Carbohydrate Research
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Abstract N,N,N-trimethyl chitosan (TMC), quaternized hydrophilic derivative of chitosan, has been projected to have wide applications in the pharmaceutical industry owing to its improved solubility at physiological conditions. However, the conventional synthesis of TMC involves toxic organic agents, which complicates its use for biological applications. Moreover, these reactions result into unwanted O-methylation and scission of the parent polymer. In the present study we have addressed these li...
#1Tatsuya Sato (Kobe University)
#2Shunichi Mori (Kobe University)
Last. Takashi Nishino (Kobe University)H-Index: 34
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Abstract Cellulose nanofiber (CNF) materials have received much attention as sustainable “green” materials with high mechanical properties. Their application in oil absorption and enzymatic lipolysis makes them further attractive from the perspective of environmental issues including marine pollution preservation. Herein, we prepared CNF cryogels with various surface properties, evaluated their capacities as oil absorbents and applied them as lipase-lipolysis scaffolds. Their obtained cryogels c...
#1Birgitte Zeuner (DTU: Technical University of Denmark)H-Index: 12
#2Anne S. Meyer (DTU: Technical University of Denmark)H-Index: 64
Abstract Human milk oligosaccharides (HMOs) are a family of structurally distinct carbohydrate oligomers present in human milk. HMOs protect breastfed babies against infection and promote the development of infant health and cognition. In the gut, fucosylated HMOs in particular function as decoy receptors that intercept epithelial attachment of enteric pathogens and hence help reduce infection. Infant formulae made from bovine milk are essentially devoid of HMOs, which creates a large impetus fo...
#1Yuichiro Onishi (Kyoto University)
#2Yuya Furushiro (Kyoto University)
Last. Takashi Kobayashi (Kyoto University)H-Index: 16
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Abstract Galactose was isomerized in pure water or in 10 mmol/L sodium phosphate buffer at 160 °C under pressurized conditions. The isomerization of galactose to tagatose and talose in phosphate buffer resulted in 14% and 1.4% yields, respectively, which were significantly higher than those obtained in subcritical pure water (0.6% and 6.3. Our results indicate that the galactose isomerization by Lobry de Bruyn-Alberda-van Ekenstein transformation rarely occurred at low pH due to the formation of...
#1Yasuro Shinohara (Kinjo Gakuin University)H-Index: 2
#1Yasuro ShinoharaH-Index: 30
Last. Jun-ichi Furukawa (Hokkaido University)H-Index: 19
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Abstract The susceptibility to glycation of all d -glucose-containing reducing disaccharides (kojibiose, sophorose, nigerose, laminaribiose, maltose, cellobiose, isomaltose, and gentiobiose) was evaluated by Maillard browning and the percentages of their acyclic forms estimated using a novel method to evaluate reactivity toward oxime formation were compared for the first time. This new method is facile and applicable to non-labeled carbohydrates, and it is extremely sensitive, more so than any o...
#1Christopher L. Allison (CSU: Colorado State University)H-Index: 1
#2Alec Lutzke (CSU: Colorado State University)H-Index: 8
Last. Melissa M. Reynolds (CSU: Colorado State University)H-Index: 21
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Abstract The beneficial effects provided by chitosan oligosaccharides (COS) make them of interest in medical research. The monomers that constitute COS confer distinct properties, so controlling COS composition during their production is significant. In this work, we degraded chitin and chitosan polymers and identified low molecular weight products such as COS that formed, using electrospray ionization time-of-flight mass spectrometry. Our results show that hydrochloric acid, hydrogen peroxide, ...
#1Panyakorn Taweechat (Chula: Chulalongkorn University)H-Index: 1
#2Ras B. Pandey (USM: University of Southern Mississippi)H-Index: 19
Last. Pornthep Sompornpisut (Chula: Chulalongkorn University)H-Index: 20
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Abstract Hyaluronic acid (HA) is a biopolymer of disaccharide with two alternate glycosidic bonds, β(1,3) and β(1,4). A molecular dynamics study presented here unveiled conformational variability in association with the flexibility of the glycosidic linkers, which depends on the number of disaccharide units. HA chain maintains a rigid rod-like conformation with short chain lengths. Crossover from a rod-like to a random−coil conformation is observed with increasing the chain length. The conformat...
#1Xin Meng (Tianjin University of Science and Technology)H-Index: 7
#2Xujing Lian (Tianjin University of Science and Technology)
Last. Yan Zhang (SDU: Shandong University)H-Index: 35
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Abstract A novel 2-fluorodeoxyglucose conjugated derivative of paclitaxel was efficiently synthesized using a linker between 2′-OH of paclitaxel and C1-hydroxyl group of 2-fluorodeoxyglucose. In preparation of the prodrug, allyl carbonates were selected as the protective group and the efficient one-step removal of allyloxycarbonyl groups at the end of the synthesis using palladium chemistry gave the target molecule in good yield. The prodrug not only improved the pharmaceutical properties of pac...
#1M.F. Guimarães (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 1
#1M. F. GuimarãesH-Index: 1
Last. L.A. dos Santos (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 4
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Abstract Nanocrystalline chitosan (NCC) is a modified form of chitosan, prepared from the method for obtaining chitosan acetate (CA). Due to the greater crystallinity of chitosan nanoparticles in relation to CA, NCC is more thermally stable and thus has great potential in the development of a new generation of biomaterials potentially useful in regenerative medicine and tissue engineering. NCC is also characterized by having similar properties to its precursor chitosan, such as its biocompatibil...
Abstract Bacterial cellulose(BC) is a kind of extracellular polymer synthesized by bacteria and it has very wide applications in many fields. However, the application of BC in a large commercial scale can still not be fulfilled due to the low yield and demanding for BC membranes with very different properties. To this end, a new BC-producer Komagataeibacter rhaeticus TJPU03 was isolated from rotten orange peel, which produced 8.28 ± 0.27 g/L(dry weight) in standard HS medium at the 10th day. The...
Top fields of study
Organic chemistry