Abstract Introduction Greater reduction in estimated glomerular filtration rate (eGFR) after specific treatment for primary aldosteronism (PA) reflects improvement of glomerular hyperfiltration associated with PA and leads to better patient outcomes. However, little is known regarding the mechanisms underlying eGFR reduction after treatment for PA. Methods We analyzed data from the nationwide PA registry in Japan. Patients were assigned to adrenalectomy (n=438) and mineralocorticoid receptor (MR...
Abstract Introduction In Mayo Imaging Classification (MIC) for autosomal dominant polycystic kidney disease (ADPKD), height-adjusted total kidney volume (HtTKV) growth rate is estimated for classification. Estimated HtTKV slope, termed as eHTKV-α, is calculated by equation, [HtTKV at age t]=K(1+α/100)(t-A), where K=150 and A=0 are used in MIC. If eHTKV-α is nearly stable during standard-of-care period, the change in eHTKV-α from baseline can be used for estimation of treatment effect on HtTKV sl...
#1Mindy Pike(VUMC: Vanderbilt University Medical Center)H-Index: 1
#2Aseel Alsouqi(VUMC: Vanderbilt University Medical Center)
Last. Loren Lipworth(VUMC: Vanderbilt University Medical Center)H-Index: 40
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Abstract Introduction Patients are often instructed to engage in multiple weekly sessions of exercise to increase physical activity. We aimed to determine whether assignment to a supervised exercise regimen increases overall weekly activity in individuals with chronic kidney disease (CKD). Methods We performed a secondary analysis of a pilot randomized 2x2 factorial design trial examining the effects of diet and exercise (10-15% reduction in caloric intake, three supervised exercise sessions/wee...
Abstract Introduction Limited evidence is available regarding the post-discharge economic and readmission burdens of hyperkalemia. Methods Using the IBM MarketScan Commercial and Medicare-Supplemental Claims database (1/1/2010–12/31/2014), adult patients with a hospitalization with a hyperkalemia diagnosis (ICD-9-CM 276.7, hyperkalemia cohort) were 1:1 matched with patients with a hospitalization without evidence of hyperkalemia (non-hyperkalemia cohort) on age, chronic kidney disease stage, hea...
ABSTRACT Introduction Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive cyst enlargement, leading to kidney failure. Sirtuin-1 is upregulated in ADPKD and accelerates disease progression by deacetylating p53. Niacinamide is a dietary supplement that inhibits sirtuins at high doses. Methods We conducted an open-label, single arm intervention trial (Study 1, N=10), and a randomized, double blinded, placebo-controlled trial (Study 2, N=36) to assess the biological...