Biochimica et Biophysica Acta
Papers 114407
1 page of 11.4k pages (114k results)
#1JungYeon Kim (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
#2Bonne M. Thompson (UTSW: University of Texas Southwestern Medical Center)H-Index: 11
Last.Jin Ye (UTSW: University of Texas Southwestern Medical Center)H-Index: 24
view all 6 authors...
Abstract Clear cell renal cell carcinoma (ccRCC), which accounts for the majority of kidney cancer, is known to accumulate excess cholesterol. However, the mechanism and functional significance of the lipid accumulation for development of the cancer remains obscure. In this study, we analyzed 42 primary ccRCC samples, and determined that cholesterol levels of ~ 70% of the tumors were at least two-fold higher than that of benign kidney tissues. Compared to tumors without cholesterol accumulation,...
Abstract Multicellular Tumor Spheroids culture (MCTS) is an in vitro model mimicking the characteristics of the tumor microenvironment, such as hypoxia and acidosis, resulting in the presence of both proliferating and quiescent cell populations. lncRNA's is a novel group of regulatory molecules that participates in the acquisition of tumorigenic phenotypes. In the present work we evaluated the oncogenic association of an uncharacterized lncRNA (lncRNA-HAL) in the tumorigenic phenotype induced by...
#1Jessica Schira-Heinen (HHU: University of Düsseldorf)
#2Leonie Grube (HHU: University of Düsseldorf)H-Index: 1
Last.Kai Stühler (HHU: University of Düsseldorf)H-Index: 30
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Abstract Proteins are released from cells by different secretory pathways. The secretory pathway via the ER-Golgi route - realized by a signal sequence - is referred to as “classical secretion”. In contrast, alternative secretory pathways were summarized as “unconventional protein secretion”. Until now, unconventional protein secretion was lacking attention due to the absence of detailed mechanistic insight and limited experimental access. However, there is a growing number of experimental data ...
#1Omar Najim (University of Antwerp)H-Index: 1
#2Sofie Seghers (University of Antwerp)
Last.Wiebren A.A. Tjalma (University of Antwerp)H-Index: 27
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Abstract Background Breast cancer has, due to its high incidence, the highest mortality of cancer in women. The most common molecular type of breast cancer is the luminal subtype, which expresses estrogen and progesterone receptors and is typically treated with surgery and adjuvant endocrine therapy (ET). Estrogen receptor alpha (ERα), encoded by the estrogen receptor-1 (ESR1) gene, is expressed in approximately 70% of all breast cancers, and ET represents a major treatment modality in ERα-posit...
#1Imee M.A. del Mundo (University of Texas at Austin)H-Index: 3
#2Karen M. Vasquez (University of Texas at Austin)H-Index: 39
Last.Guliang Wang (University of Texas at Austin)H-Index: 18
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Abstract Genome integrity is essential for proper cell function such that genetic instability can result in cellular dysfunction and disease. Mutations in the human genome are not random, and occur more frequently at “hotspot” regions that often co-localize with sequences that have the capacity to adopt alternative (i.e. non B) DNA structures. Non-B DNA-forming sequences are mutagenic, can stimulate the formation of DNA double-strand breaks, and are highly enriched at mutation hotspots in human ...
#1Sherry See Wai Leung (SFU: Simon Fraser University)
#2Jonathan R. Brewer (University of Southern Denmark)H-Index: 20
Last.Jenifer Thewalt (SFU: Simon Fraser University)H-Index: 20
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Abstract Two dimensional phase separation in lipid membranes and cell membranes is of interest to biology because of the idea of membrane rafts — compositionally heterogeneous liquid crystal domains with cellular functions. Few quantitative tools exist for characterizing and differentiating coexisting phases on a molecular scale. Lipid acyl chain order can be measured directly using deuterium nuclear magnetic resonance spectroscopy (2H NMR), or indirectly using fluorescence microscopy along with...
#1Guillermo Hugo Jimenez-Aleman (CSIC: Spanish National Research Council)H-Index: 7
#2Marilia Almeida-Trapp (MPG: Max Planck Society)H-Index: 1
Last.Roberto Solano (CSIC: Spanish National Research Council)H-Index: 44
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Abstract Jasmonates are fatty acid derivatives that control several plant processes including growth, development and defense. Despite the chemical diversity of jasmonates, only jasmonoyl-L-isoleucine (JA-Ile) has been clearly characterized as the endogenous ligand of the jasmonate co-receptors (COI1-JAZs) in higher plants. Currently, it is accepted that ω-hydroxylation of JA-Ile leads to inactivation of the molecule. This study shows that ω-hydroxylated JA-Ile (12-OH-JA-Ile) retains bioactivity...
#1Fernanda Costa Brandão Berti (UFPR: Federal University of Paraná)H-Index: 1
#2Amanda Salviano-Silva (UFPR: Federal University of Paraná)H-Index: 4
Last.Danielle Malheiros (UFPR: Federal University of Paraná)H-Index: 5
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Abstract Despite the essential role of Human Papillomavirus (HPV) in cervical carcinogenesis, other factors are required for cancer establishment, like miRNAs. Such molecules present a complex biogenesis, being diversely distributed across tissues and biological fluids, as cell-free miRNAs or miRNAs present in extracellular vesicles (EV). After HPV infection, an interplay between HPV and the miRNA network occurs in cervical cells. As the virus persists and cellular transformation occurs, specifi...
1 CitationsSource
#1Koki Abe (Sapporo Medical University)H-Index: 3
#2Toshiyuki Yano (Sapporo Medical University)H-Index: 18
Last.Tetsuji Miura (Sapporo Medical University)H-Index: 52
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Abstract Accumulating evidence indicates that necroptosis contributes to cardiovascular diseases. We recently reported suppression of autophagy by necroptotic signals in cardiomyocytes and protective action of rapamycin. Here we examined the mechanism by which mTORC1 inhibition protects cardiomyocytes from necroptosis. Necroptosis of H9c2 cells was induced by treatment with tumor necrotic factor-α (TNF) and z-VAD-fmk (zVAD), and the extent of necroptosis was determined as the level of LDH releas...
#1K. Michael Pollard (Scripps Health)H-Index: 20
#2David M. Cauvi (UCSD: University of California, San Diego)H-Index: 11
Last.Dwight H. Kono (Scripps Health)H-Index: 48
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Abstract Background Human exposure to mercury leads to a variety of pathologies involving numerous organ systems including the immune system. A paucity of epidemiological studies and suitable diagnostic criteria, however, has hampered collection of sufficient data to support a causative role for mercury in autoimmune diseases. Nevertheless, there is evidence that mercury exposure in humans is linked to markers of inflammation and autoimmunity. This is supported by experimental animal model studi...
2 CitationsSource
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Molecular biology