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Value in Health
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#2Dmitry DukhovnyH-Index: 13
Last. Shawn FayerH-Index: 3
view all 32 authors...
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#1Hélène E. Aschmann (UZH: University of Zurich)H-Index: 2
#2Cynthia M. Boyd (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 42
Last. Bruce A Leff (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 24
view all 15 authors...
Abstract Objectives In a previous project aimed at informing patient-centered care for people with multiple chronic conditions, we performed highly stratified quantitative benefit–harm assessments for 2 top priority questions. In this current work, our goal was to describe the process and approaches we developed and to qualitatively glean important elements from it that address patient-centered care. Methods We engaged patients, caregivers, clinicians, and guideline developers as stakeholder rep...
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#1Julia R. Trosman (UCSF: University of California, San Francisco)H-Index: 9
#2Michael P. Douglas (UCSF: University of California, San Francisco)H-Index: 15
Last. Kathryn A. Phillips (UCSF: University of California, San Francisco)H-Index: 44
view all 7 authors...
Abstract Objectives To examine the temporal trajectory of insurance coverage for next-generation tumor sequencing (sequencing) by private US payers, describe the characteristics of coverage adopters and nonadopters, and explore adoption trends relative to the Centers for Medicare and Medicaid Services’ National Coverage Determination (CMS NCD) for sequencing. Methods We identified payers with positive coverage (adopters) or negative coverage (nonadopters) of sequencing on or before April 1, 2019...
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#1Richard Norman (Curtin University)H-Index: 21
#2Jan Abel Olsen (University of Tromsø)H-Index: 29
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#1Christopher Carroll (University of Sheffield)H-Index: 29
#2Andrew J. Tattersall (University of Sheffield)H-Index: 15
Abstract Objectives Health technology assessment aims to inform and support healthcare decision making, and trials are part of that process. The purpose of this study was to measure the impact of a sample of trials in a meaningful but robust fashion. Methods All randomized controlled trials funded and published by the UK National Institute of Health Research in the Health Technology Assessment journal series and other peer-reviewed journals were identified for 2006 to 2015. Citation analysis was...
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#1Mónica Hernández Alava (University of Sheffield)H-Index: 13
#2Stephen Pudney (University of Sheffield)H-Index: 23
Last. Allan Wailoo (University of Sheffield)H-Index: 30
view all 3 authors...
Abstract Objectives Five-level EuroQol 5-dimensional questionnaire (EQ-5D-5L) values for several countries now exist. Decision makers require confidence in the underlying data and statistical analyses before advocating their use. Independent quality assurance of the published English value set is reported here. Methods Data from 996 participants, and code to run published statistical models, were provided for inspection. The main elements of the study were 10 lead-time trade-off (TTO) experiment...
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#1Michael Fralick (U of T: University of Toronto)H-Index: 11
#2Joshua J. Gagne (Brigham and Women's Hospital)H-Index: 30
Last. Aaron S. Kesselheim (Brigham and Women's Hospital)H-Index: 42
view all 5 authors...
Abstract Objectives Outcomes-based contracts tie rebates and discounts for expensive drugs to outcomes. The objective was to estimate the utility of outcomes-based contracts for diabetes medications using real-world data and to identify methodologic limitations of this approach. Methods A population-based cohort study of adults newly prescribed a medication for diabetes with a publicly announced outcomes-based contract (ie, exenatide microspheres [“exenatide”], dulaglutide, or sitagliptin) was c...
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#1Rebecca Hall (Adelphi University)H-Index: 1
#2Claire Trennery (Adelphi University)
Last. L. Nelsen (GSK: GlaxoSmithKline)
view all 9 authors...
Abstract Objectives To qualitatively explore patient experiences of severe, recurrent, bilateral nasal polyps (NP). Methods A targeted literature review of published qualitative studies and online blogs describing patient experiences of NP was conducted. Semistructured concept elicitation interviews were conducted in the United States and Germany with participants ≥18 years with severe, recurrent, bilateral NP to explore their symptom experience and impacts on health-related quality of life (HRQ...
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#1Khachen Kongpakwattana (Monash University Malaysia Campus)H-Index: 3
#2Nathorn Chaiyakunapruk (Monash University Malaysia Campus)H-Index: 25
Abstract Objectives Decision-analytic models for Alzheimer’s disease (AD) have been advanced to a discrete-event simulation (DES), in which individual-level modeling of disease progression across continuous severity spectra become feasible. This study aimed to apply DES to perform cost-effectiveness analysis of AD treatment in Thailand. Methods A data set of Thai AD patients, representing unique demographic and clinical characteristics, was bootstrapped to generate a baseline cohort of 50 000 pa...
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#1Paul Allanson (Dund.: University of Dundee)H-Index: 14
#2Eric A. Brown (Dund.: University of Dundee)
Last. A. Kwiatkowski (Dund.: University of Dundee)H-Index: 1
view all 4 authors...
Abstract Objectives The usefulness of discrete choice experiments (DCEs) to inform clinical guidelines rests on the assumption that patients facing the same treatment choice at different points in time will express the same preferences. This study provides the first investigation, to our knowledge, to specifically focus on the stability of patients’ treatment preferences over the course of a clinical trial. Methods The same DCE was completed by participants at baseline and final post-treatment a...
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