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BMC Biotechnology
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2.30
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Papers 1453
1 page of 146 pages (1,453 results)
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#1Aiyou Huang (CAS: Chinese Academy of Sciences)H-Index: 8
#2Songcui Wu (CAS: Chinese Academy of Sciences)H-Index: 5
Last.Guang-CeWANG (CAS: Chinese Academy of Sciences)H-Index: 24
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Background Increasing CO2 emissions have resulted in ocean acidification, affecting marine plant photosynthesis and changing the nutrient composition of marine ecosystems. The physiological and biochemical processes of marine phytoplankton in response to ocean acidification have been reported, but have been mainly focused on growth and photosynthetic physiology. To acquire a thorough knowledge of the molecular regulation mechanisms, model species with clear genetic background should be selected ...
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#1Henrique César Teixeira Veras (UnB: University of Brasília)H-Index: 2
#2Christiane Gonçalves Campos (UFG: Universidade Federal de Goiás)H-Index: 2
Last.Nádia Skorupa Parachin (UnB: University of Brasília)H-Index: 12
view all 6 authors...
Efficient xylose fermentation still demands knowledge regarding xylose catabolism. In this study, metabolic flux analysis (MFA) and metabolomics were used to improve our understanding of xylose metabolism. Thus, a stoichiometric model was constructed to simulate the intracellular carbon flux and used to validate the metabolome data collected within xylose catabolic pathways of non-Saccharomyces xylose utilizing yeasts. A metabolic flux model was constructed using xylose fermentation data from ye...
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#1Yang Gao (NWAFU: Northwest A&F University)
#2Feng Feng Sang (NWAFU: Northwest A&F University)
Last.De Kun Chen (NWAFU: Northwest A&F University)
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Background Interleukin-17 (IL-17), the characteristic cytokine secreted by T helper 17 lymphocytes (Th17 cells), plays a pivotal role in host defense and many inflammatory or autoimmune diseases. The aim of this study was to obtain purified protein caprine IL-17A (cIL-17A) as an antigen for preparing an IL-17A-specific monoclonal antibody (mAb).
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#1Kayla Carey (VT: Virginia Tech)H-Index: 1
#2Junghyun Ryu (VT: Virginia Tech)H-Index: 6
Last.Kiho Lee (VT: Virginia Tech)H-Index: 7
view all 7 authors...
Background The CRISPR/Cas9 system can effectively introduce site-specific modifications to the genome. The efficiency is high enough to induce targeted genome modifications during embryogenesis, thus increasing the efficiency of producing genetically modified animal models and having potential clinical applications as an assisted reproductive technology. Because most of the CRISPR/Cas9 systems introduce site-specific double-stranded breaks (DSBs) to induce site-specific modifications, a major co...
1 CitationsSource
#1Matthew P. A. Bellefleur (UF: University of Florida)H-Index: 1
#2Soo-Young Wanda (UF: University of Florida)H-Index: 1
Last.Roy Curtiss (UF: University of Florida)H-Index: 9
view all 3 authors...
Synechocystis sp. PCC 6803 is a photosynthetic bacterium that has been genetically modified to produce industrially relevant chemicals, yet efflux mechanisms have not been well elucidated. These photosynthetic organisms live in environments that are often nutrient limited; therefore, the genome of these organisms encodes far fewer proteins used for efflux of chemicals when compared to members of the Enterobacteriaceae family. Understanding efflux mechanisms can lead to a greater efficiency of ch...
1 CitationsSource
#1Guilherme Souza Prado (UCB: Universidade Católica de Brasília)H-Index: 2
#2Pingdwende Kader Aziz Bamogo (University of Montpellier)
Last.Séverine Lacombe (University of Montpellier)H-Index: 1
view all 13 authors...
Insect resistance in crops represents a main challenge for agriculture. Transgenic approaches based on proteins displaying insect resistance properties are widely used as efficient breeding strategies. To extend the spectrum of targeted pathogens and overtake the development of resistance, molecular evolution strategies have been used on genes encoding these proteins to generate thousands of variants with new or improved functions. The cotton boll weevil (Anthonomus grandis) is one of the major ...
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CRISPR/Cas9 has wide application potentials in a variety of biological species including Trichoderma reesei, a filamentous fungus workhorse for cellulase production. However, expression of Cas9 heterologously in the host cell could be time-consuming and sometimes even troublesome. We tested two gene disruption methods in T. reesei using CRISPR/Cas9 in this study. The intracellularly expressed Cas9 led to unexpected off-target gene disruption in T. reesei QM9414, favoring inserting 9- or 12-bp at...
4 CitationsSource
#1Michela Flego (ISS: Istituto Superiore di Sanità)H-Index: 9
#2Aldo Frau (University of Cagliari)H-Index: 3
Last.Enzo Tramontano (University of Cagliari)H-Index: 28
view all 10 authors...
Ebola hemorrhagic fever is caused by the Ebola filovirus (EBOV), which is one of the most aggressive infectious agents known worldwide. The EBOV pathogenesis starts with uncontrolled viral replication and subversion of both the innate and adaptive host immune response. The multifunctional viral VP35 protein is involved in this process by exerting an antagonistic action against the early antiviral alpha/beta interferon (IFN-α/β) response, and represents a suitable target for the development of st...
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#1Jian Pang (Inner Mongolia University of Technology)H-Index: 1
#2Junshu Wang (SDU: Shandong University)
Last.Qingsheng Qi (SDU: Shandong University)H-Index: 27
view all 5 authors...
Background In the previous study, the cellulolytic Escherichia coli ZH-4 isolated from bovine rumen was found to show extracellular cellulase activity and could degrade cellulose in the culture. The goal of this work was to identify and characterize the secreted cellulase of E. coli ZH-4. It will be helpful to re-understand E. coli and extend its application in industry.
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#1Guiqi ZhangH-Index: 1
#2Yi LiuH-Index: 1
Last.Wei-Bing XuH-Index: 1
view all 6 authors...
Spinal cord injury (SCI) remains a huge medical problem nowadays as there is no hospital providing the versatile strategies for repairing central nervous system and restoring function. Herein, we focused on PC-12 cells as an important research tool and studied the potential role of resveratrol (RSV) in inflammation induced by LPS. RSV improved inflammatory injury and functional recovery in rat model of SCI. RSV inhibited LPS-induced inflammatory injury in PC-12 cells via increasing viability, de...
3 CitationsSource
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