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#1Manisha SainiH-Index: 1
#2Abhay Singh Yadav (Kurukshetra University)H-Index: 5
Chronic respiratory diseases have become a major global concern in the recent times due to increased air pollution, especially in the urban population and asthma is most common among them. Increase in the recent few decades has projected India to be one of the leading countries prevalent to asthma. The chronic inflammation that occurs in asthma is known to generate reactive oxygen species that may lead to DNA damage. The main objective of the present study was to assess the frequency of micronuc...
#1Bhupender Kumar (DU: University of Delhi)H-Index: 2
Aim: Gemcitabine (GCB) remains the first line of defense for the treatment of pancreatic cancer. In recent years multiple therapy cycles with GCB have shown a lot of resistance towards pancreatic cancer treatment. Thus different methods have been attempted to improve its potency. This study aims to improve the potency of GCB using dietary molecule Fisetin, a flavonoid molecule commonly found in fruits and vegetables. Materials and Methods: Pancreatic cancer cell line Mia PaCa-2 was treated with ...
This commentary will give perspective of current status of Cyclic nucleotide gated channels (CNGCs) related finding in developmental, stress perception or other responses in plant system. CNGCs are newly discovered family of ion channels which opens upon binding of cyclic AMP or GMP at their cytoplasmic nucleotide binding (NBD) site. This commentary will also make researchers curious and enthusiast to further know the functional roles of uncharacterized CNGCs in plant system.
Metformin is a generic drug, used for treatment of type 2 diabetes mellitus. Metformin is known to lower the gluconeogenesis in lover cells and improves the insulin signalling in some target cells, thus exhibiting the anti-hyperglycemic activity. At the molecular level the Metformin affects the AMPK pathway and thus the energy level of the cells. Apart from its main action, it is also known to inhibit the activity of complex I of mitochondrial respiratory chain, though with unknown mechanism. Th...
#1Vimal K MauryaH-Index: 1
#2Swatantra KumarH-Index: 1
Last.Shailendra K. Saxena (King George's Medical University)H-Index: 2
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Human immunodeficiency virus (HIV) penetrates into the brain at initial phase of infection. Transmigration of HIV into the brain can be explained as “Trojan Horse” mechanism where infected CD4 T cells, monocytes and macrophages cross the blood brain barrier via cell independent manner. HIV infection to the brain may result in neuroAIDS with several neurological complications like dementia, mylopathy and neuropathy. Key barriers for the effective drug delivery to the brain are the complex structu...
#2Ashok N. Bhaskarwar (IITs: Indian Institutes of Technology)H-Index: 7
Oil-in-water emulsions are used in large amounts in hot-rolling mills of steel industries for cooling and lubrication of contacting metal surfaces. These emulsions are comparatively stable kinetically, and have high specific heats and heat transfer coefficients, and therefore can be used under high temperature and pressure conditions in hot-rolling mills of steel industries. These emulsions used in steel industries are however hazardous to the environment, and cannot be disposed of as such. The ...
#1Sapna Ratnakar (JNU: Jawaharlal Nehru University)
Hypoxia and HIF-1 are major factors which play essential roles in cancer cell adaptation to pathophysiological restrictions like poor vasculature and limited metabolic supplies caused by hypoxic tumor core. Transcription factor Yin-Yang 1 (YY1) has been linked with cell proliferation, cell cycle progression and deregulation; it exerts oncogenic effects contributing to cancer progression. YY1 and hypoxia/HIF1 independently share several common aspects of malignant transformation. In this review, ...
#1Jasvir Kaur (JNU: Jawaharlal Nehru University)H-Index: 1
The Green fluorescent protein chromophore housed inside the barrel has inspired scientists to use it as a marker to visualise cellular processes. Its emerging use in the synthetic form to develop dyes and understand photophysical and photochemical processes can also be seen. In this view, organic solvents are proving a better solvent system to study such processes. Though organic solvents are being used to study chromophore and its analogues, their influences on Green Fluorescent Protein are und...
#1Deeksha Gambhir Chopra (UCSF: University of California, San Francisco)H-Index: 1
Scientists gather at conferences to learn about the latest developments and discoveries in their fields. These meetings are usually bustling with poster presenters and spectators. The goal of this study was to identify and assess different personality types that stop by poster presentations. My data suggests that the poster audience can be classified into 10 different categories. Future studies are needed to further validate whether these “out-of-the” box audience will have a detrimental or bene...
The Finnish regional government reform currently under consideration will create a new tier of regional county governments, which will be responsible mainly for the provision of health and social care services. On the revenue side, counties will be financed mostly through grants from the central government and out-of-pocket payments (i.e. client fees). The funding model of the counties raises a number of questions from the point of view of the fiscal federalism literature. One important question...
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