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Modern Pathology
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Papers 5831
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#1Basile Tessier-Cloutier (UBC: University of British Columbia)H-Index: 9
#2Kim E. Kortekaas (LUMC: Leiden University Medical Center)H-Index: 2
Last. Lily Proctor (UBC: University of British Columbia)H-Index: 1
view all 15 authors...
The recent literature has shown that vulvar squamous cell carcinoma (VSCC) can be stratified into two prognostically relevant groups based on human papillomavirus (HPV) status. The prognostic value of p53 for further sub-stratification, particularly in the HPV-independent group, has not been agreed upon. This disagreement is likely due to tremendous variations in p53 immunohistochemical (IHC) interpretation. To address this problem, we sought to compare p53 IHC patterns with TP53 mutation status...
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#2Wenya Linda Bi (Harvard University)H-Index: 23
Last. Fausto J. Rodriguez (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 11
view all 7 authors...
Telomeres are nucleoprotein complexes located at the termini of eukaryotic chromosomes that prevent exonucleolytic degradation and end-to-end chromosomal fusions. Cancers often have critically shortened, dysfunctional telomeres contributing to genomic instability. Telomere shortening has been reported in a wide range of precancerous lesions and invasive carcinomas. However, the role of telomere alterations, including the presence of alternative lengthening of telomeres (ALT), has not been studie...
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#1Jie Xu (University of Texas MD Anderson Cancer Center)H-Index: 19
#2Shaoying Li (University of Texas MD Anderson Cancer Center)H-Index: 18
Last. L. Jeffrey Medeiros (University of Texas MD Anderson Cancer Center)H-Index: 81
view all 3 authors...
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#1Rohit BhargavaH-Index: 33
#2Beth Z. ClarkH-Index: 7
Last. David J. Dabbs (UH: University of Hawaii)H-Index: 1
view all 5 authors...
Magee Equations™ are multivariable models that can estimate oncotype DX® Recurrence Score, and Magee Equation 3 has been shown to have chemopredictive value in the neoadjuvant setting as a standalone test. The current study tests the accuracy of Magee Decision Algorithm™ using a large in-house database. According to the algorithm, if all Magee Equation scores are 25 (also “do not send”). All other cases could be considered for testing (labeled “send”). Of the 2196 ER+, HER2-negative cases sent f...
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#1Xiaoling Wang (ZJU: Zhejiang University)H-Index: 2
#2Xiao-dong Teng (ZJU: Zhejiang University)H-Index: 2
Last. Bo Wang (ZJU: Zhejiang University)H-Index: 28
view all 5 authors...
The American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) have recently issued updated guidelines on human epidermal growth factor receptor 2 (HER2) testing by fluorescence in situ hybridization (FISH) in invasive breast cancers. Cases with a HER2/chromosome enumeration probe 17 (CEP17) ratio of ≥2.0 but an average HER2 copy number of <4.0 signals per cell (ISH group 2) are no longer automatically classified as ISH positive. Herein, 30 cases in ISH group 2 were coll...
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#1Arnaud Da Cruz Paula (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 7
#2Edaise M. da Silva (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 3
Last. Robert A. Soslow (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 67
view all 19 authors...
Adult-type granulosa cell tumor (aGCT) is a rare malignant ovarian sex cord-stromal tumor, harboring recurrent FOXL2 c.C402G/p.C134W hotspot mutations in 97% of cases. These tumors are considered to have a favorable prognosis, however aGCTs have a tendency for local spread and late recurrences, which are associated with poor survival rates. We sought to determine the genetic alterations associated with aGCT disease progression. We subjected primary non-recurrent aGCTs (n = 7), primary aGCTs that...
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#1Harrison Tsai (Brigham and Women's Hospital)H-Index: 7
#2Jason L. Hornick (Brigham and Women's Hospital)H-Index: 66
Last. Marina Vivero (Brigham and Women's Hospital)H-Index: 13
view all 3 authors...
INSM1 is a diagnostic marker for neuroendocrine tumors originating in multiple anatomic sites. In the lung, INSM1 shows 76–97% sensitivity for neuroendocrine tumors overall. Our aim was to characterize INSM1 as a diagnostic marker for small cell carcinoma in the context of its epithelial, lymphoid, and mesenchymal morphologic mimics. Immunohistochemistry was performed on 231 tumors, including lung neuroendocrine tumors, nonneuroendocrine carcinomas of the thoracic cavity, diffuse large B-cell ly...
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#1Soo-Ryum Yang (Stanford University)H-Index: 3
#2Yosr BouhlalH-Index: 2
Last. Kimberly H. Allison (Stanford University)H-Index: 35
view all 8 authors...
In patients with invasive breast cancer, fluorescence in situ hybridization (FISH) testing for HER2 typically demonstrates the clear presence or lack of ERBB2 (HER2) amplification (i.e., groups 1 or 5). However, a small subset of patients can present with unusual HER2 FISH patterns (groups 2–4), resulting in diagnostic confusion. To provide clarity, the 2018 CAP/ASCO HER2 testing guideline recommends additional testing using HER2 immunohistochemistry (IHC) for determining the final HER2 status. ...
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#1Lingxin Zhang (HSS: Hospital for Special Surgery)
#2Sinchun Hwang (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 11
Last. Julia A. Bridge (UNMC: University of Nebraska Medical Center)H-Index: 54
view all 13 authors...
Herein we described the clinical, radiological, histological, and molecular characteristics of seven soft tissue aneurysmal bone cysts (STABCs) diagnosed and managed at a tertiary cancer center and to elucidate their relationship with myositis ossificans (MO). All cases had established imaging and histopathological diagnosis of STABC and were subject to fluorescence in situ hybridization (FISH) for USP6 rearrangement and Archer® FusionPlex® targeted RNA sequencing (RNASeq) analysis to identify t...
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#1Yuxin Liu (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 3
#2Monica Prasad-Hayes (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 10
Last. Michael Gaisa (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 4
view all 10 authors...
Women living with HIV (WLHIV) are at increased risk for human papillomavirus (HPV)-associated anal cancer. Given the “field effect” of HPV pathogenesis, some recommend that anal cancer screening should be limited to WLHIV with prior genital disease. This study aimed to characterize the relationship between anal and genital disease in WLHIV in order to better inform anal cancer screening guidelines. We retrospectively studied 153 WLHIV with biopsy-proven anal high-grade squamous intraepithelial l...
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