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Journal of Global Pharma Technology
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N-acetyl-para-aminophenol (APAP) or paracetamol–copper based complex with [Cu(APAP) 2 (OH) 2 .H 2 O] formula and noted Cu-APAP has been synthesized and characterized on the basis of elemental analysis, conductivity, IR and thermal (TG/DTG), NMR and electronic spectral studies. The value of molar conductance of the complex indicates a non-electrolyte nature. The antimicrobial activity of the complex was evaluated against several pathogenic microorganisms to assess its potential. The copper comple...
Published on Jul 2, 2019in Journal of Global Pharma Technology
Sampath Kumar Ramala (Annamalai University)
ABSTRACT: Nanotechnology is a promising technique to increase the bioavailability of herbal medicines. The present study was formulated to evaluate nanoparticles using an ethanolic extract of Cocculus pendulus . The sonoprecipitation technique was employed for the preparation of nanosuspensions with poloxamer-407 and PVA with many trails and finally the optimized nanosuspension demonstrated a mean particle size, polydispersity index, and zeta potential of 536 nm, 0.256, and − 17.6 mV, respective...
Our mother nature is an abundant treasure of medicinal plants. Many of the plants have active constituents like alkaloids, benzoquinones, catechols, carotenoids, flavonoids, glycosides, flavanol glycosides, steroid glycosides, glycoalkaloids, terpenoids, monoterpenoids, diterpenoids, triterpene saponins, sterols and polyphenols which are proved to be having tissue rejuvenation property. Which can be made use in critical conditions like nephropathy which can be curable only with kidney transplant...
The objective of the present work was to formulate and to characterize multi unit floating drug delivery system of Dipyridamole to increase the bioavailability and sustain the drug release properties up to 8 h with more predictable drug release kinetics that avoids all or nothing emptying effect. Dipyridamole floating mini-tablets were prepared by effervescent approach with melt granulation and direct compression techniques alone and in combination using Hydroxypropyl methylcellulose (HPMC) K100...
The present study aimed to synthesize mangiferin AgNPs and evaluate its in vitro antioxidant and cytotoxic properties. Mangiferin AgNPs was prepared using silver nitrate solution and characterized by SEM and Zeta potential measurement. In-vitro antioxidant and cytotoxic studies of mangiferin and its AgNPs were conducted by using DPPH and MTT assay method, respectively. The synthesized mangiferin AgNPs with particle size ranges from 25.30 - 40.79 nm. The charge of mangiferin AgNPs were confirmed ...
Objective: Proteins and enzymes are marginally stable macromolecules along with certain additives for converting them into suitable drug formulation. The research in pharmaceuticals claims the suitability of wide and variety range of micelles, reverse micelles, unsaturated fatty acids and their esters with glycols act as a protective fence for such therapeutic macromolecules against denaturants in colloidal form. The present study, address preformulation and compatibility study of different addi...
Published on Jun 1, 2019in Journal of Global Pharma Technology
Anton Smith A (Annamalai University), Akanksha , Arun R
Objective : Development of analytical methods is in need for the estimation of drugs in pure and different pharmaceutical formulations. A simple, sensitive, rapid, accurate, precise and economic Spectrophotometric and Spectrofluorimetric method were developed and validated for Nadolol in pure and Pharmaceutical formulations. Methods : The wave length (λ max ) used for the estimation of Nadolol is 267nm by Spectrophotometry, excitation (λ Ex )-267nm and emission (λ Em )-300nm by Spectrofluorimetr...
Asian tiger shrimp ( Penaeus monodon ) shell is an industrial waste which becomes one of the sources of carotenoids in the form of astaxanthin (3.3’-dihydroxy-β, β′-carotene-4.4′-dione) which has a very potential biological activity because it can work on target molecules. Astaxanthin in Asian tiger shrimp shell is well known to be lipophilic, being insoluble in water but soluble in organic solvents, one of which acetonitrile. The characteristics of astaxanthin were obtained through qualitative ...
Probiotics are living organisms that are used as food additives with beneficial effects on the healthy body by setting microbial balance in gastrointestinal tract. Lactic acid bacteria (LAB) as protective cultures are common probiotic organisms that are considered safe due to having specific characteristics. Main genera of LAB are Leuconostoc, Enterococcus, Lactobacillus, Lactococcus, Bifidobacterium, Pediococcus , and Streptococcus . These bacteria cause reduction of gastrointestinal diseases b...
Faloak bark extract has antibacterial, antioxidant and anticancer potential but no optimal solvent has found to extract the active compounds of faloak bark. Therefore, it is necessary to optimize the solvent against the faloak bark. This study aims to determine the optimum solvent of methanol, ethyl acetate, petroleum ether, and water in order to produce an optimal response value in the extract, total phenolic, and inhibitory results in antifungal tests. Extracts obtained through reflux extracti...
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