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Journal of Biomedical Science
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Papers 2338
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#1Fu-Chen Yang (NYMU: National Yang-Ming University)H-Index: 1
#2Po-Yuan Chiu (NYMU: National Yang-Ming University)H-Index: 1
Last.Nien-Jung Chen (NYMU: National Yang-Ming University)H-Index: 18
view all 5 authors...
Triggering receptor expressed on myeloid cells-1 (TREM-1) is highly expressed on macrophages in inflamed intestines and reportedly promotes inflammatory bowel disease (IBD) by augmenting pro-inflammatory responses. To study the mechanism mediated by TREM-1 on macrophages, we generated an independent TREM-1 deficient mouse. Acute colitis was induced in C57BL/6 and TREM-1-deficient mice by the administration of dextran sodium sulfate (DSS). Colonic lamina propria immune cell composition and cytoki...
1 CitationsSource
#1I-Ying Kuo (NCKU: National Cheng Kung University)H-Index: 6
#2Yu-Lin Huang (NCKU: National Cheng Kung University)H-Index: 2
Last.Yi-Ching Wang (NCKU: National Cheng Kung University)H-Index: 28
view all 7 authors...
Prognosis of esophageal squamous cell carcinoma (ESCC) patients is poor and the concurrent chemoradiation therapy (CCRT) provided to ESCC patients often failed due to resistance. Therefore, development of biomarkers for predicting CCRT response is immensely important. In this study, we evaluated the predicting value of SRY (sex determining region Y)-box 17 (SOX17) protein during CCRT and its dysregulation of transcriptional targets in CCRT resistance in ESCC. Pyrosequencing methylation, RT-qPCR ...
2 CitationsSource
#1Wenxia Meng (Hebei Medical University)H-Index: 2
#2Weina Cui (Hebei Medical University)H-Index: 2
Last.Baoshan Wang (Hebei Medical University)H-Index: 4
view all 6 authors...
Background Dysregulated long noncoding RNAs (lncRNAs) are involved in the development of tumor. Aberrant methylation is one of the most frequent epigenetic alterations that regulate the expression of genes. The aim of this study was to determine the expression and methylation status of ZNF667-AS1 and ZNF667, elucidate their biological function in the development of LSCC, and identify a cis-regulation of ZNF667-AS1 to ZNF667.
5 CitationsSource
#1Andre G. Buret (U of C: University of Calgary)H-Index: 47
#2Jean-Paul Motta (University of Toulouse)H-Index: 15
Last.John L. Wallace (U of C: University of Calgary)H-Index: 71
view all 5 authors...
Gut microbiota interacting with an intact mucosal surface are key to the maintenance of homeostasis and health. This review discusses the current state of knowledge of the biofilm mode of growth of these microbiota communities, and how in turn their disruptions may cause disease. Beyond alterations of relative microbial abundance and diversity, the aim of the review is to focus on the disruptions of the microbiota biofilm structure and function, the dispersion of commensal bacteria, and the mech...
7 CitationsSource
Enterovirus 71 (EV71 or EV-A71) was first identified in California about half a century ago. In recent years, outbreaks of EV-A71 were prevalent worldwide, including Taiwan, Malaysia, Singapore, Japan, and China. Between 2008 and 2011, China alone reported 1894 deaths associated with EV-A71 infection. In mild cases, EV-A71 can cause herpangina and hand-foot-and-mouth disease (HFMD). However, in severe cases, it could cause neurological disorders, including meningitis and encephalitis. Cardiopulm...
1 CitationsSource
#1Shu Yih Chew (UPM: Universiti Putra Malaysia)H-Index: 4
#2Wallace Jeng Yang Chee (UPM: Universiti Putra Malaysia)
Last.Leslie Thian Lung Than (UPM: Universiti Putra Malaysia)H-Index: 8
view all 3 authors...
Background Carbon utilization and metabolism are fundamental to every living organism for cellular growth. For intracellular human fungal pathogens such as Candida glabrata, an effective metabolic adaptation strategy is often required for survival and pathogenesis. As one of the host defence strategies to combat invading pathogens, phagocytes such as macrophages constantly impose restrictions on pathogens’ access to their preferred carbon source, glucose. Surprisingly, it has been reported that ...
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#1C-J Yen (NCKU: National Cheng Kung University)H-Index: 24
#2Shu Ting Yang (NCKU: National Cheng Kung University)H-Index: 5
Last.Liang-Yi HungH-Index: 15
view all 13 authors...
Our previous report suggested that centrosomal P4.1-associated protein (CPAP) is required for Hepatitis B virus (HBV) encoded non-structure protein X (HBx)-mediated nuclear factor kappa light chain enhancer of activated B cells (NF-κB) activation. CPAP is overexpressed in HBV-associated hepatocellular carcinoma (HCC); however, the interaction between CPAP and HBx in HBV-HCC remains unclear. The mRNA expression of CPAP and HBx was analyzed by quantitative-PCR (Q-PCR). NF-κB transcriptional activi...
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#1Junaida Osman (UKM: National University of Malaysia)H-Index: 1
#2Shing Cheng Tan (UKM: National University of Malaysia)H-Index: 1
Last.Rahman Jamal (UKM: National University of Malaysia)H-Index: 10
view all 5 authors...
Sudden cardiac death (SCD) is a sudden, unexpected death that is caused by the loss of heart function. While SCD affects many patients suffering from coronary artery diseases (CAD) and heart failure (HF), a considerable number of SCD events occur in asymptomatic individuals. Certain risk factors for SCD have been identified and incorporated in different clinical scores, however, risk stratification using such algorithms is only useful for health management rather than for early detection and pre...
1 CitationsSource
#1Sung Yong Lee (Korea University Medical Center)
#2Jee Youn Oh (KU: Korea University)
Last.Chien-Fu Hung (Johns Hopkins University)H-Index: 53
view all 8 authors...
Endoplasmic reticulum stress has a profound effect on cancer cell proliferation and survival, and also has the capacity to activate cells of the adaptive immune system. Multimodal treatment methods that utilize and combine conventional cancer therapies with antigen-specific immunotherapies have emerged as promising approaches for the treatment and control of cancer. However, it is not well known whether endoplasmic reticulum stress-inducing agents can influence the efficacy of tumor antigen-targ...
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Endocrinology
Molecular biology
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