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International Journal of Infectious Diseases
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#1Dankmar Böhning (University of Southampton)H-Index: 31
#2Irene RocchettiH-Index: 4
Last. Heinz Holling (WWU: University of Münster)H-Index: 24
view all 4 authors...
OBJECTIVES: A major open question, affecting the decisions of policy makers, is the estimation of the true number of Covid-19 infections. Most of them are undetected, because of a large number of asymptomatic cases. We provide an efficient, easy to compute and robust lower bound estimator for the number of undetected cases. METHODS: A modified version of the Chao estimator is proposed, based on the cumulative time-series distributions of cases and deaths. Heterogeneity has been addressed by assu...
4 CitationsSource
#1Chao-xin Wang (Fujian Medical University)H-Index: 1
#2Zida Huang (Fujian Medical University)H-Index: 3
Last. Huan HuH-Index: 2
view all 13 authors...
Abstract Objectives Pathogen identification is crucial for the diagnosis and management of periprosthetic joint infection (PJI). Although culturing methods are the foundation of pathogen detection in PJI, false negative results often occur. Oxford nanopore sequencing (ONS) is a promising alternative to detect pathogens and provide information on their antimicrobial resistance (AMR) profiles without culturing. Methods To evaluate the capability of metagenomic ONS (mONS) in detecting pathogens fro...
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#1Osman Kilic (Istanbul Medeniyet University)H-Index: 1
#2Mahmut Tayyar Kalcioglu (Istanbul Medeniyet University)H-Index: 4
Last. Ferihan Cetın (Istanbul Medeniyet University)
view all 7 authors...
Abstract Objective The aim of this study is to investigate the presence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) in patients presenting with only sudden sensorineural hearing loss (SSNHL) during the pandemic. Methods The study included 5 male patients who presented with the sole complaint of unilateral SSNHL to the otolaryngology outpatient clinic between April 3 and April 12, 2020. The patients were referred to the infectious diseases clinic to be evaluated for SARS-CoV-2...
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#1Fang Guo (Boston Children's Hospital)
#2Lei Kang (Boston Children's Hospital)
Last. Meixian Xu (Boston Children's Hospital)
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Background: Visceral leishmaniasis-related hemophagocytic lymphohistiocytosis (VL-HLH) is a secondary hemophagocytic syndrome, which can be life-threatening, caused by leishmania and transmitted by infected sandflies. Rapid and accurate identification of leishmania is crucial for clinical strategies. Case report: Here, we report an infantile infection in a non-epidemic area of China. The infant was a 9.5-month-old girl with fever, pancytopenia and hepatosplenomegaly, which meet the HLH-2004 stan...
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#1Mohammad Akhoundi (Nord University)
#2Anthony Marteau (Nord University)
Last. Arezki Izri (AMU: Aix-Marseille University)H-Index: 6
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#1Sandra De Meyer (Janssen Pharmaceutica)H-Index: 23
#2Denisa Bojkova (Goethe University Frankfurt)H-Index: 2
Last. Sandra Ciesek (Goethe University Frankfurt)H-Index: 22
view all 8 authors...
Abstract Objectives Given the high need and the absence of specific antivirals for treatment of COVID-19 (the disease caused by severe acute respiratory syndrome-associated coronavirus-2 [SARS-CoV-2]), human immunodeficiency virus (HIV) protease inhibitors are being considered as therapeutic alternatives. Methods Prezcobix/Rezolsta is a fixed-dose combination of 800 mg of the HIV protease inhibitor darunavir (DRV) and 150 mg cobicistat, a CYP3A4 inhibitor, which is indicated in combination with ...
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#1Mengyuan Lyu (Sichuan University)H-Index: 4
Last. Binwu Ying (Sichuan University)H-Index: 16
view all 8 authors...
Abstract Objectives This work aimed to explore the relationship between glycosylated hemoglobin (HbA1c) and the risk of anti-tuberculosis (TB) drug resistance for TB-type 2 diabetes mellitus (T2DM) patients. Methods From March 2014 to June 2019, medical records from multi-centers were searched. Logistic regression analyses were performed. Predictive model for multidrug resistance (MDR) was developed and validated. Calibration and discrimination of the model were assessed. Results Inconsistent re...
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#1Edward K. Maina (Kenya Medical Research Institute)H-Index: 3
#2H. Mureithi (Kenya Medical Research Institute)
Last. Elizabeth A. Bukusi (Kenya Medical Research Institute)H-Index: 44
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Abstract Background Limited data is available on incidences and factors associated with viral rebound following viral suppression among HIV infected individuals taking antiretroviral therapy (ART) in Kenya. Furthermore, the durability of viral suppression among HIV individuals taking ART is unknown. Information on incidences and factors associated with HIV viral load rebounds and durability of viral suppression (undetectable HIV copies in plasma) among HIV infected individuals taking ART will he...
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#1Danilo Buonsenso (UCSC: Catholic University of the Sacred Heart)H-Index: 11
#2Bianca Cinicola (Sapienza University of Rome)H-Index: 1
Last. Francesco IodiceH-Index: 5
view all 5 authors...
Abstract Economical and psychological consequences of the lockdown in low-resource setting in rural Africa are unknown. We drafted a survey in order to address the social impact of COVID-19 lockdown on a rural village in Sierra Leone. The survey developed by the study group and translated in the local language, distributed to the householders of the village on April 13th and responses collected on April 14th, when Sierra Leone was on day 11 of lockdown. The questions aimed to assess in the commu...
1 CitationsSource
#1Li Zhang (CDC: Centers for Disease Control and Prevention)H-Index: 7
#2Chengxiao Yu (Nanjing Medical University)H-Index: 3
Last. Jingxin Li (CDC: Centers for Disease Control and Prevention)H-Index: 19
view all 11 authors...
PURPOSE To explore the molecular genetic mechanisms underlying different responsiveness to Enterovirus 71(EV71) vaccine. METHODS We recruited 10,245 healthy children into a phase 3 clinical trial to evaluate the efficacy of EV71 vaccine in 2012. Fifty subjects from the trial were divided into the potent immune response group (20 subjects) and the ineffective immune response group (30 subjects). Whole-exome sequencing was performed for these 50 samples and we conducted bioinformatics analyses bas...
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