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Laboratory Animals
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#1Luca Bellini (UNIPD: University of Padua)H-Index: 3
#2Giulia Maria De Benedictis (UNIPD: University of Padua)H-Index: 7
Few reports evaluate the clinical effects of opioids in sheep during experimental surgical procedures. Catecholamine-mediated haemodynamic changes resulting from surgical noxious stimulation are blunted by opioids. The aim of this study was to evaluate the efficacy of three opioid-based analgesic protocols in avoiding a 20% increase in heart rate (HR) and/or mean arterial blood pressure (MAP) during experimental intervertebral disk nucleotomy in sheep. Eighteen female Brogna sheep were anaesthet...
#1Laurentiu Benga (HHU: University of Düsseldorf)H-Index: 5
#2Andrea T. Feßler (FU: Free University of Berlin)H-Index: 17
Last.Martin Sager (HHU: University of Düsseldorf)H-Index: 22
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There are different husbandry situations that lead to social isolation of male mice. Besides legal considerations, single housing has a negative impact on behavioural and molecular studies. We have implemented two strategies, the ‘companion mouse’ and just-weaned male grouping, to reduce the number of male mice housed singly in our facility. We have achieved a progressive reduction (42% in three years) without an increase in aggression.
#1C Bauer (TUM: Technische Universität München)
#2U Schillinger (TUM: Technische Universität München)
Last.Christine Baumgartner (TUM: Technische Universität München)H-Index: 7
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In accordance with the ‘refinement’ component of the 3Rs, the primary aim of this study was to investigate and compare ketamine + medetomidine (KM) and s-ketamine + medetomidine (SKM) anaesthetic protocols in C57BL/6J mice (both sexes). We sought to determine whether s-ketamine could provide adequate surgical tolerance at a 50% dose relative to that of ketamine racemate and whether antagonism of medetomidine could be initiated 15 min earlier. The second aim was to investigate the potential impro...
The genetic and biological similarity between non-human primates and humans has ensured the continued use of primates in biomedical research where other species cannot be used. Health-monitoring programmes for non-human primates provide an approach to monitor and control both endemic and incoming agents that may cause zoonotic and anthroponotic disease or interfere with research outcomes. In 1999 FELASA recommendations were published which aimed to provide a harmonized approach to health monitor...
#1Davide De Biase (University of Naples Federico II)H-Index: 4
#2Francesco Esposito (University of Naples Federico II)H-Index: 23
Last.Alfredo Fusco (University of Naples Federico II)H-Index: 78
view all 10 authors...
Ulcerative dermatitis (UD) is an idiopathic, spontaneous and progressive disease typically affecting C57BL/6 aged mice with an unknown aetiopathogenesis. For this study, we evaluated 25 cases of UD in C57BL/6NCrl-Tg(HMGA1P6)1Pg mice. Formalin-fixed, paraffin-embedded skin samples were submitted to morphological investigations. Immunohistochemical analysis was performed to characterize and quantify inflammatory cells using CD3, CD45/B220, CD4, CD8 and IL-17 antibodies. Mast cell-bound IgE was inv...
#1Cristóbal Carvajal (Universidad del Desarrollo)H-Index: 4
#2Catalina Vallejos (Universidad del Desarrollo)
Last.Sebastián D. Calligaris (Universidad del Desarrollo)H-Index: 7
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Research studies involving animal experimentation are regulated by the Institutional Animal Care and Use Committee (IACUC). To this end, the IACUC must integrate the information provided by the investigators of each preclinical study and the veterinarians from the animal facility in order to monitor and approve the process. Using a paper-based system to collect animal health and welfare data is a common, albeit time-consuming practice, prone to transcription and reading errors, not to mention in...
#1Junghoon YuH-Index: 1
#2Jinkyoo MoonH-Index: 2
Last.Minyoung KimH-Index: 15
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Stroke is one of the leading causes of death and disability worldwide, and its incidence is increasing. To overcome impairment from stroke, translational research for developing new therapeutic technologies has been conducted and middle cerebral artery occlusion (MCAo) in rat is the representative model. Since recovery from neurological impairment in contralateral limbs caused by brain damage is the major goal of treatment, behavioral tests that assess the relevant function are used. To determin...
#1N. Madrahimov (MHH: Hannover Medical School)H-Index: 4
#2Ruslan Natanov (MHH: Hannover Medical School)H-Index: 1
Last.Axel Haverich (MHH: Hannover Medical School)H-Index: 79
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