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Journal of Physiology and Biochemistry
IF
2.52
Papers
1340
Papers 1340
1 page of 134 pages (1,340 results)
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#1Rita Nogueira-Ferreira (University of Porto)H-Index: 7
#2Rita Ferreira (University of Aveiro)H-Index: 30
Last.Daniel Moreira-Gonçalves (University of Porto)H-Index: 13
view all 8 authors...
Aerobic exercise training induces a unique cardioprotective phenotype, but it is becoming clear that it does not promote the same structural, functional, and molecular adaptations in both ventricles. In the present study, we aimed to better characterize and compare the molecular pathways involved in the exercise-induced remodeling of both ventricles. Female Sprague-Dawley rats were randomly assigned to control and exercise groups. Animals in the exercise group were submitted to low-intensity tre...
#1Cheng Zhang (DUT: Dalian University of Technology)H-Index: 1
#2Qiong Wu (DUT: Dalian University of Technology)H-Index: 4
Last.Jianing Zhang (DUT: Dalian University of Technology)H-Index: 8
view all 8 authors...
Caveolin-1 (Cav-1) is a critical structural protein of caveolae and plays an oncogene-like role by participating in abnormal protein glycosylation in hepatocellular carcinoma (HCC). However, the mechanism by which Cav-1 regulates glycosylation and glycosyltransferase expression has not been completely defined. Here, we show that Cav-1 promotes the expression of Rfng, which is a β-1,3-N-acetylglucosaminyltransferase included in the Fringe family. In this study, we showed that the mouse HCC cell l...
#1Wenjing Sun (Kunming Medical University)H-Index: 1
#2Hongquan Lu (Kunming Medical University)
Last.Di Lu (Kunming Medical University)H-Index: 6
view all 8 authors...
Inflammation is a pivotal feature of myocardial reperfusion–induced microvascular injury and dysfunction. However, the molecular mechanisms by which myocardial reperfusion triggered inflammation remain incurable. The NLRP3 inflammasome is a key intracellular sensor that detection of cellular stress to activation of caspase-1, and consequent IL-1β maturation and pyroptotic cell death. Here, we showed that NLRP3 inflammasome played a key role in myocardial reperfusion–induced microvascular injury....
#1Gema Mondejar-Parreño (Complutense University of Madrid)H-Index: 3
#2María Callejo (Complutense University of Madrid)H-Index: 4
Last.Francisco Perez-Vizcaino (Complutense University of Madrid)H-Index: 37
view all 9 authors...
Endothelial dysfunction plays a central role in the pathophysiology of pulmonary arterial hypertension (PAH). MicroRNAs (miRNAs) are small single-strand and non-coding RNAs that negatively regulate gene function by binding to the 3′-untranslated region (3′-UTR) of specific mRNAs. microRNA-1 (miR-1) is upregulated in plasma from idiopathic PAH patients and in lungs from an experimental model of PAH. However, the role of miRNA-1 on endothelial dysfunction is unknown. The aim of this study was to a...
#1Amirah Abdul Rahman (UiTM: Universiti Teknologi MARA)H-Index: 3
#2Norfilza Mohd Mokhtar (UKM: National University of Malaysia)H-Index: 11
Last.Wan Zurinah Wan Ngah (UKM: National University of Malaysia)H-Index: 22
view all 5 authors...
Gamma-tocotrienol (GTT) and hydroxychavicol (HC) exhibit anticancer activity in glioma cancer cells, where the combination of GTT + HC was shown to be more effective than single agent. The aim of this study was to determine the effect of GTT + HC by measuring the cell cycle progression, migration, invasion, and colony formation of glioma cancer cells and elucidating the changes in gene expression mitigated by GTT + HC that are critical to the chemoprevention of glioma cell lines 1321N1 (grade II...
#1Ping Han (HUST: Huazhong University of Science and Technology)H-Index: 8
#2Jingmei Liu (HUST: Huazhong University of Science and Technology)H-Index: 6
Last.Wei Yan (HUST: Huazhong University of Science and Technology)H-Index: 10
view all 6 authors...
Collective cell migration plays an important role in embryonic development, wound healing, and cancer metastasis. We aimed to investigate the expression, role, and mechanism of Netrin-1 in collective cell migration using a3D culture model. An immunohistochemical study showed that certain cells invaded surrounding tissue by collective migration and that Netrin-1 expression in these cells was increased, especially at the invasive front. In the 3D culture model, collective cell migration was clearl...
#1Jianlin Zhao (CQMU: Chongqing Medical University)
#2Wei Peng (CQMU: Chongqing Medical University)H-Index: 4
Last.Hongbo Qi (CQMU: Chongqing Medical University)H-Index: 12
view all 8 authors...
Preeclampsia (PE) is a hypertensive disease associated with increased endothelial cell dysfunction caused by systemic oxidative stress. Alpha-actinin-4 (ACTN4) is a member of the α-actinin family of actin crosslinking proteins that are upregulated in several types of cancer. However, its role in PE remains unclear. In this study, we found that ACTN4 was localized in placenta vascular endothelial cells (ECs), and its expression was downregulated in primary human umbilical vein endothelial cells (...
Hepatitis has become a major social, health, and economic problem worldwide. Herein, we tested the beneficial influence of baicalin, a flavonoid extracted from the roots of Scutellaria baicalensis, on human normal liver L-02 and THLE2 cell apoptosis and inflammatory reaction stimulated by lipopolysaccharide (LPS) and possible molecular mechanisms. L-02 and THLE2 cell viability and apoptosis after LPS and/or baicalin treatment were tested using CCK-8 assay and Annexin V-FITC/PI apoptosis kit, res...
#1Charlotte Giraud (INRA: Institut national de la recherche agronomique)H-Index: 2
#2Anne Tournadre (INRA: Institut national de la recherche agronomique)H-Index: 21
Last.Frédéric Capel (INRA: Institut national de la recherche agronomique)H-Index: 13
view all 9 authors...
The increased cardiovascular risk in RA (rheumatoid arthritis) cannot be explained by common quantitative circulating lipid parameters. The objective of the study was to characterize the modifications in HDL phosphosphingolipidome in patients with RA to identify qualitative modifications which could better predict the risk for CVD. Nineteen patients with RA were compared to control subjects paired for age, sex, BMI, and criteria of metabolic syndrome. The characterization of total HDL phosphosph...
#1Jun Zhang (Southern Medical University)H-Index: 5
#2Tingting Jiang (Southern Medical University)H-Index: 1
Last.Xun Tang (Southern Medical University)H-Index: 4
view all 10 authors...
Epithelial-to-mesenchymal transition (EMT) and injury of tubular cells play critical roles in the pathogenesis of diabetic nephropathy (DN). lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) has been shown to be involved in DN progression. However, whether MALAT1 induces EMT and injury in tubular cells is unclear. Here, we investigated the effects of MALAT1 on human proximal tubular cells (HK-2 cells) and the underlying mechanism. We performed qPCR to detect MALAT1, E-cadher...
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