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Chinese Journal of Joint Surgery
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退行性骨关节炎( OA)是肌肉骨骼系统最常见的疾病,可导致严重的关节疼痛及功能障碍。传统认为OA与退变及创伤有关,但是越来越多的证据表明OA不是单一的与衰老或生物学应力相关的疾病,而是“代谢紊乱”与“炎性衰老”等多因素的累积,脂质代谢、体液介质也参与疾病的起始和进展。《骨关节炎与软骨》中也提出OA是一种代谢疾病,骨骼、肌肉、滑膜和软骨等关节组成部分均受脂肪因子活性失调的影响。研究已证实脂肪因子是OA发病的关键调节因子之一,流行病学研究也证实血清胆固醇是OA进展的危险因素;在OA早期可观察到软骨内脂质沉积,蛋白组学也表明OA与脂质代谢之间有密切联系。此外,脂质代谢紊乱也是另一个退行性疾病动脉粥样硬化( AS)的主要危险因素。最近研究发现OA与AS存在明显共病现象,推测利用AS目前研究可为OA的防治开辟新思路。
Objective To investigate the clinical effects of total knee arthroplasty( TKA) for severe flexion deformity. Methods 38 patients who underwent TKA in our hospital from December 2010 to December 2013,were selected. The therapeutic effects were evaluated via the active range of motion,manual muscle testing,Muller knee stability rating and Hospital for Special Surgery of US. Results The AROM,MMT and Muller scores after the operation were significantly higher than the preoperative ones; the differen...
骨关节手术特别是髋膝关节置换手术,疼痛是患者常见的主观体验,也是人工关节手术无法回避的问题,疼痛制约着患者肢体功能恢复及影响中枢神经系统病理性重构,严重危害患者生理及社会心理健康,随着世界卫生组织将疼痛确定为继体温、脉搏、呼吸及血压之后的第五大生命体征[1],逐渐引起广泛关注。疼痛的产生是一个多环节、极其复杂的过程,单一的止痛机制不足以达到理想镇痛,近年来,多模式镇痛已成为全关节置换患者围手术期管理的重要组成部分,并成为临床镇痛技术的主要发展方向。
Objective To compare the incidence of failure following patellofemoral arthroplasty( PFA) and total knee arthroplasty( TKA) for isolated patellofemoral osteoarthritis and evaluate the efficacy of the two different treatment options.Methods The publications with patients who underwent PFA or TKA for patellofemoral osteoarthritis were systematically identified from the database of Chinese Biomedical Database,Medline and Embase.The data of demographics,implants( TKA,first or second-generation PFA),...
Objective To discuss clinical application of big size metal-on-metal total hip replacement with minimally invasive method for stage Ⅲ/Ⅳ avascular necrosis of the femoral head in the young and the middle-aged patients. Methods 32 patients (35 hips) whose femoral heads were stage Ⅲ/Ⅳ avascular necrosis were chosen, with age ranging from 24 to 59 years, 45 years in average. The average Harris score was 37.9. Minimally invasive improved posterolateral incision and the muscle space approach used; the...
Objective To compare the efficacy of arthroscopy assisted reduction and fixation with that of the conventional open reduction and internal fixation in tibial plateau fracture.Methods A retrospective analysis was conducted on 48 patients with tibial plateau fractures from April,2005 to April,2009.The patients were divided into Group A( open reduction and internal fixation,n = 22) and Group B( arthroscopy assisted reduction and fixation,n = 26).The average follow-up period was 15.3 months,ranging ...
Objective To investigate whether single nucleotide polymorphisms (SNPs) and haplotypes of IL-1β are associated with susceptibility to advanced knee osteoarthritis (KOA) in Han population of China.Methods A case-control study was carried out. 120 cases of Chinese Han patients with knee OA were selected, while 130 healthy people were set as control group, who were matched in age and sex. The serum level of IL-1β was measured with an enzyme-linked immunosorbent assay (ELISA). SNPs at positions-511C...
Around the world,osteoporosis has gradually become a serious social and health issues.Osteoporotic hip fracture is the most severe complication.Arthroplasty is one of the most effective way to treat this complication which can significantly improve patients' life quality.Approximately one million joint arthroplasties are performed annually worldwide,but periprosthetic osteolysis and subsequent aseptic joint loosening happen in approximately 12% of patients within 10 years of the initial surgery....
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Objective To investigate relationship between the morphologic characteristics of femoral lateral condyle and morphological changes of anterior cruciate ligament(ACL) femoral footprint,and to explore the individual design strategy of anatomic double-bumdle ACL reconstruction.Methods60 adult knees were conventional dissected,and the longitudinal axis length of ACL was measured.Internal surface shape of lateral femoral condyle was observed,and the angle between ACL footprint axis and femoral shaft ...
Objective To explore the influence of bone cement on hemorheology in animal test.Methods New Zealand white rabbits were randomly divided into two groups with 12 rabbits each:experimental group(bone cement) and control group(none-bone-cement).Experimental group were infused with bone cement in medullary cavity of proximal femur while control group were not.Blood samples of the rabbits were taken before operation,at 10 minute,one hour,three hours,and 24 hours after operation.Hemorheology parameter...
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Top fields of study
Surgery
Osteoarthritis
Arthroplasty
Prosthesis
Femoral head
Medicine