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Biotechnology Journal
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#1Muhammed Burak Demircan (Bilkent University)
#2Sehmus Tohumeken (Johns Hopkins University)
Last. Ayse B. Tekinay (Bilkent University)H-Index: 27
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The design and development of novel adjuvants, which enhance, accelerate, and prolong the immune responses triggered by antigens, hold great importance for targeting infectious diseases and cancer. Here, we designed a biotinylated peptide amphiphile (Biotin-PA) nanofiber, which serves as a noncovalent binding location for antigens. We showed that presenting the antigens on synthetic Biotin-PA nanofibers generated a higher immune response than the free antigens delivered with a CpG ODN (TLR9 agon...
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#1Kyungwoo LeeH-Index: 6
Last. Hyung-Jun Koo (Seoul National University of Science and Technology)H-Index: 19
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The topical delivery of siRNA-based therapies has opened new avenues for the treatment of skin disorders. The use of siRNA as a therapeutic, however, is limited due to its rapid degradation and poor cellular uptake. Furthermore, the top layer of skin, the stratum corneum, is a major barrier to the delivery of topical agents. There is an unmet need for efficient topical formulations for delivering siRNA to the site of action. In this study, we used 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP)...
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#1Liyuan Zhang (THU: Tsinghua University)
#2Wei Guo (Shenyang Agricultural University)
Last. Yuan Lu (THU: Tsinghua University)H-Index: 13
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Synthetic biology has promoted the development of biosensors as tools for detecting trace substances. In the past, biosensors based on synthetic biology have been designed on living cells, but the development of cell biosensors has been greatly limited by defects such as GMO problem and the obstruction of cell membrane. However, the advent of cell-free synthetic biology addresses these limitations. Biosensors based on the cell-free protein synthesis system have the advantages of higher safety, h...
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Last. Bernd Nidetzky (Graz University of Technology)H-Index: 43
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Catalyst development for biochemical cascade reactions often follows a "whole cell approach" in which a single microbial cell is made to express all of the required enzyme activities. Although attractive in principle, the approach can encounter limitations when efficient overall flux from substrate to product necessitates precise balancing between the individual activities. Here, we show effective integration of major design strategies from synthetic biology to a coherent development of plasmid ...
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Expensive Protein A chromatography resins drive the need to maximize process productivity as well as resin capacity utilization. To this end, we explored two strategies. We termed the first one "super-batch," which utilizes a single short-bed-height column with rapid cycling to increase productivity, combined with variable load flow rates to enhance resin capacity utilization. The second one is multicolumn continuous chromatography, which utilizes multiple columns in the load zone to achieve hig...
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#1Yongyang LiuH-Index: 1
Last. Qiangbin Wang (CAS: Chinese Academy of Sciences)
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The neural membrane potential of nerve cells is the basis of neural activity production, which controls advanced brain activities such as memory, emotion, and learning. In the past decades, optical voltage indicator has emerged as a promising tool to decode neural activities with high-fidelity and excellent spatiotemporal resolution. In particular, the hybrid optical probes can combine the advantageous photophysical properties of different components such as voltage-sensitive molecules, highly f...
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#1Yvonne Yijuan Lim (NUS: National University of Singapore)H-Index: 3
#2Yung Seng Lee (NUS: National University of Singapore)H-Index: 28
Last. Delicia Shu Qin Ooi (NUS: National University of Singapore)H-Index: 2
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BACKGROUND Obesity is a complex, multifactorial disease that is increasing in prevalence despite extensive research and efforts to curb it. Over the last decade, gut microbiome has emerged as an important contributor to the pathogenesis of obesity. Microbiome profile is altered in obese phenotype and the causative role of microbiome in obesity is demonstrated in fecal microbiota transplantation studies. PURPOSE AND SCOPE Herein, current evidences supporting the role of gut microbiome in obesity ...
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#1Hemant Kumar Raut (SUTD: Singapore University of Technology and Design)H-Index: 14
#2Rupambika Das (SUTD: Singapore University of Technology and Design)H-Index: 2
Last. Seeram Ramakrishna (NUS: National University of Singapore)H-Index: 128
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Emerging biomaterials for tissue engineering applications witness a multitude of interaction (both along their interface and internally) with human tissue that also changes over time. Insufficient consideration of these spatial and temporal aspects of biomaterial-tissue interactions often raise biocompatibility concerns. This review focuses on strategies implemented in some of the recently developed biomaterials - particularly for soft and hard tissue regeneration or replacement - to overcome po...
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