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Current Pharmaceutical Design
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Last. Evelyn Mendoza-Torres (Free University of Colombia)H-Index: 1
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Ischemic heart disease is the main cause of death globally. In the heart, the ischemia/reperfusion injury gives rise to a complex cascade of molecular signals, called cardiac remodeling, which generates harmful consequences for the contractile function of the myocardium and consequently heart failure. Metformin is the drug of choice in the treatment of type 2 diabetes mellitus. Clinical data suggest the direct effects of this drug on cardiac metabolism and studies in animal models showed that me...
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#1Alireza Milani (Pasteur Institute of Iran)H-Index: 4
#2Parya Basimi (Pasteur Institute of Iran)
Last. Azam Bolhassani (Pasteur Institute of Iran)H-Index: 18
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Many studies have been performed to develop an antiviral therapy against the hepatitis C virus (HCV) infections. The usual treatment for HCV infection is a combination of PEGylated interferon and ribavirin which offer restricted efficiency and major side effects. Thus, recent development in molecular biology of HCV and its life cycle led to the design of many drugs that target viral proteins and host factors required for viral replication. These drugs were named as direct-acting antivirals (DAAs...
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#1Mária A. DeliH-Index: 36
#2Andrej Kovac (SAV: Slovak Academy of Sciences)H-Index: 15
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#1Carlos Beas-Zarate (University of Guadalajara)H-Index: 22
#2Antoni Camins (University of Barcelona)H-Index: 40
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#1Chih-Hsien Cheng (CGU: Chang Gung University)H-Index: 5
#2Chen-Fang Lee (CGU: Chang Gung University)H-Index: 15
Last. Wei-Chen Lee (CGU: Chang Gung University)H-Index: 28
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ABO-incompatible (ABO-I) liver transplantation (LT) has been limited due to the increased rate of complications, including severe cellular and antibody-mediated rejection, hepatic necrosis, hepatic artery thrombosis, and biliary complications. However, several strategies for reducing preformed anti-donor ABO antibodies and B cell desensitization have improved the outcomes of ABO-I LT. As a result, ABOI LT has become a routine procedure and is a feasible option in countries with scarce deceased-o...
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#1Giulia Lisi (University of Rome Tor Vergata)H-Index: 3
#2Michele Ribolsi (University of Rome Tor Vergata)H-Index: 12
Last. Cinzia Niolu (University of Rome Tor Vergata)H-Index: 12
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There is evidence that mental health disorders may have roots in fetal life and are associated with deficiencies in various micronutrients, including vitamin D. During pregnancy, vitamin D homeostasis is influenced by an increase in maternal calcitriol and a substantial increase in maternal Vitamin D Binding Protein concentrations. In the early stages of life, vitamin D is necessary to mediate numerous brain processes such as proliferation, apoptosis, and neurotransmission. Furthermore, Vitamin ...
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#1Zeinab Nazarian-Samani (TMU: Tarbiat Modares University)
#2Robert David Edmund Sewell (Cardiff University)H-Index: 22
Last. M Rafieian Kopaie (Shahrekord University of Medical Sciences)H-Index: 38
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Chronic inflammation plays an extensive role in the onset and progression of metabolic disorders such as atherosclerosis, type 2 diabetes, gout and obesity. Atherosclerosis accounts for upwards of 70% mortality in patients with type 2 diabetes and is also a chronic condition that causes atrial stenosis due to a lipometabolism imbalance. The purpose of this article is to consider the inflammatory factors implicated in atherosclerosis and their role in the development and progression of this vascu...
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BACKGROUND: The increased bone loss after spinal cord injury (SCI) is associated with an increase in the morbidity and mortality of fragility fractures, which can constitute a substantial cost to health care systems. Bisphosphonates (BPs) are now the principal class of medications used for osteoporosis. OBJECTIVE: To demonstrate the effect of BPs on treating osteoporosis after SCI. METHODS: A comprehensive search in the PubMed, EMBASE, Web of Science and Cochrane Central databases was undertaken...
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#1Pegah Nammian (Shiraz University of Medical Sciences)
#2Vahid Razban (Shiraz University of Medical Sciences)H-Index: 6
Last. Seyedeh-Leili Asadi-Yousefabad (Shiraz University of Medical Sciences)H-Index: 2
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BACKGROUND: MicroRNA-126, a microRNA implicated in blood vessel integrity and angiogenesis is significantly up/down regulated in different physiological and pathological conditions related to angiogenesis such as cardiovascular formation and angiogenesis dependent diseases like Cancer, diabetic microvascular complication, cardiovascular disease, atherosclerosis and stroke. MicroRNA-126 plays a critical role in angiogenesis via regulating the proliferation, differentiation, migration, and apoptos...
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#1Gabriella Amorese (UniPi: University of Pisa)H-Index: 17
#2Carlo Lombardo (UniPi: University of Pisa)H-Index: 5
Last. Ugo Boggi (UniPi: University of Pisa)H-Index: 37
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BACKGROUND: Despite improved overall outcomes rejection continues to occur frequently after pancreas transplantation. OBJECTIVE: To review the literature and to provide a state-of-the-art assessment of current practice and developments of immunosuppressive regimens in pancreas transplantation. METHODS: The English literature was reviewed. Relevant articles were retrieved and analysed. RESULTS: Induction therapy is used in approximately 90% of the transplants, with T-cell depleting antibodies bei...
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