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Cell discovery
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#1Jia Liu (CAS: Chinese Academy of Sciences)
#2Ruiyuan CaoH-Index: 1
Last. Manli Wang (CAS: Chinese Academy of Sciences)H-Index: 14
view all 10 authors...
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#1Yiqing Chen (Fudan University)H-Index: 4
#2Xi Chen (Fudan University)H-Index: 2
Last. Qiyao Wang (ECUST: East China University of Science and Technology)
view all 14 authors...
African swine fever virus (ASFV) is highly contagious and can cause lethal disease in pigs. ASFV is primarily replicated in the cytoplasm of pig macrophages, which is oxidative and caused constant damage to ASFV genome. ASFV AP endonuclease (AsfvAP) catalyzes DNA cleavage reaction at the abasic site and is a key enzyme of ASFV base excision repair (BER) system. Although it plays an essential role in ASFV survival in host cells, the basis underlying substrate binding and cleavage by AsfvAP remain...
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#1Yadi Zhou (Cleveland Clinic)H-Index: 7
#2Yuan Hou (Cleveland Clinic)H-Index: 1
Last. Feixiong Cheng (Cleveland Clinic Lerner College of Medicine)H-Index: 34
view all 6 authors...
Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and mortality. However, there are currently no effective drugs targeting 2019-nCoV/SARS-CoV-2. Drug repurposing, representing as an effective drug discovery strategy from existing drugs, could shorten the time and reduce the cost compared to de novo drug discovery. In this study, we present an i...
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#1Qingliang Zheng (Tongji University)H-Index: 1
#2Haili Gan (Tongji University)
Last. Liping Jin (Tongji University)H-Index: 2
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N1-methyladenosine (m1A) is one of the important post-transcriptional modifications in RNA and plays an important role in promoting translation or decay of m1A-methylated messenger RNA (mRNA), but the “reader” protein and the exact biological role of m1A remain to be determined. Here, we identified that nine potential m1A “reader” proteins including YTH domain family and heterogeneous nuclear ribonucleoprotein by mass spectrometry, and among them, YTH domain-containing protein 3 (YTHDF3), could ...
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#1Cheng Xu (USTC: University of Science and Technology of China)
#2Hui-Jing Liu (USTC: University of Science and Technology of China)
Last. Guo-Qiang Bi (USTC: University of Science and Technology of China)H-Index: 26
view all 9 authors...
Excitatory synapses in the mammalian brain exhibit diverse functional properties in transmission and plasticity. Directly visualizing the structural correlates of such functional heterogeneity is often hindered by the diffraction-limited resolution of conventional optical imaging techniques. Here, we used super-resolution stochastic optical reconstruction microscopy (STORM) to resolve structurally distinct excitatory synapses formed on dendritic shafts and spines. The majority of these shaft syn...
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#1Yanan Cao (SJTU: Shanghai Jiao Tong University)H-Index: 10
#2Lin Li (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Weiqing Wang (SJTU: Shanghai Jiao Tong University)H-Index: 37
view all 10 authors...
2 CitationsSource
#1Huwen Wang (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Zezhou Wang (Fudan University)H-Index: 1
Last. Jinyan Huang (SJTU: Shanghai Jiao Tong University)H-Index: 1
view all 15 authors...
An outbreak of clusters of viral pneumonia due to a novel coronavirus (2019-nCoV/SARS-CoV-2) happened in Wuhan, Hubei Province in China in December 2019. Since the outbreak, several groups reported estimated R0 of Coronavirus Disease 2019 (COVID-19) and generated valuable prediction for the early phase of this outbreak. After implementation of strict prevention and control measures in China, new estimation is needed. An infectious disease dynamics SEIR (Susceptible, Exposed, Infectious, and Remo...
3 CitationsSource
#1Dan Tang (Sichuan University)
#2Chunjing Chen (Ha Tai: Xiamen University)
Last. Jinsong Duan (THU: Tsinghua University)H-Index: 1
view all 23 authors...
Super elongation complex (SEC) is a positive regulator of RNA polymerase II, which is required for HIV-1 proviral transcription. AFF1/4 is the scaffold protein that recruits other components of SEC and forms dimer depending on its THD domain (TPRL with Handle Region Dimerization Domain). Here we report the crystal structure of the human AFF4-THD at the resolution of 2.4 A. The α4, α5, and α6 of one AFF4-THD mediate the formation of a dimer and pack tightly against the equivalent part of the seco...
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#1Willa Yim (UTokyo: University of Tokyo)
#2Noboru Mizushima (UTokyo: University of Tokyo)H-Index: 109
Autophagy is a major intracellular degradation system that derives its degradative abilities from the lysosome. The most well-studied form of autophagy is macroautophagy, which delivers cytoplasmic material to lysosomes via the double-membraned autophagosome. Other forms of autophagy, namely chaperone-mediated autophagy and microautophagy, occur directly on the lysosome. Besides providing the means for degradation, lysosomes are also involved in autophagy regulation and can become substrates of ...
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#1Panke Qu (CAS: Chinese Academy of Sciences)H-Index: 2
#2Chao Zhang (CAS: Chinese Academy of Sciences)H-Index: 43
Last. Xia Jin (CAS: Chinese Academy of Sciences)H-Index: 30
view all 11 authors...
Zika virus (ZIKV) infection poses a serious threat to human health. However, no licensed vaccine or therapeutic drug is currently available for ZIKV. We have previously shown that recombinant ZIKV E80 protein induced potent neutralizing antibody response and protected mice from lethal viral challenge. In the present study, we isolated five ZIKV neutralizing monoclonal antibodies (mAbs) from E80-immunized mice. These five mAbs specifically bound and neutralized Asian-lineage ZIKV strains. Epitope...
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