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Journal of Clinical Gastroenterology
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#2Ernest Belmonte (University of Barcelona)H-Index: 3
Last. Carmen Ayuso (University of Barcelona)H-Index: 48
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GOALS To describe the occurrence of malabsorption (MA) in hepatocellular carcinoma (HCC) patients under sorafenib, the potential relationship with pancreatic insufficiency (PI), and the role of pancreatic enzymes supplementation. BACKGROUND With the increasing options of second-line systemic therapies for HCC, the recognition of drug intolerance using practical tools is crucial. It has been proposed that a MA syndrome could be due to sorafenib-induced pancreatic dysfunction. STUDY All sorafenib-...
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In the current COVID-19 pandemic, there has been concern regarding the use of ibuprofen and other nonsteroidal anti-inflammatory agents by COVID-19 infected patients. Aminosalicylates (5-ASAs) are structurally similar and have anti-inflammatory functions that resemble those of nonsteroidal anti-inflammatory agents. Since 5-ASAs are a mainstay treatment for inflammatory bowel disease, the authors review the pharmacology of both classes of drugs and discuss the potential relevance of 5-ASAs in the...
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Last. Yuk Ting Ma (University Hospitals Birmingham NHS Foundation Trust)H-Index: 9
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BACKGROUND Recent studies have revealed that coadministration of gastric acid suppressants reduces the efficacy of the tyrosine kinase inhibitors erlotinib and sunitinib in patients with non-small cell lung cancer and renal cell carcinoma, respectively. The authors have therefore assessed if the concurrent use of gastric acid suppressants and sorafenib impairs outcomes in patients with advanced hepatocellular carcinoma (HCC). METHODS A retrospective analysis was conducted on all patients treated...
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#1Farah Shirazi (CPMC: California Pacific Medical Center)
#2Ashwani K. Singal (USD: University of South Dakota)H-Index: 19
Last. Robert J. Wong (Alameda Health System)H-Index: 17
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GOALS The goals of this study were to evaluate trends in hospitalizations and in-hospital mortality among US adults with alcohol-associated cirrhosis and alcoholic hepatitis. BACKGROUND Alcohol-associated liver disease contributes to significant liver-related morbidity in the United States, among which inpatient care is a major driver of clinical and economic burden. METHODS Using the 2007-2014 National Inpatient Sample, alcohol-associated cirrhosis and alcoholic hepatitis hospitalizations were ...
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#1Ofer Z. FassH-Index: 3
#2Kamrine Poels (Harvard University)
Last. Peter S. LiangH-Index: 7
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GOALS The goal of this study was to quantify the association between demographic factors and advanced colorectal cancer (CRC) in patients under age 50. BACKGROUND CRC incidence in the United States has declined in older individuals but increased in those under age 50 (early-onset). More than 60% of early-onset CRC patients present with advanced disease (stage III/IV), but predictors of stage in this population are poorly defined. STUDY We analyzed CRC cases diagnosed between age 20 and 49 in the...
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#1Einat AlmonH-Index: 4
#2Yoseph ShaaltielH-Index: 8
Last. Sari AlonH-Index: 4
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BACKGROUND AND OBJECTIVE OPRX-106 is an orally administered BY2 plant cell-expressing recombinant TNF fusion protein (TNFR). Oral administration of OPRX-106 was shown to be safe and effective in inducing favorable anti-inflammatory immune modulation in humans. The current study was aimed at determining the safety and efficacy of OPRX-106 in patients with ulcerative colitis (UC). METHODS Twenty-five patients with active mild-to-moderate UC were enrolled in an open-label trial. Patients were rando...
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#1Giuseppe Vanella (UniSR: Vita-Salute San Raffaele University)
#2Gabriele CapursoH-Index: 37
Last. Paolo Giorgio ArcidiaconoH-Index: 29
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Over the past 20 years, endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) has generated interest as a novel minimally invasive tool in the multimodal treatment of pancreatic malignant and premalignant lesions. However, although optimization of probes and settings has made EUS-RFA relatively safe, questions on the ideal positioning of this treatment in a multimodal strategy remain unanswered. This review will summarize the technical aspects of EUS-RFA and available clinical experienc...
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#1Bharati Kochar (Harvard University)H-Index: 6
#2Yue Jiang (UNC: University of North Carolina at Chapel Hill)
Last. Millie D. LongH-Index: 27
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BACKGROUND The epidemiology of meningitis is unknown in inflammatory bowel disease (IBD) patients. GOALS We aimed to determine the incidence of and risk factors for meningitis in IBD patients. STUDY We conducted a retrospective cohort and nested case-control study in the Quintiles IMS Legacy PharMetrics Adjudicated Claims Database from January 2001 to June 2016. We matched IBD patients to those without IBD on age, sex, enrollment, and region. Meningitis was defined as one code for meningitis ass...
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#1Michael Dolinger (ISMMS: Icahn School of Medicine at Mount Sinai)
#2Jungwhan J. Choi (ISMMS: Icahn School of Medicine at Mount Sinai)
Last. Marla Dubinsky (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 59
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GOAL The goal of this study was to explore the utility of small bowel ultrasound (SBUS) as a noninvasive tool to assess induction response to infliximab (IFX) in pediatric Crohn's disease (CD). BACKGROUND Inflammatory bowel disease management has shifted to a treat-to-target and tight control strategy utilizing noninvasive serum and fecal markers to monitor disease activity in response to therapy. Bowel wall changes as seen on cross-sectional imaging may be a more accurate marker of treatment su...
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#1Isabel A. Hujoel (Mayo Clinic)H-Index: 4
#2Claire L. Jansson-Knodell (IUPUI: Indiana University – Purdue University Indianapolis)
Last. Alberto Rubio-Tapia (Cleveland Clinic)
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GOAL: The goal of this study was to estimate the impact of verification bias on the diagnostic accuracy of immunoglobulin A tissue transglutaminase (IgA tTG) in detecting celiac disease as reported by an authoritative meta-analysis, the 2016 Comparative Effectiveness Review (CER). BACKGROUND: Verification bias is introduced to diagnostic accuracy studies when screening test results impact the decision to verify disease status. MATERIALS AND METHODS: We adjusted the sensitivity and specificity of...
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