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PLOS Neglected Tropical Diseases
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#1Jessica Pereira (UFRJ: Federal University of Rio de Janeiro)H-Index: 3
#2Calebe Diogo (UFRJ: Federal University of Rio de Janeiro)
Last.Adriana Gioda (PUC-Rio: Pontifical Catholic University of Rio de Janeiro)H-Index: 19
view all 14 authors...
Follicular atresia is the mechanism by which the oocyte contents are degraded during oogenesis in response to stress conditions, allowing the energetic resources stored in the developing oocytes to be reallocated to optimize female fitness. Autophagy is a conserved intracellular degradation pathway where double-membrane vesicles are formed around target organelles leading to their degradation after lysosome fusion. The autophagy-related protein 8 (ATG8) is conjugated to the autophagic membrane a...
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We undertook the first study systematically evaluating the risk of Anisakis-sensitization in Croatian fish-processing workers and potential genetic susceptibility to anisakiasis. Anti-Anisakis IgE seroprevalence and risk factors for 600 employees of Croatian fish processing facilities and 466 blood donor controls, were assessed by indirect ELISA targeted with: recombinant Ani s 1 and Ani s 7 allergens, an Anisakis crude extract, the commercial ImmunoCAP kit, and questionnaires. Genetic susceptib...
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#1Alexandra Ehrens (University Hospital Bonn)H-Index: 4
Last.Stephen A. Ward (LSTM: Liverpool School of Tropical Medicine)H-Index: 53
view all 18 authors...
The elimination of filarial diseases such as onchocerciasis and lymphatic filariasis is hampered by the lack of a macrofilaricidal–adult worm killing–drug. In the present study, we tested the in vivo efficacy of AN11251, a boron-pleuromutilin that targets endosymbiotic Wolbachia bacteria from filarial nematodes and compared its efficacy to doxycycline and rifampicin. Doxycycline and rifampicin were previously shown to deplete Wolbachia endosymbionts leading to a permanent sterilization of the fe...
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#1Andrea Kuemmerle (University of Basel)H-Index: 2
#2Caecilia Schmid (University of Basel)H-Index: 8
Last.Mays KisalaH-Index: 1
view all 11 authors...
Background Nifurtimox eflornithine combination therapy (NECT) to treat human African trypanosomiasis (HAT), commonly called sleeping sickness, was added to the World Health Organisation’s (WHO) Essential Medicines List in 2009 and to the Paediatric List in 2012. NECT was further tested and documented in a phase IIIb clinical trial in the Democratic Republic of Congo (DRC) assessing the safety, effectiveness, and feasibility of implementation under field conditions (NECT-FIELD study). This trial ...
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#1Daria Kokova (LUMC: Leiden University Medical Center)H-Index: 2
#2Aswin Verhoeven (LEI: Leiden University)H-Index: 1
Last.Oleg A. Mayboroda (LEI: Leiden University)H-Index: 5
view all 7 authors...
Background Opisthorchiasis is a hepatobiliary disease caused by flukes of the trematode family Opisthorchiidae. Opisthorchiasis can lead to severe hepatobiliary morbidity and is classified as a carcinogenic agent. Here we investigate the time-resolved metabolic response to Opisthorchis felineus infection in an animal model. Methodology Thirty golden hamsters were divided in three groups: severe infection (50 metacercariae/hamster), mild infection (15 metacercariae/hamster) and uninfected (vehicl...
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#1S. Subramanian (ICMR: Indian Council of Medical Research)H-Index: 12
#2Purushothaman Jambulingam (ICMR: Indian Council of Medical Research)H-Index: 16
Last.Hari Kishan K Raju (ICMR: Indian Council of Medical Research)H-Index: 1
view all 10 authors...
Background Lymphatic filariasis (LF) is targeted for elimination by the year 2020. As of 2017, 67 of the 72 endemic countries have implemented annual Mass Drug Administration (MDA) for interrupting LF transmission. Transmission Assessment Survey (TAS) is the recommended protocol to evaluate the impact of MDA and to decide when to stop MDA in an Evaluation Unit (EU, population ≤2 million). As the human infection levels go down with repeated MDA rounds, it becomes a challenge to select the appropr...
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#1Judith E. Pekelharing (MSF: Médecins Sans Frontières)
#2Francis Gatluak (MSF: Médecins Sans Frontières)H-Index: 3
Last.Koert Ritmeijer (MSF: Médecins Sans Frontières)H-Index: 24
view all 6 authors...
Introduction Visceral leishmaniasis (VL) is endemic in South Sudan, where outbreaks occur frequently. Because of changes in the immune system during pregnancy, pregnant women are considered particularly vulnerable for developing complications of VL disease, including opportunistic infections. There is limited evidence available about clinical aspects and treatment outcomes of VL in pregnancy. We describe characteristics, maternal and pregnancy outcomes from a cohort of pregnant women with VL. Me...
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#1Heidi Walkden (Griffith University)H-Index: 1
#2Ali Delbaz (Griffith University)
Last.Johana Tello Velasquez (Trinity College, Dublin)
view all 12 authors...
The infectious disease melioidosis is caused by the bacterium Burkholderia pseudomallei. Melioidosis is characterised by high mortality and morbidity and can involve the central nervous system (CNS). We have previously discovered that B. pseudomallei can infect the CNS via the olfactory and trigeminal nerves in mice. We have shown that the nerve path is dependent on mouse strain, with outbred mice showing resistance to olfactory nerve infection. Damage to the nasal epithelium by environmental fa...
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#1Gerardo Acosta-Jamett (Austral University of Chile)H-Index: 12
#2Constanza Martínez-Valdebenito (UC: Pontifical Catholic University of Chile)H-Index: 7
Last.Katia Abarca V. (UC: Pontifical Catholic University of Chile)H-Index: 17
view all 8 authors...
Background Scrub typhus is an emerging vector-borne zoonosis, caused by Orientia spp. and transmitted by larvae of trombiculid mites, called chiggers. It mainly occurs within a region of the Asia-Pacific called the tsutsugamushi triangle, where rodents are known as the most relevant hosts for the trombiculid vector. However, the reservoir(s) and vector(s) of the scrub typhus outside Asia-Pacific are unknown. The disease has recently been discovered on and is considered endemic for Chiloe Island ...
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#1Elise Farley (UCT: University of Cape Town)H-Index: 1
#2Annick Lenglet (Radboud University Nijmegen)H-Index: 7
Last.Beverley Stringer (MSF: Médecins Sans Frontières)H-Index: 3
view all 9 authors...
Background Noma is an orofacial gangrene that rapidly disintegrates the tissues of the face. Little is known about noma, as most patients live in underserved and inaccessible regions. We aimed to assess the descriptive language used and beliefs around noma, at the Noma Children’s Hospital in Sokoto, Nigeria. Findings will be used to inform prevention programs. Methods Five focus group discussions (FGD) were held with caretakers of patients with noma who were admitted to the hospital at the time ...
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