Molecular Oral Microbiology
Papers 390
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#1Yuqing Li (Sichuan University)H-Index: 8
#2Biao Ren (Sichuan University)H-Index: 7
Last. Xuedong Zhou (Sichuan University)H-Index: 35
view all 9 authors...
SARS-CoV-2, a novel emerging coronavirus, has caused severe disease (COVID-19), and rapidly spread worldwide since the beginning of 2020. SARS-CoV-2 mainly spreads by coughing, sneezing, droplet inhalation, and contact. SARS-CoV-2 has been detected in saliva samples, making saliva a potential transmission route for COVID-19. The participants in dental practice confront a particular risk of SARS-CoV-2 infection due to close contact with the patients and potential exposure to saliva-contaminated d...
#1Jintaek Im (SNU: Seoul National University)H-Index: 12
#2Jung Eun Baik (SNU: Seoul National University)H-Index: 14
Last. Seung Hyun Han (SNU: Seoul National University)H-Index: 34
view all 7 authors...
Periodontitis is a chronic inflammatory disease of the gums caused by infection with multispecies oral bacteria. Since the periodontopathic bacteria Porphyromonas gingivalis together with Enterococcus faecalis are frequently detected in patients with a severe form of periodontitis, interactions between their virulence factors might play an important role in progression of the disease. P. gingivalis and E. faecalis possess lipopolysaccharide (Pg.LPS) and lipoteichoic acid (Ef.LTA), respectively, ...
#1Joseph O’Brien (Middlebury College)
#2Alexander Pastora (Middlebury College)
Last. Grace A. Spatafora (Middlebury College)H-Index: 13
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Streptococcus mutans is a colonizer of the human dentition, and under conditions of dysbiosis is the primary causative agent of dental caries. The pathogenic potential of S. mutans depends, in part, on its ability to regulate the transport of metal ions across the plasma membrane to maintain intracellular metal ion homeostasis. Research in our laboratory has focused on the Mn(2+) -specific SloC lipoprotein importer and its regulator encoded by the S. mutans sloR gene. Herein, we used a bioinform...
#1Jonathon L. Baker (JCVI: J. Craig Venter Institute)H-Index: 3
#1J. L. Baker (UR: University of Rochester)H-Index: 6
Last. Robert G. Quivey (UR: University of Rochester)H-Index: 22
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Streptococcus mutans is a major etiologic agent of dental caries, which is the most common chronic infectious disease worldwide. S. mutans is particularly adept at causing caries due to its exceptional capacity to form biofilms and its ability to survive acidic conditions that arrest acid production and growth in many more benign members of the oral microbiota. Two mechanisms utilized by S. mutans to tolerate acid are: modulation of the membrane fatty acid content and utilization of the F1 F0 -A...
#1Saswati Biswas (KU: University of Kansas)H-Index: 9
#2Andrew Keightley (UMKC: University of Missouri–Kansas City)H-Index: 9
Last. Indranil Biswas (KU: University of Kansas)H-Index: 16
view all 3 authors...
Lactobacillus rhamnosus is an important lactic acid bacterium that is predominantly used as a probiotic supplement. This bacterium secretes immunomodulatory and antibacterial peptides that are necessary for the probiotic trait. This organism also occupies diverse ecological niches, such as gastrointestinal tracts and the oral cavity. Several studies have shown that L. rhamnosus is prone to spontaneous genome rearrangement irrespective of the ecological origins. We previously characterized an ora...
#1Dhana G. Gorasia (University of Melbourne)H-Index: 13
#2Michelle D. Glew (University of Melbourne)H-Index: 21
Last. Eric C. Reynolds (University of Melbourne)H-Index: 63
view all 4 authors...
Porphyromonas gingivalis is an anaerobic, Gram-negative human oral pathogen highly associated with chronic periodontitis. P. gingivalis utilises the type IX secretion system (T9SS) to transport many of its virulence factors including the gingipains to the cell surface. The T9SS is comprised of at least 16 proteins and the involvement of these 16 proteins in the T9SS has been verified by creating gene deletion mutants in P. gingivalis. These T9SS mutants are regularly utilised to understand how t...
1 CitationsSource
#1Eric Krueger (Lehigh University)H-Index: 7
#2Angela C. Brown (Lehigh University)H-Index: 10
Aggregatibacter actinomycetemcomitans is a Gram-negative bacterium associated with localized aggressive periodontitis, as well as other systemic diseases. This organism produces a number of virulence factors, all of which provide some advantage to the bacterium. Several studies have demonstrated that clinical isolates from diseased patients, particularly those of African descent, frequently belong to specific clones of A. actinomycetemcomitans that produce significantly higher amounts of a prote...
#1Tao Gong (Sichuan University)H-Index: 1
#2Jumei Zeng (Sichuan University)
Last. Yuqing Li (Sichuan University)H-Index: 8
view all 5 authors...
The clustered regularly interspaced short palindromic repeats with CRISPR-associated proteins (CRISPR-Cas) system, found in bacteria and archaea, provides sequence-based adaptive immunity against mobile genetic elements, including phages and plasmids. The oral cavity contains approximately 700 prokaryote species harboring known CRISPR-Cas systems, including type I, type II, type III, type V, and type VI, and unidentified CRISPR-Cas systems. There is increasing evidence to suggest that different ...
#1Richard Bauer (University of Ulm)H-Index: 2
#2Nathalie Neffgen (University of Ulm)
Last. Barbara Spellerberg (University of Ulm)H-Index: 15
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Streptococcus anginosus is a commensal of the oral mucosa that can cause severe invasive infections. A considerable proportion of Streptococcus anginosus strains are ss-hemolytic due to the presence of an SLS-like gene cluster. However, the majority of strains do not display ss-hemolysis. To investigate ss-hemolysin heterogeneity in S. anginosus, we determined the presence of sag genes and correlated it with the presence of CRISPR/Cas genes in a collection of ss-hemolytic and non-ss-hemolytic st...
#1Mohammad Roky (University of Louisville)
#2John O. Trent (University of Louisville)H-Index: 45
Last. Donald R. Demuth (University of Louisville)H-Index: 26
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Porphyromonas gingivalis is associated with chronic periodontitis and may initially colonize the oral cavity by adhering to streptococci. Adhesion to streptococci is driven by interaction of the minor fimbrial antigen (Mfa1) with streptococcal antigen I/II. We identified the region of antigen I/II required for this interaction and developed small molecule mimetics that inhibited P. gingivalis adherence. However, the functional motifs of Mfa1 involved in the interaction with antigen I/II remain u...
Top fields of study
Molecular biology
Porphyromonas gingivalis