Frontiers of Medicine in China
Papers 915
1 page of 92 pages (915 results)
Published on Sep 11, 2019in Frontiers of Medicine in China
Meng Lv10
Estimated H-index: 10
(PKU: Peking University),
Xiao-Hui Zhang23
Estimated H-index: 23
(PKU: Peking University)
+ 10 AuthorsJing-Zhi Wang14
Estimated H-index: 14
(PKU: Peking University)
Chronic graft-versus-host disease (cGVHD) is a major complication following unmanipulated haploidentical hematopoietic stem cell transplantation (haplo-HSCT). We aimed to identify the risk factors for cGVHD in patients who underwent anti-thymocyte globulin-based haplo-HSCT for acute myeloid leukemia (n = 280). The diagnosis of cGVHD was in accordance with the National Institutes of Health consensus criteria. A total of 169 patients suffered from cGVHD. The patients who had 3 loci mismatched had ...
Published on Sep 7, 2019in Frontiers of Medicine in China
Mengxue Huang , Jingjing Wang (Beijing Jiaotong University)+ 10 AuthorsGuihua Li (Hubei University of Chinese Medicine)
Pediatric cough is a heterogeneous condition in terms of symptoms and the underlying disease mechanisms. Symptom phenotypes hold complicated interactions between each other to form an intricate network structure. This study aims to investigate whether the network structure of pediatric cough symptoms is associated with the prognosis and outcome of patients. A total of 384 cases were derived from the electronic medical records of a highly experienced traditional Chinese medicine (TCM) physician. ...
Published on Sep 7, 2019in Frontiers of Medicine in China
Xiaokun Li (WMU: Wenzhou Medical College)
Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members by acquiring divergent structural elements that enable functional divergence and specification. Heparan sulfate-binding FGFs, which play critical roles in embryonic development and adult tissue remodeling homeostasis, adapt to an autocrine/paracrine mode of action to promote cell proliferation and population growth. By...
Published on Aug 29, 2019in Frontiers of Medicine in China
Rui Zhou , Yuanshu Liu + 1 AuthorsXitong Dang10
Estimated H-index: 10
Esophageal cancer-related gene-4 (Ecrg4) is cloned from the normal epithelium of the esophagus. It is constitutively expressed in quiescent epithelial cells and downregulated during tumorigenesis, and Ecrg4 expression levels are inversely correlated with the malignant phenotype of tumor cells, validating that Ecrg4 is a real tumor suppressor gene. Unlike other tumor suppressor genes that usually encode membrane or intracellular proteins, Ecrg4 encodes a 148-amino acid pre-pro-peptide that is tet...
Published on 2019in Frontiers of Medicine in China
Xiaoran Sun1
Estimated H-index: 1
(PKU: Peking University),
Jiagui Song3
Estimated H-index: 3
(PKU: Peking University)
+ 3 AuthorsHongquan Zhang19
Estimated H-index: 19
(PKU: Peking University)
Pancreatic ductal adenocarcinoma (PDAC) is the ninth most common human malignancy and the sixth leading cause of cancer-related death in China. AcK27-HOXB9 is a newly identified HOXB9 post-transcriptional modification that can predict the outcome in lung adenocarcinoma and colon cancer well. However, the role of AcK27-HOXB9 in PDAC is unclear. The present study aims to investigate the differential diagnostic role of patients with AcK27-HOXB9 PDAC. Tissue microarrays consisting of 162 pancreatic ...
Published on Mar 2, 2019in Frontiers of Medicine in China
Yumeng Wang (Fudan University), Guiling Li (Fudan University)
Cervical cancer (CC) is the fourth most commonly diagnosed female malignancy and a leading cause of cancer-related mortality worldwide, especially in developing countries. Despite the use of advanced screening and preventive vaccines, more than half of all CC cases are diagnosed at advanced stages, when therapeutic options are extremely limited and side effects are severe. Given these circumstances, new and effective treatments are needed. In recent years, exciting progress has been made in immu...
Published on Apr 24, 2019in Frontiers of Medicine in China
Jun-Jun Jia6
Estimated H-index: 6
Xinyao Tian + 6 AuthorsShusen Zheng41
Estimated H-index: 41
Understanding the effect of immunosuppressive agents on intestinal microbiota is important to reduce the mortality and morbidity from orthotopic liver transplantation (OLT). We investigated the relationship between the commonly used immunosuppressive agent cyclosporine A (CSA) and the intestinal microbial variation in an OLT model. The rat samples were divided as follows: (1) N group (normal control); (2) I group (isograft LT, Brown Norway [BN] rat to BN); (3) R group (allograft LT, Lewis to BN ...
Published on Apr 4, 2019in Frontiers of Medicine in China
Li-Juan Hu1
Estimated H-index: 1
(PKU: Peking University),
Lijuan Hu (PKU: Peking University)+ 9 AuthorsKai-Yan Liu29
Estimated H-index: 29
(PKU: Peking University)
We aimed to identify the effect of positive stool cultures (PSCs) on the clinical outcomes of patients undergoing haploidentical hematopoietic stem cell transplantation (haplo-HSCT) (n = 332). PSCs were observed in 61 patients (PSC group, 18.4%). Enterobacteriaceae in stool specimens was associated with a higher risk of bloodstream infection, and Candida in stool specimens was related to a higher risk of platelet engraftment failure. The cumulative incidence of infection-related mortality 1 year...
Published on Sep 7, 2018in Frontiers of Medicine in China
Dahai Zhao1
Estimated H-index: 1
(SJTU: Shanghai Jiao Tong University),
Zhiruo Zhang2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University)
Studies examining the trends in public trust in physicians have provided a considerable amount of valuable policy implications for policymakers compared with cross-sectional studies on this topic in many countries. This study investigated changes in public trust in physicians in China based on two cross-sectional national surveys conducted in 2011 and 2016 and identified the determinants of these changes. The results indicated 83.4% of respondents in 2011 reported trust or strong trust in physic...