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ACS Biomaterials Science & Engineering
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Wear and corrosion damage of biomedical alloys alters the structure and electrochemical properties of the surface heterogeneously. It was hypothesized that local regions on the same surface systematically differ from one another in terms of their impedance characteristics. To test this hypothesis, CoCrMo discs exposed to electrosurgical and inflammatory-species driven damage were characterized using a localized impedance technique, nearfield electrochemical impedance spectroscopy (NEIS), to asse...
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Bone has great self-healing capacity, but above a certain critical size bone defects will not heal spontaneously, requiring intervention to achieve full healing. Amongst the synthetic calcium phosphate (CaP) bone replacement materials, brushite (CaHPO4·2H2O)-based materials are of particular interest, because of their degree of solubility and the related high potential to promote bone regeneration after dissolution. They can be produced tailor-made using modern 3D printing technology. While this...
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Mesenchymal stem cells (MSCs) based regenerative medicine is widely considered as a promising approach for repairing tissue and re-establishing function in spinal cord injury (SCI). However, low survival rate, uncontrollable migration and differentiation of stem cells after implantation, represent major challenges towards the clinical deployment of this approach. In this study, we fabricated three-dimensional MSCs laden microfibers via electrospinning in a rotating cell culture to mimic nerve ti...
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#1Lampouguin Yenkoidiok-Douti (UMD: University of Maryland, College Park)H-Index: 1
Last.Christopher M. JewellH-Index: 25
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Despite the success of vaccines in preventing many infectious diseases, effective vaccines against pathogens with ongoing challenges—such as HIV, malaria, and tuberculosis—remain unavailable. The emergence of new pathogen variants, the continued prevalence of existing pathogens, and the resurgence of yet other infectious agents motivate the need for new, interdisciplinary approaches to direct immune responses. Many current and candidate vaccines, for example, are poorly immunogenic, provide only...
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Localized drug delivery to lung cancer can overcome the limitations of systemic nanocarriers including low drug amount reaching lung tissue and severe off-target toxicity. The current work presented novel inhalable nanocomposites as non-invasive platforms for lung cancer therapy. Nanoparticulate liquid crystals (LCNPs) based on monoolein were developed for synergistic co-encapsulation of the cytotoxic chemotherapeutic drug, pemetrexed and the phytoherbal drug, resveratrol (PEM-RES-LCNPs). For ac...
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Magnetic nanoparticle clusters have been the subject of extensive studies examining their use as magnetic resonance imaging (MRI) probes in recent years due to their excellent contrast enhancement capability. The identification of the key factors affecting T2 (transverse) relaxivity in vitro and visualization in vivo is critical for the rational design of magnetic nanoclusters. In this review, we will discuss the relationship between the structural characteristics (cluster size, interparticle sp...
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Top fields of study
Self-healing hydrogels
Biophysics
Biomedical engineering
Nanotechnology
Chemistry
Materials science
Tissue engineering