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Redox biology
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7.79
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1374
Papers 1374
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#1Wen Shen (TU: Temple University)
#2Chao Gao (TU: Temple University)
Last.Hong Wang (TU: Temple University)H-Index: 39
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Abstract Homocysteine-Methionine (HM) cycle produces universal methyl group donor S-adenosylmethione (SAM), methyltransferase inhibitor S-adenosylhomocysteine (SAH) and homocysteine (Hcy). Hyperhomocysteinemia (HHcy) is established as an independent risk factor for cardiovascular disease (CVD) and other degenerative disease. We selected 115 genes in the extended HM cycle (31 metabolic enzymes and 84 methyltransferases), examined their protein subcellular location/partner protein, investigated th...
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#1Laura Casares (Dund.: University of Dundee)
Last.Eduardo Muñoz (UCO: University of Córdoba (Spain))H-Index: 38
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Abstract Cannabidiol (CBD) is a major non-psychotropic phytocannabinoid that attracted a great attention for its therapeutic potential against different pathologies including skin diseases. However, although the efficacy in preclinical models and the clinical benefits of CBD in humans have been extensively demonstrated, the molecular mechanism(s) and targets responsible for these effects are as yet unknown. Herein we characterized at the molecular level the effects of CBD on primary human kerati...
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#1Mercedes Muñoz (Complutense University of Madrid)H-Index: 12
#2María Elvira López-Oliva (Complutense University of Madrid)H-Index: 7
Last.Dolores Prieto (Complutense University of Madrid)H-Index: 23
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Abstract Oxidative stress-associated endothelial dysfunction is a key pathogenic factor underlying the microvascular complications of metabolic disease. NADPH oxidase (Nox) is a major source of oxidative stress in diabetic nephropathy and chronic kidney disease, despite Nox4 and Nox2 have been identified as relevant sources of vasodilator endothelial H2O2.The present study was sought to investigate the role of Nox enzymes in renal vascular oxidative stress and endothelial dysfunction in a rat mo...
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#1Luis Marte (UPF: Pompeu Fabra University)
#2Susanna Boronat (UPF: Pompeu Fabra University)H-Index: 8
Last.Elena Hidalgo (UPF: Pompeu Fabra University)H-Index: 33
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Abstract Signaling cascades respond to specific inputs, but also require active interventions to be maintained in their basal/inactive levels in the absence of the activating signal(s). In a screen to search for protein quality control components required for wild-type tolerance to oxidative stress in fission yeast, we have isolated eight gene deletions conferring resistance not only to H2O2 but also to caffeine. We show that dual resistance acquisition is totally or partially dependent on the t...
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#1Kaibo Xie (RUB: Ruhr University Bochum)H-Index: 2
#2Marharyta Varatnitskaya (RUB: Ruhr University Bochum)
Last.Lars I. Leichert (RUB: Ruhr University Bochum)H-Index: 18
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Abstract Neutrophils produce a cocktail of oxidative species during the so-called oxidative burst to attack phagocytized bacteria. However, little is known about the neutrophils' redox homeostasis during the oxidative burst and there is currently no consensus about the interplay between oxidative species and cellular signaling, e.g. during the initiation of the production of neutrophil extracellular traps (NETs). Using the genetically encoded redox sensor roGFP2, expressed in the cytoplasm of th...
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#1Karl Köhnlein (FSU: University of Jena)
#2Nadine Urban (FSU: University of Jena)H-Index: 3
Last.Lars-Oliver Klotz (FSU: University of Jena)H-Index: 49
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Abstract Human selenium binding protein 1 (SELENBP1) was originally identified as a protein binding selenium, most likely as selenite. SELENBP1 is associated with cellular redox and thiol homeostasis in several respects, including its established role as a methanethiol oxidase that is involved in degradation of a methionine catabolite, generating hydrogen sulfide (H2S) and hydrogen peroxide (H2O2). As both H2S and reactive oxygen species (such as H2O2) are major regulators of Caenorhabditis eleg...
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#1Jun Hui Sze (Griffith University)
#2Prahlad Raninga (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 1
Last.Kathryn Fay Tonissen (Griffith University)H-Index: 18
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Abstract Multiple myeloma (MM), the second most common haematological malignancy, is a clonal plasma B-cell neoplasm that forms within the bone marrow. Despite recent advancements in treatment, MM remains an incurable disease. Auranofin, a linear gold(I) phosphine compound, has previously been shown to exert a significant anti-myeloma activity by inhibiting thioredoxin reductase (TrxR) activity. A bis-chelated tetrahedral gold(I) phosphine complex [Au(d2pype)2]Cl (where d2pype is 1,2-bis(di-2-py...
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#1Simona-Adriana Manea (Romanian Academy)H-Index: 19
#2M.L. Vlad (Romanian Academy)
Last.Maya Simionescu (Romanian Academy)H-Index: 42
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Abstract NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are instrumental in all inflammatory phases of atherosclerosis. Dysregulated histone deacetylase (HDAC)-related epigenetic pathways have been mechanistically linked to alterations in gene expression in experimental models of cardiovascular disorders. Hitherto, the relation between HDAC and Nox in atherosclerosis is not known. We aimed at uncovering whether HDAC plays a role in mediating Nox up-regulation, oxidative stress, inflam...
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#1Yiqin Wang (SJTU: Shanghai Jiao Tong University)H-Index: 2
#2Xiaohui Liu (SJTU: Shanghai Jiao Tong University)H-Index: 3
Last.Jun Zhu (SJTU: Shanghai Jiao Tong University)H-Index: 15
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Abstract Hypoxia is widely considered as a limiting factor in vertebrate embryonic development, which requires adequate oxygen delivery for efficient energy metabolism, while nowadays some researches have revealed that hypoxia can induce stem cells so as to improve embryonic development. Erythroid differentiation is the oxygen delivery method employed by vertebrates at the very early step of embryo development, however, the mechanism how erythroid progenitor cell was triggered into mature erythr...
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#1Alessandra Pecorelli (NCSU: North Carolina State University)H-Index: 26
#2Valeria Cordone (NCSU: North Carolina State University)H-Index: 4
Last.Giuseppe Valacchi (Kyung Hee University)H-Index: 42
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Abstract Rett syndrome (RTT) is a progressive neurodevelopmental disorder mainly caused by mutations in the X-linked MECP2 gene. RTT patients show multisystem disturbances associated with an oxinflammatory status. Inflammasomes are multi-protein complexes, responsible for host immune responses against pathogen infections and redox-related cellular stress. Assembly of NLRP3/ASC inflammasome triggers pro-caspase-1 activation, thus, resulting in IL-1β and IL-18 maturation. However, an aberrant acti...
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Chemistry
Oxidative stress
Biochemistry
Biology
Cell biology