Journal of Physiology and Biochemistry
Papers 1164
1 page of 117 pages (1,164 results)
#1Thinhinane Hocine (URCA: University of Reims Champagne-Ardenne)H-Index: 2
#2Sébastien Blaise (URCA: University of Reims Champagne-Ardenne)H-Index: 9
Last. Béatrice Romier-Crouzet (URCA: University of Reims Champagne-Ardenne)H-Index: 3
view all 11 authors...
Elastin, the major protein of the extracellular matrix, is specially found in cardiovascular tissues and contributing to 30-50% of the dry weight of blood vessels. Elastin regulates cell signalling pathways involved in morphogenesis, injury response and inflammation. The function of elastin is frequently compromised in damaged or aged elastic tissues. Indeed, elastin degradation, observed during ageing, and the resulting production of elastin-derived peptides (EDPs), have crucial impacts on card...
Increased evidence indicates that adenosine monophosphate-activated protein kinase (AMPK) plays a vital role in vascular homeostasis, especially under hypoxia, and protects against the progression of pulmonary hypertension (PH). However, the role of AMPK in the pathogenesis of PH remains to be clarified. In the present study, we confirmed that a loss of AMPKα2 exacerbated the development of PH by using hypoxia-induced PH model in AMPKα2 -/- mice. After a 4-week period of hypoxic exposure, AMPKα2...
#1Valéria S. Nunes (USP: University of São Paulo)H-Index: 17
#2Patrícia M. Cazita (USP: University of São Paulo)H-Index: 9
Last. Eder C.R. Quintão (USP: University of São Paulo)H-Index: 25
view all 5 authors...
Monogenic familial hypercholesterolemia is characterized by impaired cellular uptake of apolipoprotein B containing lipoproteins. However, its consequences on whole-body cholesterol metabolism are unclear. We investigated cholesterol metabolism in wild-type mice (control) and in knockout (KO) mice for the low-density lipoprotein receptor (LDLR-KO) and for apolipoprotein E (apoE-KO) containing the genetic basis of the C57BL/6J mice, under a cholesterol-free diet. Cholesterol and "non-cholesterol"...
#1Asier Leniz (UPV/EHU: University of the Basque Country)H-Index: 1
#2Alfredo Fernández-Quintela (UPV/EHU: University of the Basque Country)H-Index: 21
Last. María P. Portillo (UPV/EHU: University of the Basque Country)H-Index: 34
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Infants born small for gestational age (SGA) are known to have increased risk of developing several pathologies, including the metabolic syndrome, when they grow up. It has been described that both the growth pattern of these children as well as the risk of their presenting future metabolic disorders can be influenced by the expression of adipokines. Among them, chemerin has demonstrated to be implicated in lipid and glucose metabolism, presenting higher circulating concentration in diabetic and...
#1Yongsheng Chen (PRC: China Medical University (PRC))H-Index: 2
#2Shuodong Wu (PRC: China Medical University (PRC))H-Index: 10
Last. Jing Kong (PRC: China Medical University (PRC))H-Index: 9
view all 6 authors...
Dysfunction of the Na+/H+ exchanger 3 (NHE3) contributes to the formation of cholesterol gallstones. We aimed to investigate whether NHE3 dysfunction is associated with abnormalities in NHE3 complex formation. We fed C57BL/6 mice with control or lithogenic diet and study the expression of NHE3, ezrin, and Na+/H+ exchanger regulatory factor 1 (NHERF1) in the gallbladder (GB) using RT-PCR and western blot. Immunofluorescence and immunoprecipitation were performed to investigate the interactions of...
#1Heba A. Abdel-Hamid (Minia University)H-Index: 2
#2Elshymaa A. Abdel-Hakeem (Minia University)
Last. Nisreen D. M. Toni (Minia University)H-Index: 2
view all 4 authors...
C-peptide is gaining much interest recently due to its well-documented beneficial effects on multiple organ dysfunction induced by diabetes. Our study was designed to investigate the effect of C-peptide on hepatocellular dysfunction in diabetic rats. Wistar male rats were separated into four groups: control, diabetic, diabetic + insulin, and diabetic + C-peptide. Serum levels of glucose, insulin, and liver biomarkers were assessed. Liver sections were collected for histopathological examination ...
Diabetes mellitus is a chronic metabolic disease characterized by high blood glucose concentration. Nowadays, type 2 diabetes or insulin resistant diabetes is the most common diabetes, mainly due to unhealthy lifestyle. Healthy habits like appropriate nutritional approaches or the consumption of certain natural products or food supplements have been suggested as non-pharmacological strategies for the treatment and prevention of type 2 diabetes. Some of the main bioactive compounds from plant foo...
#2Li Xu (Henan University)
Last. Peiren Wang (Henan University)
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Renal fibrosis is a major pathological event in the development of diabetic nephropathy (DN). Baicalin is a flavonoid glycoside that possesses multiple pharmacological properties including anti-fibrotic activity. In the present study, the effects of baicalin on renal fibrosis along with related molecular basis were investigated in streptozotocin (STZ)-induced DN mouse model and high glucose (HG)-treated HK-2 human proximal tubule epithelial cell model. Renal injury was evaluated through blood ur...
#1Feidan Gao (ZJU: Zhejiang University)H-Index: 3
#2Jie Zhang (ZJU: Zhejiang University)H-Index: 3
Last. Jufang Chi (ZJU: Zhejiang University)H-Index: 5
view all 8 authors...
Homocysteine (Hcy) is considered an independent risk factor for various cardiovascular diseases including atherosclerosis which is associated with lipid metabolism, inflammation, and oxidative stress. Results from our previous study suggested that Hcy-induced atherosclerosis could be reversed by Herpud1 knockout which inhibits vascular smooth muscle cell (VSMC) phenotype switching. Here, we aim to investigate more precise mechanisms behind the improvement in Hcy-induced atherosclerosis. Amyloid-...
#1Dalia G. Mostafa (King Khalid University)H-Index: 4
#2Huda H. Satti (King Khalid University)H-Index: 1
Last. Rehab M. Badi (King Khalid University)H-Index: 2
view all 4 authors...
The increase in osteopontin (OPN) levels after stroke induces neural protection by activating Akt signaling and inhibiting GS3Kβ, iNOS, and NF-κB. This study investigated the effect of a high-fat diet rich in corn oil (CO-HFD) on infarct size and memory function in rats after induction of cerebral ischemia in rats and investigated its effect on the expression of OPN/Akt/iNOS/NF-κB signaling pathways. Rats were initially fed a standard diet (STD, 3.82 kcal/g; 9.4%, from fat) or a CO-HFD (5.4 kcal...
Top fields of study
Oxidative stress
Diabetes mellitus