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Metabolic Brain Disease
IF
2.41
Papers
2020
Papers 2019
1 page of 202 pages (2,019 results)
Newest
#1Mohammad Taghi Mansouri (Ahvaz Jundishapur University of Medical Sciences)H-Index: 16
#2Bahareh Naghizadeh (Ahvaz Jundishapur University of Medical Sciences)H-Index: 15
Last.Soheila Alboghobeish (Ahvaz Jundishapur University of Medical Sciences)H-Index: 5
view all 6 authors...
Opioid-induced neuroinflammation plays a role in the development of opioid physical dependence. Moreover, nitric oxide (NO) has been implicated in several oxidative and inflammatory pathologies. Here, we sought to determine whether treatment with venlafaxine during the development of morphine dependence could inhibit naloxone-precipitated withdrawal symptoms. The involvement of neuro-inflammation related cytokines, oxidative stress, and L-arginine (L-arg)-NO pathway in these effects were also in...
#1Abir Ben Bacha (KSU: King Saud University)H-Index: 14
#2Al-Orf Norah (KSU: King Saud University)
Last.Afaf El-Ansary (KSU: King Saud University)H-Index: 20
view all 6 authors...
The current study evaluated the protective and therapeutic potency of bee pollen in ameliorating the toxic effects of methylmercury (MeHg), by measuring certain biochemical parameters related to neurotransmission, neuroinflammation, apoptosis, and glutamate excitotoxicity in the male neonate brain. Healthy, pregnant female rats (N = 40) were randomly divided into 5 groups, each comprising10 male neonates, as follows: (i) neonates delivered by control mothers; (ii) neonates delivered by MeHg-trea...
#1Meric A. AltinozH-Index: 10
#2Aysel OzpinarH-Index: 8
Last.Emily Hacker (University of Pittsburgh)
view all 4 authors...
Increasing recent evidence suggests a key role of oligodendroglial injury and demyelination in the pathophysiology of Huntington’s Disease (HD) and the transcription factor PPARδ is critical for oligodendroglial regeneration and myelination. PPARδ directly involves in the pathogenesis of HD and treatment with a brain-permeable PPARδ-agonist (KD3010) alleviates its severity in mice. Erucic acid (EA) is also a PPARδ-ligand ω9 fatty acid which is highly consumed in Asian countries through ingesting...
#1Asmat Ullah KhanH-Index: 5
#2Muhammad Akram (GCUF: Government College University, Faisalabad)H-Index: 13
Last.Saeed Ahmad (UOS: University of Sargodha)H-Index: 1
view all 11 authors...
Epilepsy is a severe neural disorder that affects approximately fifty million individuals globally. Despite the fact that for most of the people with epilepsy, convulsions are better controlled by current accessible antiepileptic medicines, yet there are more than 30% of individuals affected with medically intractable epilepsy and around 30–40% of all patients with epilepsy affected by many adverse reactions and convulsion resistance to the present antiepileptic drugs. Consequently, various scie...
#1Meleshni Naicker (UKZN: University of KwaZulu-Natal)H-Index: 1
#2Nathlee S. Abbai (UKZN: University of KwaZulu-Natal)H-Index: 4
Last.Strinivasen Naidoo (UKZN: University of KwaZulu-Natal)H-Index: 9
view all 3 authors...
The associations between thyroid auto-immunity and neuro-psychiatric disorders are well-documented. However, there exists limited literature specifically linking auto-immune thyroid disease (AITD) to bipolar disorder (BD). Thus, we investigated the likely association between Hashimoto’s disease and BD through the extra-thyroidal localisation of thyroid-stimulating hormone receptor (TSH-R) and thyroglobulin (TG) in limbic regions of normal and bipolar human adult brain. Further, we hypothesised t...
#1Arafat Hussein Al-Dujaili (University of Kufa)H-Index: 2
#2Hussein Kadhem Al-Hakeim (University of Kufa)H-Index: 4
Last.Michael Maes (Chula: Chulalongkorn University)H-Index: 96
view all 4 authors...
Major depressive disorder (MDD) is associated with alterations in calcium (Ca) and magnesium (Mg), as well as circulating pro- and anti-inflammatory cytokines. Anti-inflammatory drugs are commonly used as adjuvant treatments for MDD. However, no studies examined the effects of a combinatorial treatment with sertraline and ketoprofen, an anti-inflammatory drug, on Ca and Mg levels in MDD. The present study examined a) differences in both cations between drug-naive MDD patients and controls, and b...
#1Mehrdokht MazdehH-Index: 9
#2Mehrdad ZamaniH-Index: 1
Last.Soudeh Ghafouri-Fard (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 19
view all 7 authors...
Vitamin D has been vastly acknowledged as a neuroactive steroid controlling neurodevelopment. As it exerts its functions through activation of vitamin D receptor (VDR), several studies have assessed the role of VDR in brain function. More recently, a number of long non-coding RNAs (lncRNAs) have been recognized that alter expression of VDR. In the current study, we evaluated expression of four VDR-related lncRNAs (LINC00511, LINC00346, SNHG6 and SNHG16) in peripheral blood of 40 epileptic patien...
#1Behnaz Salek Esfahani (Tabriz University of Medical Sciences)H-Index: 1
#2Jalal Gharesouran (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 8
Last.Maryam Rezazadeh (Tabriz University of Medical Sciences)H-Index: 8
view all 8 authors...
Multiple Sclerosis (MS) is a chronic inflammatory disease causing demyelination and neurodegeneration in the central nervous system (CNS). Although the exact etiology of MS is still unclear, both genetic and environmental elements are regarded as causative factors. Environmental factors can induce a cascade of events in immune system leading to neuronal death and nerve demyelination. This paper aims to compare the peripheral transcript levels of Ermin (ERMN) (a gene with putative role in cytoske...
#1Rezvan Noroozi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 9
#2Iman Azari (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 1
Last.Soudeh Ghafouri-Fard (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 19
view all 5 authors...
Multiple sclerosis (MS) is a devastating inflammatory disease of the central nervous system (CNS) associated with loss of myelin sheaths. The role of Schwan cells in the remyelination of MS lesions has been documented. However, the detailed steps of this process are unknown. Ninjurin 2 (NINJ2) encodes an adhesion protein with high expression in Schwann cells adjoining the distal piece of injured nerve. Based on the role of this protein in neurite outgrowth, it might participate in the process of...
The aim of this study was to evaluate the immune-inflammatory, metabolic, and nitro-oxidative stress (IMN their disability was evaluated using the Expanded Disability Status Scale (EDSS) and IMN 84.6% of all patients were correctly classified in these EDSS subgroups. We found that 36.3% of the variance in EDSS score was explained by age, Th17/T regulatory (Treg) and LDL/HDL ratios and homocysteine (all positively related) and body mass index (BMI) (inversely related). After adjusting for MS trea...
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