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Journal of Pharmaceutical Analysis
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#1Tingting Wang (JLU: Jilin University)
#2Di Zhang (JLU: Jilin University)
Last. Jingkai Gu (JLU: Jilin University)H-Index: 20
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Abstract The development of nano drug delivery systems (NDDSs) provides new approaches to fight against diseases. The NDDSs are specially designed to serve as carriers for the delivery of active pharmaceutical ingredients (APIs) to their target sites, which would certainly extend the benefit of their unique physicochemical characteristics, such as prolonged circulation time, improved targeting and avoiding of drug-resistance. Despite the remarkable progress achieved over the last three decades, ...
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#1Lingge Gao (Xi'an Jiaotong University)
#2Xing-Min Shi (Xi'an Jiaotong University)H-Index: 7
Last. Xili Wu (Xi'an Jiaotong University)
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Abstract Low temperature plasma (LTP) technology has shown outstanding application value in the pharmaceutical filed in recent ten years. This paper reviews the research advances on LTP, including its effects on enhancing or inhibiting drug activity, its combined use with drugs to treat cancers, its effects on the improvement of drug delivery system, its use in preparation of new inactivated virus vaccines, its use with mass spectrometry (MS) for rapid detection of drug quality, the anti-tumor a...
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#1Priya Sharma (BITS: Birla Institute of Technology and Science)H-Index: 1
#2Devendra Kumar (UNMC: University of Nebraska Medical Center)H-Index: 4
Last. Srikanth Mutnuri (BITS: Birla Institute of Technology and Science)H-Index: 9
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Abstract Nutrient recovery from source-separated human urine has attracted interest, as it is rich in nitrogen and phosphorus that can be utilized as fertilizer. However, urine also contains pharmaceuticals, steroid hormones, etc. and their removal is crucial as they have detrimental effects on the environment and human health. The current study focuses on investigating the degradation of pharmaceuticals using a double-chamber microbial fuel cell (MFC). Urine was spiked with four pharmaceuticals...
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The recently emerged SARS-CoV-2 caused a major outbreak of coronavirus disease 2019 (COVID-19) and instigated a widespread fear, threatening global health security. To date, no licensed antiviral drugs or vaccines are available against COVID-19 although several clinical trials are underway to test possible therapies. During this urgency situation, computational drug discovery methods provide an alternative to tiresome high-throughput screening, particularly in the hit-to-lead-optimization stage....
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#1Yuan Li (NCU: Nanchang University)
#2Mengqi Wan (NCU: Nanchang University)
Last. Xiaolei Wang (NCU: Nanchang University)
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Abstract A highly sensitive and selective method was developed for both UV–vis spectrophotometric and fluorimetric determination of organophosphorus pesticides (OPs). This method uses silver nanoparticles (AgNPs) modified with graphitic carbon nitride (g-C3N4). The AgNPs reduce the fluorescence intensity of g-C3N4. Acetylthiocholine (ATCh) can be catalytically hydrolyzed by AChE to form thiocholine, which induces aggregation of the AgNPs. This aggregation leads to the recovery of the blue fluore...
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Abstract Drug resistance is a great challenge in cancer therapy using chemotherapeutic agents. Administration of these drugs with siRNA is an efficacious strategy in this battle. Here, it was tried to incorporate siRNA and paclitaxel simultaneously into a novel nanocarrier. The selectivity of carrier to target cancer tissues was optimized through conjugation of folic acid (FA) and glucose (Glu) onto its surface. The structure of nanocarrier formed from ternary magnetic copolymers based on FeCo-p...
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#1Huizhen Zhang (SYSU: Sun Yat-sen University)H-Index: 6
#2Yongtao Wang (SYSU: Sun Yat-sen University)H-Index: 9
Last. Huichang Bi (SYSU: Sun Yat-sen University)H-Index: 22
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Abstract Lipotoxicity, caused by intracellular lipid accumulation, accelerates the degenerative process of cellular senescence, which has implications in cancer development and therapy. Previously, carnitine palmitoyltransferase 1C (CPT1C), a mitochondrial enzyme that catalyzes carnitinylation of fatty acids, was found to be a critical regulator of cancer cell senescence. However, whether loss of CPT1C could induce senescence as a result of lipotoxicity remains unknown. An LC/MS-based lipidomic ...
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Abstract Many studies have so far confirmed the efficiency of phytochemicals in the treatment of prostate cancer. Eupatorin, a flavonoid with a wide range of phytomedical activities, suppresses proliferation of and induces apoptosis in multiple cancer cell lines. However, low solubility, poor bioavailability, and rapid degradation limit its efficacy. The aim of our study was to evaluate whether the use of mPEG-b-PLGA coated iron oxide nanoparticles as a carrier could enhance the therapeutic effi...
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Abstract Researches towards detection of human papillomavirus (HPV) high risk samples were carried out by polymerase chain reaction (PCR) coupled with microchip electrophoresis (MCE). Herein, we introduced a simple, rapid, automated method for detecting high risk samples HPV16 and HPV18. In this research, general primers were initially selected to obtain sufficient detectable yield by PCR to verify feasibility of MCM method for HPV detection, then type-specific primers were further used to evalu...
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#1Christelle Machon (HCL Technologies)
#1Christelle MachonH-Index: 7
Last. Jerome Guitton (HCL Technologies)
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Abstract 5-Fluorouracil (5-FU) is an anticancer drug extensively used for different cancers. Intracellular metabolic activation leads to several nucleoside and nucleotide metabolites essential to exert its cytotoxic activity on multiple cellular targets such as enzymes, DNA and RNA. In this paper, we describe the development of a method based on liquid chromatography coupled with high resolution mass spectrometry suitable for the simultaneous determination of the ten anabolic metabolites (nucleo...
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Top fields of study
Analytical chemistry
Detection limit
Mass spectrometry
High-performance liquid chromatography
Chemistry
Chromatography