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Experimental Diabetes Research
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#1Mary Byrn (LUC: Loyola University Chicago)H-Index: 6
#2William Adams (LUC: Loyola University Chicago)H-Index: 10
Last.Mary Ann Emanuele (LUC: Loyola University Chicago)H-Index: 25
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Aim. Type 2 diabetes increases the risk of cognitive decline which adversely impacts self-management of the disease. Evidence also supports a relationship between low serum 25(OH)D levels and poor cognition. The purpose of this trial was to assess vitamin D supplementation on cognitive executive functioning in persons living with type 2 diabetes. Methods. This was a double-blinded RCT where participants were randomized to receive either weekly vitamin D3 supplementation (50,000 IUs) or a matchin...
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#1Yan Duan (Capital Medical University)H-Index: 1
#2Xiaomeng Sun (Capital Medical University)H-Index: 1
Last.Guang Wang (Capital Medical University)H-Index: 9
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Aims/Introduction. This study is aimed at (1) investigating the change of β-cell dysfunction as baseline fasting glucose progresses in newly diagnosed patients with T2DM and (2) finding whether body mass index (BMI) has different degrees of impact on insulin secretion as baseline fasting glucose progresses. Materials and Methods. 661 patients with newly diagnosed T2DM were enrolled in the present study. A 75 g oral glucose tolerance test was used to calculate HOMA-β, HOMA-IR, early-phase insulin...
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#1Jian Song (Bengbu Medical College)H-Index: 1
#2Xue Chen (Bengbu Medical College)H-Index: 1
Last.Huaiquan Gao (Bengbu Medical College)H-Index: 1
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Aims. Lipid accumulation product (LAP) is put forward as a powerful marker showing the accumulation of visceral fat. The present study is aimed at (i) analyzing the predictive performances of LAP in the identification of impaired fasting glucose (IFG) in Chinese population and (ii) exploring the potentially interactive effect between LAP and other factors on IFG risk. Methods. Analysis was conducted on the data obtained from a community-based cross-sectional survey in Chinese population, and all...
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#1Jie Wang (NKU: Nankai University)
#2Xinye Jin (Chinese PLA General Hospital)
Last.Yiming Mu (NKU: Nankai University)
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Background. In patients with type 2 diabetes mellitus (T2DM) and poor glycemic control receiving metformin (MET), glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are recommended as the adjunctive therapy. However, there are only a few studies involving the comparative effects of exenatide twice a day (EXBID) and exenatide once weekly (EXQW) on HOMA-β. This meta assessed the comparative effects of EXQW and EXBID on HOMA-β among T2DM patients. Materials and Methods. PubMed, Cochrane Library,...
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#1Jerzy Hohendorff (Jagiellonian University Medical College)H-Index: 3
#2Anna Drożdż (Jagiellonian University)H-Index: 3
Last.Maciej T. Malecki (Jagiellonian University Medical College)H-Index: 33
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Background and Aims. Diabetic foot ulcers (DFUs) are linked to amputations and premature deaths. Negative pressure wound therapy (NPWT) has been used for DFUs. The mechanism of NPWT’s action may be associated with its influence on circulating molecules. We assessed NPWT’s effect on the plasma levels of angiopoietin-2 (Ang2), a key regulator of angiogenesis, and its microvesicular receptors (Tie2) as well as the microvesicles (MVs) themselves in DFU patients. Materials and Methods. We included 69...
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Background. ANGPTL4 is a glycoprotein that is involved in regulating triglyceride metabolism by inhibiting LPL activity under fasting conditions. Additionally, ANGPTL4 has been suggested as a link between hypertriglyceridemia and albuminuria in the nephrotic syndrome. In this study, we examined levels of circulating ANGPTL4 in people with diabetic nephropathy (DN) and its association with established DN-associated proteins such as IGFBP1 and IGFBP4. Methods. We quantified circulating ANGPTL4, IG...
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Type 1 diabetes (T1D) is an autoimmune disease caused by the destruction of pancreatic β cells by autoantigen-reactive diabetogenic cells. Antigen-specific therapies using islet autoantigens for restoring immune tolerance have emerged as promising approaches for the treatment of T1D but have been unsuccessful in humans. Herein, we report that RGI-3100-iB, a novel liposomal formulation carrying both α-galactosylceramide (α-GalCer), which is a representative ligand for invariant natural killer T (...
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#1Thongchai Pratipanawatr (KKU: Khon Kaen University)H-Index: 8
#2Bancha SatirapojH-Index: 12
Last.Wannee Nitiyanant (Siriraj Hospital)H-Index: 4
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Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases. Patients are generally advised lifestyle changes with antihyperglycemic agents prescribed. The major drawback of prescribing antihyperglycemic agents is the risk of hypoglycemia which subsequently impacts on health-related quality of life (HRQoL). This study is aimed at examining association between previous history of hypoglycemia and HRQoL. The study was a multicenter cross-sectional study, conducted from February 2013...
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#1Guangyong Ye (ZJU: Zhejiang University)H-Index: 1
#2Long Zhang (ZJU: Zhejiang University)
Last.Xinyou Xie (ZJU: Zhejiang University)
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Gestational diabetes mellitus (GDM) is prevalent worldwide, leading to a high risk of significant morbidity for both the mother and offspring with complications. Increasing evidences suggest that gut microbiota plays a role in the pathogenesis of GDM. Lifestyle modification is the cornerstones of GDM treatment. However, a number of patients whose blood glucose is not controlled by lifestyle modification still require exogenous insulin to control blood glucose. No observational study is available...
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#1Meera Ladwa ('KCL': King's College London)
#2Olah Hakim ('KCL': King's College London)H-Index: 2
Last.Louise M. Goff ('KCL': King's College London)H-Index: 13
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Background. Understanding ethnic differences in beta cell function has important implications for preventative and therapeutic strategies in populations at high risk of type 2 diabetes (T2D). The existing literature, largely drawn from work in children and adolescents, suggests that beta cell function in black African (BA) populations is upregulated when compared to white Europeans (WE). Methods. A systematic literature search was undertaken in June 2018 to identify comparative studies of beta c...
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Top fields of study
Endocrinology
Type 2 diabetes
Insulin
Diabetes mellitus
Medicine