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Nature Biomedical Engineering
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#1Issac J. Michael (UNIST: Ulsan National Institute of Science and Technology)H-Index: 3
#2Dong Young KimH-Index: 7
Last. Taek Soo Kim (Seoul National University Hospital)H-Index: 13
view all 12 authors...
The point-of-care detection of pathogens in biological samples in resource-limited settings should be inexpensive, rapid, portable, simple and accurate. Here, we describe a custom-made fidget spinner that rapidly concentrates pathogens in 1-ml samples of undiluted urine by more than 100-fold for the on-device colorimetric detection of bacterial load and pathogen identification. In Tiruchirappalli, India, the device enabled the on-site detection of infection with the naked eye within 50 min in ur...
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#1Jürgen Scheller (HHU: University of Düsseldorf)H-Index: 48
#2Philipp A. Lang (HHU: University of Düsseldorf)H-Index: 55
The intravenous administration of a formulation of interleukin-12 that binds to collagen in established ‘immunologically cold’ murine tumours enhances interferon-γ production by T cells and causes tumour remission, especially when in combination with immune checkpoint blockade therapy.
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#1Caitlin L. Maikawa (Stanford University)H-Index: 1
#2Anton A. A. Smith (Stanford University)H-Index: 1
Last. Santiago Correa (Stanford University)H-Index: 4
view all 19 authors...
Treatment of patients with diabetes with insulin and pramlintide (an amylin analogue) is more effective than treatment with insulin only. However, because mixtures of insulin and pramlintide are unstable and have to be injected separately, amylin analogues are only used by 1.5% of people with diabetes needing rapid-acting insulin. Here, we show that the supramolecular modification of insulin and pramlintide with cucurbit[7]uril-conjugated polyethylene glycol improves the pharmacokinetics of the ...
1 CitationsSource
The stabilization of co-administered insulin and pramlintide with cucurbit[7]uril-conjugated poly(ethylene glycol) in diabetic pigs enhances the overlap of their therapeutic windows.
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#1Xu-Dong Kong (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 3
#2Jun Moriya (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 1
Last. Christian Heinis (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 27
view all 7 authors...
The oral administration of peptide drugs is hampered by their metabolic instability and limited intestinal uptake. Here, we describe a method for the generation of small target-specific peptides (less than 1,600 Da in size) that resist gastrointestinal proteases. By using phage display to screen large libraries of genetically encoded double-bridged peptides on protease-resistant fd bacteriophages, we generated a peptide inhibitor of the coagulation Factor XIa with nanomolar affinity that resiste...
1 CitationsSource
#1David J. Brayden (UCD: University College Dublin)H-Index: 37
The selection of double-bridged peptides via in vitro phage display yields constrained cyclic peptides optimized for high therapeutic specificity and for stability against gastrointestinal proteases.
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#1Seung-min Park (Stanford University)H-Index: 10
#2Daeyoun D. Won (Stanford University)
Last. Elliot H. Choi (Case Western Reserve University)H-Index: 2
view all 24 authors...
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#1Thomas von Erlach (MIT: Massachusetts Institute of Technology)H-Index: 7
#2Sarah Saxton (MIT: Massachusetts Institute of Technology)H-Index: 2
Last. Cody Cleveland (MIT: Massachusetts Institute of Technology)H-Index: 9
view all 17 authors...
Monolayers of cancer-derived cell lines are widely used in the modelling of the gastrointestinal (GI) absorption of drugs and in oral drug development. However, they do not generally predict drug absorption in vivo. Here, we report a robotically handled system that uses large porcine GI tissue explants that are functionally maintained for an extended period in culture for the high-throughput interrogation (several thousand samples per day) of whole segments of the GI tract. The automated culture...
1 CitationsSource
#1Abdul W. Basit (UCL: University College London)H-Index: 49
#2Christine M. Madla (UCL: University College London)H-Index: 4
Last. Francesca Gavins (UCL: University College London)H-Index: 1
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A robotic culture system for the high-throughput analysis of drug transport in porcine gastrointestinal tissue explants accurately predicts the absorption of orally taken drugs in the human gut.
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#1Emma S. Gargus (NU: Northwestern University)H-Index: 2
#2Hunter B. Rogers (NU: Northwestern University)H-Index: 3
Last. Teresa K. Woodruff (NU: Northwestern University)H-Index: 73
view all 5 authors...
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