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Methods of Molecular Biology
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#1Alexis Laurent (UNIL: University of Lausanne)H-Index: 1
#2Corinne Scaletta (UNIL: University of Lausanne)H-Index: 20
Last. Lee Ann ApplegateH-Index: 24
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Clinical experience gathered over two decades around therapeutic use of primary human dermal progenitor fibroblasts in burn patient populations has been at the forefront of regenerative medicine in Switzerland. Relative technical simplicity, ease of extensive serial multitiered banking, and high stability are major advantages of such cell types, assorted to ease of safety and traceability demonstration. Stringent optimization of cell source selection and standardization of biobanking protocols e...
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#1Jin Qi Liao (SZU: Shenzhen University)
#2Guangqian Zhou (SZU: Shenzhen University)H-Index: 20
Last. Yan Zhou (SZU: Shenzhen University)
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CRISPR/Cas9-mediated gene editing has been rapidly and widely applied in many organisms for delicate genetic manipulation, including human-induced pluripotent stem cells (iPSCs). Gene editing in human iPSCs is promising for genetics and biomedical research due to that gene-edited iPSC still possesses the potential to be differentiated into any cell lineages. In many cases, the generation of Cas9 expressing cell lines is a prerequisite toward performing successful editing of multiplex genes of in...
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#1Jakob Jeriha ('KCL': King's College London)H-Index: 1
#2Nikola Kolundzic ('KCL': King's College London)H-Index: 2
Last. Dusko Ilic ('KCL': King's College London)H-Index: 41
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Reprogramming somatic cells into induced pluripotent stem cells (iPSC) has provided a gateway for many novel discoveries in the field of tissue engineering, regenerative medicine and cell therapy. The need for an efficient, less laborious and fast reprogramming protocol under xeno-free, feeder-free and chemically defined conditions has never been greater. Here we describe a novel approach to reprogramming using the StemRNA 3rd Gen Reprogramming Kit (ReproCELL) which encompasses non-modified micr...
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#1Camillo Peracchia (UR: University of Rochester)H-Index: 36
In most tissues, cells in contact with each other directly intercommunicate via cell-to-cell channels aggregated at gap junctions. Direct cell-to-cell communication provides a fundamental mechanism for coordinating many cellular functions in mature and developing organs, as it enables free exchange of small cytosolic molecules. Gap junction channels are regulated by a chemical gating mechanism sensitive to cytosolic calcium concentration [Ca2+]i in the nanomolar range mediated by Ca2+-activated ...
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#1Amina Mohammadalipour (University of Texas Health Science Center at Houston)
#2Miguel F. Diaz (University of Texas Health Science Center at Houston)H-Index: 4
Last. Pamela L. Wenzel (University of Texas Health Science Center at Houston)H-Index: 17
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Hematopoietic stem cells (HSCs) are used in the clinic to provide life-saving therapies to patients with a variety of hematological malignancies and disorders. Yet, serious deficiencies in our understanding of how HSCs develop and self-renew continue to limit our ability to make this therapy safer and more broadly available to those who have no available donor. Finding ways to expand HSCs and develop alternate sources of HSCs is an urgent priority. In the embryo, a critical transition in develop...
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#1Xinghui Zhao (UK: University of Kentucky)
#2Cuiping Zhang (UK: University of Kentucky)
Last. Ying Liang (UK: University of Kentucky)H-Index: 15
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Hematopoietic stem cells (HSCs) are ultimately responsible for the lifelong renewal of all blood cell lineages. In the bone marrow (BM), HSCs reside in specialized microenvironments referred to as the "niche." HSC niche consists of complex components including heterogeneous cell populations, growth factors, and extracellular matrix molecules. The crosstalk between HSCs and their niche is essential to regulate the survival, self-renewal, migration, quiescence, and differentiation of HSCs. The app...
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#1Somayeh Ebrahimi-Barough (Tehran University of Medical Sciences)H-Index: 19
#2Jafar Ai (Tehran University of Medical Sciences)H-Index: 27
Last. Babak Arjmand (Tehran University of Medical Sciences)H-Index: 13
view all 8 authors...
Multiple sclerosis (MS) is the most common cause of neurological diseases. Although, there are some effective medications with regulatory approval for treating MS, they are only partially effective and cannot promote repairing of tissue damage directly which occurs in the central nervous system. Therefore, there is an essential need to develop novel therapeutic approaches for neuroprotection or repairing damaged tissue in MS. Accordingly, cell-based therapies as a novel therapeutic strategy have...
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#1Babak Arjmand (Tehran University of Medical Sciences)H-Index: 13
#2Parisa Goodarzi (Tehran University of Medical Sciences)H-Index: 9
Last. Bagher Larijani (Tehran University of Medical Sciences)H-Index: 26
view all 9 authors...
Schwann cells as glial cells in the peripheral nervous system can participate in neurons protection and forming myelin. Additionally, they are important for nerve pulse conduction supporting along axons. On the other hand, it was demonstrated that they are promising cells for the treatment of demyelinating disorders and also central nervous system damages. Herein, for therapeutic application, Schwann cells should be manufactured based on good manufacturing practice standards to achieve safe and ...
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#1Hamid Reza Aghayan (Tehran University of Medical Sciences)H-Index: 12
#2Moloud Payab (Tehran University of Medical Sciences)H-Index: 8
Last. Babak Arjmand (Tehran University of Medical Sciences)H-Index: 13
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Mesenchymal stem cells are one of the most attractive sources for stem cell research and therapy. Their safety and efficacy have been demonstrated in many clinical trials. Because of their low immunogenicity and immunomodulatory properties, allogenic MSCs have been transplanted in different clinical studies. MSCs could be in different adult- and fetal-derived tissues including pregnancy products. Placenta-derived mesenchymal stem cells (PLMSCs) that can be harvested without using any invasive pr...
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#1Babak Arjmand (Tehran University of Medical Sciences)H-Index: 13
#2Sepideh Alavi-Moghadam (Tehran University of Medical Sciences)H-Index: 4
Last. Bagher Larijani (Tehran University of Medical Sciences)H-Index: 26
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Recently, gene therapy as one of the most promising treatments can apply genes for incurable diseases treatment. In this context, vectors as gene delivery systems play a pivotal role in gene therapy procedure. Hereupon, viral vectors have been increasingly introduced as a hyper-efficient tools for gene therapy. Adenoviral vectors as one of the most common groups which are used in gene therapy have a high ability for humans. Indeed, they are not integrated into host genome. In other words, they c...
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