Biochimica et Biophysica Acta
Papers 115001
1 page of 11.5k pages (115k results)
#1Ivonne Olmedo (University of Chile)H-Index: 11
#2Gonzalo Pino (University of Chile)
Last.Gina Sánchez (University of Chile)H-Index: 18
view all 10 authors...
Abstract Cardiomyocyte loss is the main cause of myocardial dysfunction following an ischemia-reperfusion (IR) injury. Mitochondrial dysfunction and altered mitochondrial network dynamics play central roles in cardiomyocyte death. Proteasome inhibition is cardioprotective in the setting of IR; however, the mechanisms underlying this protection are not well-understood. Several proteins that regulate mitochondrial dynamics and energy metabolism, including Mitofusin-2 (Mfn2), are degraded by the pr...
#1Thayna Sisnande (UFRJ: Federal University of Rio de Janeiro)H-Index: 2
#2Cleverton Kleiton Freitas de Lima (UFRJ: Federal University of Rio de Janeiro)H-Index: 7
Last.Luís Maurício T. R. Lima (UFRJ: Federal University of Rio de Janeiro)H-Index: 21
view all 8 authors...
Abstract Zinc is a key component of several proteins, interacting with the pancreatic hormones insulin and amylin. The role of zinc in insulin oligomerization and crystallinity is well established, although the effects of dietary zinc restriction on both energetic metabolism and β-pancreatic hormonemia and morphology remain unexplored. Here we report the effects of dietary zinc restriction on the endocrine pancreas and metabolic phenotype of mice. Nontransgenic male Swiss mice were fed a low-zin...
#1Li Kong (LEI: Leiden University)H-Index: 2
#2Edgar Dawkins (LMU: Ludwig Maximilian University of Munich)
Last.Alexander Kros (LEI: Leiden University)H-Index: 35
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Abstract The biophysical properties and biological functions of membranes are highly dependent on lipid composition. Supplementing cellular membranes with very long chain fatty acids (vlcFAs) is notoriously difficult given the extreme insolubility of vlcFAs in aqueous solution. Herein, we report a solvent-free, photochemical approach to enrich target membranes with vlcFA. To prevent aggregation of vlcFA, we created light-sensitive micelles composed exclusively of poly-ethylene-glycol-nervonic ac...
#1María C. Amezcua Vesely (National University of Cordoba)H-Index: 5
#2Constanza Rodriguez (National University of Cordoba)H-Index: 2
Last.Eva V. Acosta Rodríguez (National University of Cordoba)H-Index: 6
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Abstract Host resistance during infection with Trypanosoma cruzi, and other protozoans, is dependent on a balanced immune response. Robust immunity against these pathogens requires of the concerted action of many innate and adaptive cell populations including macrophages, neutrophils, dendritic cells, CD4+, and CD8+ T cells and B cells among others. Indeed, during most protozoan infections only a balanced production of inflammatory (TH1) and anti-inflammatory (TH2/regulatory) cytokines will allo...
#1Ondřej Peterka (UPA: University of Pardubice)
#2Robert Jirásko (UPA: University of Pardubice)H-Index: 20
Last.Michal Holčapek (UPA: University of Pardubice)H-Index: 36
view all 10 authors...
Abstract Ultrahigh-performance supercritical fluid chromatography - mass spectrometry (UHPSFC/MS), ultrahigh-performance liquid chromatography - mass spectrometry (UHPLC/MS), and matrix-assisted laser desorption/ionization (MALDI) - MS techniques were used for the lipidomic characterization of exosomes isolated from human plasma. The high-throughput methods UHPSFC/MS and UHPLC/MS using a silica-based column containing sub-2 μm particles enabled the lipid class separation and the quantitation bas...
#1Cinzia Bragato (University of Milano-Bicocca)H-Index: 7
#2Silvia CarraH-Index: 8
Last.Marina MoraH-Index: 40
view all 11 authors...
Abstract Pompe disease (PD) is an autosomal recessive muscular disorder caused by deficiency of the glycogen hydrolytic enzyme acid α-glucosidase (GAA). The enzyme replacement therapy, currently the only available therapy for PD patients, is efficacious in improving cardiomyopathy in the infantile form, but not equally effective in the late onset cases with involvement of skeletal muscle. Correction of the skeletal muscle phenotype has indeed been challenging, probably due to concomitant dysfunc...
Abstract Progression of acute pancreatitis (AP) into a severe form usually results in a life-threatening condition with multiple organ dysfunction, and in particular acute lung injury (ALI), often contributes to the majority of AP-associated deaths. Increasing evidence has shown that uncontrolled activation of the immune system with rapid production of inflammatory cytokines play a dominant role in this process. As an intracellular inflammatory signaling platform, the NOD-like receptor protein 3...
#1M. V. Dubinin (RAS: Russian Academy of Sciences)H-Index: 3
#2Eugeny Yu. Talanov (RAS: Russian Academy of Sciences)H-Index: 1
Last.Konstantin N. Belosludtsev (RAS: Russian Academy of Sciences)H-Index: 9
view all 7 authors...
Abstract Duchenne muscular dystrophy (DMD) is characterized by a pronounced and progressive degradation of the structure of skeletal muscles, which decreases their strength and lowers endurance of the organism. At muscular dystrophy, mitochondria are known to undergo significant functional changes, which is manifested in a decreased efficiency of oxidative phosphorylation and impaired energy metabolism of the cell. It is believed that the DMD-induced functional changes of mitochondria are mainly...
#1Chitra SubramanianH-Index: 16
#2Chitra Subramanian (St. Jude Children's Research Hospital)H-Index: 8
Last.Suzanne JackowskiH-Index: 58
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Abstract Pantothenate kinase (PanK) is the first enzyme in the coenzyme A (CoA) biosynthetic pathway. The differential expression of the four-active mammalian PanK isoforms regulates CoA levels in different tissues and PANK2 mutations lead to P antothenate K inase A ssociated N eurodegeneration (PKAN). The molecular mechanisms that potentially underlie PKAN pathophysiology are investigated in a mouse model of CoA deficiency in the central nervous system (CNS). Both PanK1 and PanK2 contribute to ...
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Molecular biology