)H-Index: 2
#2Shingo Ito (Kumamoto University)H-Index: 8
Last. Sumio Ohtsuki (Kumamoto University)H-Index: 55
view all 6 authors...
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. The purpose of the present study was to identify GBM cell-selective secreted proteins by analyzing conditioned media (CM) from GBM, breast, and colon cancer cell lines using sequential window acquisition of all theoretical spectra-mass spectrometry (SWATH-MS) and targeted proteomics. We identified 2371 proteins in the CM from GBM and the other cancer cell lines. Among the proteins identified, 15 showed significantly high...
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Hepatic Encephalopathy (HE) is a debilitating neuropsychiatric complication associated with acute and chronic liver failure. It is characterized by diverse symptoms with variable severity that includes cognitive and motor deficits. The aim of the study is to assess metabolic alterations in brain and liver using nuclear magnetic resonance (NMR) spectroscopy and subsequent multivariate analyses to characterize metabolic signatures associated with HE. HE was developed by bile duct ligation (BDL) th...
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#1Helena Kenny (DCU: Dublin City University)H-Index: 5
#2Georg TascherH-Index: 4
Last. Stéphane Blanc (UDS: University of Strasbourg)H-Index: 25
view all 12 authors...
Muscle atrophy is a deleterious consequence of physical inactivity and is associated with increased morbidity and mortality. The aim of this study was to decipher the mechanisms involved in disuse muscle atrophy in 8 healthy men using 21-day bed rest with a cross-over design (control, with resistive vibration exercise (RVE) or RVE combined with whey protein supplementation and an alkaline salt (NEX)). The main physiological findings show a significant reduction in whole body fat free mass (CON -...
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#1Matthew E. MacGilvray (UW: University of Wisconsin-Madison)H-Index: 8
#2Evgenia Shishkova (UW: University of Wisconsin-Madison)H-Index: 6
Last. Audrey P. Gasch (UW: University of Wisconsin-Madison)H-Index: 38
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To cope with sudden changes in the external environment, the budding yeast Saccharomyces cerevisiae orchestrates a multi-faceted response that spans many levels of physiology. Several studies have interrogated the transcriptome response to endoplasmic reticulum (ER) stress and the role of regulators such as the Ire1 kinase and Hac1 transcription factor. However, less is known about responses to ER stress at other levels of physiology. Here, we used quantitative phosphoproteomics and computationa...
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