The Journal of Rheumatology
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OBJECTIVE Whole-body MRI (WBMRI) is promising for monitoring patients' global disease activity in inflammatory joint diseases. The validation of WBMRI is limited; no studies have evaluated the test-retest agreement (interscan agreement) and only few have assessed the intra- and interreader agreement. Therefore we examined the interscan agreement of WBMRI in patients with psoriatic arthritis (PsA), rheumatoid arthritis (RA) and healthy controls (HC); and secondly evaluated the intraand interreade...
OBJECTIVE Early diagnosis of systemic sclerosis (SSc) is imperative and Raynaud's phenomenon (RP) is an important component of progressive vasculopathy. Nailfold videocapillaroscopy (NVC) is a wellestablished tool that can quantify structural vascular abnormalities. Digital thermal monitoring (DTM) assesses microvascular functional dysfunction related to thermoregulation. In this study, we investigated the correlation of NVC patterns and DTM variables in SSc patients. METHODS Patients with SSc b...
OBJECTIVE We assessed if the inverse OARSI-OMERACT criteria relate to concurrent radiographic knee osteoarthritis (KOA) progression and decline in walking speed as well as future knee replacement. METHODS We conducted knee-based analyses of data from the Osteoarthritis Initiative. All knees had symptomatic osteoarthritis: at least doubtful radiographic KOA (Kellgren-Lawrence Grade≥1) and knee pain≥10/100 (WOMAC pain) at the 12-month visit. The inverse of the OARSI-OMERACT responder criteria depe...
#1Andrew D. FoersH-Index: 4
Last. Ian P. WicksH-Index: 45
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OBJECTIVE To identify small non-coding RNA (sncRNA) serum biomarkers that predict response to triple disease-modifying antirheumatic drug (DMARD) therapy in patients with early rheumatoid arthritis (RA). METHODS Early RA patients entered into a treat-to-target management algorithm, with triple DMARD therapy (methotrexate + sulphasalazine + hydroxychloroquine). Patients were assessed following 6 months of therapy and classified as EULAR responders or non-responders. RNA was isolated from 42 archi...
OBJECTIVE The incidence of inflammatory bowel disease (IBD) in juvenile idiopathic arthritis (JIA) is higher than in the general pediatric population. However, reports of IBD in the systemic JIA (sJIA) subtype are limited. We sought to characterize sJIA patients diagnosed with IBD and to identify potential contributing risk factors. METHODS Using an internationally distributed survey, we identified 16 sJIA patients who were subsequently diagnosed with IBD (sJIA-IBD cohort). 522 sJIA patients wit...
#2H Laura AaltonenH-Index: 2
Last. Thomas MandlH-Index: 19
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OBJECTIVE To assess pulmonary function and Chronic Obstructive Pulmonary Disease (COPD) development over time in patients with primary Sjogren's Syndrome (pSS) and the association between pulmonary function, radiographic findings, respiratory symptoms and clinical features of pSS, taking cigarette consumption into account. METHODS Forty patients with pSS (mean age 66 yrs, range 42-81 yrs, 39 women), previously participating in a cross-sectional study on pulmonary involvement in pSS, were re-asse...
#1Matthew S. HarkeyH-Index: 11
#2Kate L. LapaneH-Index: 54
Last. Jeffrey B. DribanH-Index: 24
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OBJECTIVE To determine if a one-year change in walking speed is associated with receiving an incident knee replacement during the following year in adults with and at risk for knee osteoarthritis (OA). METHODS Using data from the Osteoarthritis Initiative, we determined a one-year change in 20- meter walk speed from three observation periods (i.e., 0-12, 12-24, and 24-36 month). We operationally defined one-year change in walking speed as either: 1) decline: 0.1 m/s change. Incident knee replace...
#1Ryan T. Lewinson (Alberta Children's Hospital)
#2Vimal H. Prajapati (Alberta Children's Hospital)
Last. Nadia Luca (Alberta Children's Hospital)H-Index: 8
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Brain magnetic resonance imaging (MRI) findings in craniofacial morphea including en coup de sabre (ECDS) localized scleroderma and Parry-Romberg syndrome (PRS; progressive facial hemiatrophy) are not unusual1, but the relevance of rare abnormalities is unknown. We report 2 cases in which distant cerebellar lesions on brain MRI occurred with varying clinical neurologic manifestations.
#1Yiming LuoH-Index: 1
#2Jiehui XuH-Index: 1
Last. Bella MehtaH-Index: 4
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OBJECTIVE Cardiovascular diseases are serious comorbidities in patients with granulomatosis with polyangiitis (GPA). In a sample of patients hospitalized for GPA, we sought to examine trends in the burden of coronary artery disease (CAD) and its two serious manifestations, acute myocardial infraction (AMI) and heart failure (HF). METHODS We used the National Inpatient Sample to conduct a retrospective cross-sectional analysis. Our sample consisted of hospitalizations for GPA between 2005 and 201...
OBJECTIVE Since insulin resistance (IR) is highly prevalent in patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), we aimed to determine whether differences in IR between the two conditions exist. METHODS Cross-sectional study that encompassed 413 non-diabetic subjects, 186 SLE and 227 RA. Glucose, insulin and C-peptide serum levels, as well as IR by the homeostatic model assessment (HOMA2) were studied. A multivariable regression analysis was performed to evaluate th...
Top fields of study
Physical therapy
Rheumatoid arthritis
Diabetes mellitus