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Biochimica et Biophysica Acta
IF
3.79
Papers
113914
Papers 114198
1 page of 11.4k pages (114k results)
Newest
Abstract Multicellular Tumor Spheroids culture (MCTS) is an in vitro model mimicking the characteristics of the tumor microenvironment, such as hypoxia and acidosis, resulting in the presence of both proliferating and quiescent cell populations. lncRNA's is a novel group of regulatory molecules that participates in the acquisition of tumorigenic phenotypes. In the present work we evaluated the oncogenic association of an uncharacterized lncRNA (lncRNA-HAL) in the tumorigenic phenotype induced by...
#1Sherry See Wai Leung (SFU: Simon Fraser University)
#2Jonathan R. Brewer (University of Southern Denmark)H-Index: 19
Last.Jenifer Thewalt (SFU: Simon Fraser University)H-Index: 19
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Abstract Two dimensional phase separation in lipid membranes and cell membranes is of interest to biology because of the idea of membrane rafts — compositionally heterogeneous liquid crystal domains with cellular functions. Few quantitative tools exist for characterizing and differentiating coexisting phases on a molecular scale. Lipid acyl chain order can be measured directly using deuterium nuclear magnetic resonance spectroscopy (2H NMR), or indirectly using fluorescence microscopy along with...
#1Fernanda Costa Brandão Berti (UFPR: Federal University of Paraná)H-Index: 1
#2Amanda Salviano-Silva (UFPR: Federal University of Paraná)H-Index: 4
Last.Danielle Malheiros (UFPR: Federal University of Paraná)H-Index: 5
view all 6 authors...
Abstract Despite Human Papillomavirus (HPV) essential role in cervical carcinogenesis, other factors are required for cancer establishment, like miRNAs. Such molecules present a complex biogenesis, being diversely distributed across tissues and biological fluids, as cell-free miRNAs or miRNAs present in extracellular vesicles (EV). After HPV infection, an interplay between HPV and the miRNA network occurs in cervical cells. As the virus persists and cellular transformation occurs, specific patte...
#1Koki AbeH-Index: 2
#2Toshiyuki YanoH-Index: 18
Last.Yukishige KimuraH-Index: 5
view all 10 authors...
Abstract Accumulating evidence indicates that necroptosis contributes to cardiovascular diseases. We recently reported suppression of autophagy by necroptotic signals in cardiomyocytes and protective action of rapamycin. Here we examined the mechanism by which mTORC1 inhibition protects cardiomyocytes from necroptosis. Necroptosis of H9c2 cells was induced by treatment with tumor necrotic factor-α (TNF) and z-VAD-fmk (zVAD), and the extent of necroptosis was determined as the level of LDH releas...
Abstract Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity...
#1Daria N. Shalaeva (MSU: Moscow State University)H-Index: 4
#2Dmitry A. Cherepanov (MSU: Moscow State University)H-Index: 24
Last.Armen Y. Mulkidjanian (MSU: Moscow State University)H-Index: 31
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Abstract The human genome contains about 700 genes of G protein-coupled receptors (GPCRs) of class A; these seven-helical membrane proteins are the targets of almost half of all known drugs. In the middle of the helix bundle, crystal structures reveal a highly conserved sodium-binding site, which is connected with the extracellular side by a water-filled tunnel. The binding site contains a sodium ion in those GPCRs that are crystallized in their inactive conformations but does not in those GPCRs...
#1Arianna F. Anzmann (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 1
#2Sneha M. Pinto (Manipal University)H-Index: 18
Last.Hilary J. Vernon (ICSCI: Kennedy Krieger Institute)H-Index: 10
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Abstract Background Methylmalonic acidemia (MMA) and propionic acidemia (PA) are related disorders of mitochondrial propionate metabolism, caused by defects in methylmalonyl-CoA mutase (MUT) and propionyl-CoA carboxylase (PCC), respectively. These biochemical defects lead to a complex cascade of downstream metabolic abnormalities, and identification of these abnormal pathways has important implications for understanding disease pathophysiology. Using a multi-omics approach in cellular models of ...
#1Yi-Yun Cheng (NTHU: National Tsing Hua University)H-Index: 1
#2Yun-Fang Huang (NTHU: National Tsing Hua University)
Last.Ping-Chiang Lyu (NTHU: National Tsing Hua University)H-Index: 35
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Abstract The intracellular transport of lipophilic cargoes is a highly dynamic process. In eukaryotic cells, the uptake and release of long-chain fatty acids (LCFAs) are executed by fatty-acid binding proteins. However, how these carriers control the directionality of cargo trafficking remains unclear. Here, we revealed that the unliganded archetypal Drosophila brain-type fatty acid-binding protein (dFABP) possesses a stronger binding affinity than its liganded counterpart for empty nanodiscs (N...
#1Galina M. Viryasova (MSU: Moscow State University)H-Index: 3
#2Victor V. Tatarskiy (RAS: Russian Academy of Sciences)H-Index: 5
Last.N. V. Soshnikova (RAS: Russian Academy of Sciences)H-Index: 3
view all 7 authors...
Abstract The myeloid precursor cell differentiation requires an extensive chromatin remodeling. We show that the level of the PBAF chromatin remodeling complex decreases following the start of differentiation of myeloid precursors, becoming very low in the terminally differentiated peripheral blood (PB) neutrophils where it co-localizes with Pol II on the transcriptionally active chromatin. Previously, we have shown that the PHF10 subunit of the PBAF signature module has four isoforms, two of th...
#1Shohreh Azadi (Macquarie University)
#2Hamidreza Abolkheyr (UTS: University of Technology, Sydney)
Last.Majid Ebrahimi Warkiani (UTS: University of Technology, Sydney)H-Index: 21
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Abstract Expression of programmed death-ligand 1 (PD-L1) in cancer cells plays an important role in cancer-immune cell interaction. The emerging evidence suggests regulation of PD-L1 expression by several tumor microenvironmental cues. However, the association of PD-L1 expression with chemical and mechanical features of the tumor microenvironment, specifically epidermal growth factor receptor (EGFR) signaling and matrix stiffness, remains elusive. Herein, we determine whether EGFR targeting and ...
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