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Advances in Protein Chemistry
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#1D. Thirumal Kumar (VIT University)H-Index: 10
#2D Thirumal Kumar (VIT University)H-Index: 1
Last.Hatem Zayed (Qatar University)H-Index: 13
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Abstract The DNA repair system is crucial to repair the error resulting in DNA replication. MSH2-MSH6 protein complex plays a significant role in maintaining the mismatch repair mechanism. Mutations in the interface between the two proteins compromise their function in the repair process. The present study aims to understand the impact of missense mutations in the interacting sites of the MSH2-MSH6 protein complex. MSH6 is unstable due to the disordered N-terminal domain. This is stabilized by t...
#1Shibani Mukherjee (UTSW: University of Texas Southwestern Medical Center)H-Index: 21
#2Salim Abdisalaam (UTSW: University of Texas Southwestern Medical Center)H-Index: 7
Last.Aroumougame Asaithamby (UTSW: University of Texas Southwestern Medical Center)H-Index: 21
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Abstract Previously, DNA damage sensing, repairing and signaling machineries were thought to mainly suppress genomic instability in response to genotoxic stress. Emerging evidence indicates a crosstalk between DNA repair machinery and the immune system. In this chapter, we attempt to decipher the molecular choreography of how factors, including ATM, BRCA1, DNA-PK, FANCA/D2, MRE11, MUS81, NBS1, RAD51 and TREX1, of multiple DNA metabolic processes are directly or indirectly involved in suppressing...
#1Maxim Sokolov (WVU: West Virginia University)H-Index: 13
#2Ravi P. Yadav (Roy J. and Lucille A. Carver College of Medicine)H-Index: 4
Last.Nikolai O. Artemyev (Roy J. and Lucille A. Carver College of Medicine)H-Index: 30
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Abstract Defects in protein folding and trafficking are a common cause of photoreceptor degeneration, causing blindness. Photoreceptor cells present an unusual challenge to the protein folding and transport machinery due to the high rate of protein synthesis, trafficking and the renewal of the outer segment, a primary cilium that has been modified into a specialized light-sensing compartment. Phototransduction components, such as rhodopsin and cGMP-phosphodiesterase, and multimeric ciliary trans...
#1Margherita SistoH-Index: 20
#2Domenico RibattiH-Index: 80
Last.Sabrina LisiH-Index: 21
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Abstract Aquaporins (AQPs) are a family of membrane water channel proteins that osmotically modulate water fluid homeostasis in several tissues; some of them also transport small solutes such as glycerol. At the cellular level, the AQPs regulate not only cell migration and transepithelial fluid transport across membranes, but also common events that are crucial for the inflammatory response. Emerging data reveal a new function of AQPs in the inflammatory process, as demonstrated by their dysregu...
#1Nathalie FuentesH-Index: 1
#2Patricia SilveyraH-Index: 14
Abstract The primary female sex hormones, estrogens, are responsible for the control of functions of the female reproductive system, as well as the development of secondary sexual characteristics that appear during puberty and sexual maturity. Estrogens exert their actions by binding to specific receptors, the estrogen receptors (ERs), which in turn activate transcriptional processes and/or signaling events that result in the control of gene expression. These actions can be mediated by direct bi...
#1Z. Begum Yagci (Boğaziçi University)H-Index: 1
#2Elif Esvap (Boğaziçi University)
Last.Elif Ozkirimli Olmez (Boğaziçi University)H-Index: 4
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Abstract Lysosome is the organelle responsible for breaking down macromolecules to maintain homeostasis and to fight infection. The disruption of normal lysosomal function due to mutations in the sphingolipid metabolism proteins leads to a class of lysosomal storage diseases (LSDs). Defective autophagy and activation of inflammation are observed in most LSDs. The crosstalk between these key metabolic pathways suggests that therapeutic approaches used in the treatment of LSDs may provide anti-inf...
#1Pepijn M. Schoonen (UMCG: University Medical Center Groningen)H-Index: 4
#2Sergi Guerrero Llobet (UMCG: University Medical Center Groningen)H-Index: 2
Last.Rossen DonevH-Index: 19
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Abstract Genomically instable cancers are characterized by progressive loss and gain of chromosomal fragments, and the acquisition of complex genomic rearrangements. Such cancers, including triple-negative breast cancers and high-grade serous ovarian cancers, typically show aggressive behavior and lack actionable driver oncogenes. Increasingly, oncogene-induced replication stress or defective replication fork maintenance is considered an important driver of genomic instability. Paradoxically, wh...
#1Eduard Stefan (University of Innsbruck)H-Index: 19
#2Jakob Troppmair (Innsbruck Medical University)H-Index: 43
Last.Klaus Bister (University of Innsbruck)H-Index: 32
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Abstract The architectures of central signaling hubs are precisely organized by static and dynamic protein–protein interactions (PPIs). Upon deregulation, these PPI platforms are capable to propagate or initiate pathophysiological signaling events. This causes the acquisition of molecular features contributing to the etiology or progression of many diseases, including cancer, where deregulated molecular interactions of signaling proteins have been best studied. The reasons for PPI-dependent repr...
#1Ilkcan Ercan (Dokuz Eylül University)H-Index: 1
#2Kemal Ugur Tufekci (Dokuz Eylül University)H-Index: 7
Last.Kursad Genc (Dokuz Eylül University)H-Index: 23
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Abstract During the past 35 years, recombinant DNA technology has allowed the production of a wide range of hematopoietic and neurotrophic growth factors including erythropoietin (EPO). These have emerged as promising protein drugs in various human diseases. Accumulated evidences have recently demonstrated the neuroprotective effect of EPO in preclinical models of acute and chronic degenerative disorders. Nevertheless, tissue protective effect of EPO could not be translated to the clinical trial...
#1Marlon H. Cardoso (UCB: Universidade Católica de Brasília)H-Index: 8
#2Karen G. N. Oshiro (UCDB: Universidade Católica Dom Bosco)H-Index: 2
Last.Octávio L. Franco (UCB: Universidade Católica de Brasília)H-Index: 29
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Abstract Antimicrobial peptides (AMPs) have been widely isolated from most organisms in nature. This class of antimicrobials may undergo changes in their sequence for improved physicochemical properties, including charge, hydrophobicity, and hydrophobic moment. It is known that such properties may be directly associated with AMPs’ structural arrangements and, consequently, could interfere in their modes of action against microorganisms. In this scenario, biophysical methodologies, such as nuclea...
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