Molecular and Clinical Oncology
Papers 1925
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#1Koji Iinuma (Gidai: Gifu University)
#2Kosuke Mizutani (Gidai: Gifu University)H-Index: 10
Last. Takuya Koie (Gidai: Gifu University)H-Index: 3
view all 8 authors...
Radiation therapy with permanent iodine-125 implant brachytherapy is well established for curable prostate cancer. To maximize the therapeutic potential of brachytherapy, delivered radiation doses have been increased accompanied by refined intraoperative procedures of radioactive seeds placement. However, dose escalation is a double-edged sword in prostate brachytherapy; it could induce rectal toxicity, yet is successful in curable treatment in prostate cancer. To reduce irradiation of the rectu...
#1Takayuki Kosaka (Gunma University)H-Index: 24
#2Kimihiro Shimizu (Gunma University)H-Index: 29
Last. Ken Shirabe (Gunma University)H-Index: 52
view all 12 authors...
Recent advances in imaging technology have enhanced the detection rate of small-sized peripheral lung cancers. The present study aimed to identify the clinicopathological differences between patients with small-sized peripheral squamous cell carcinoma (SCC) and adenocarcinoma (ADC). Patients with lung cancer who underwent radical surgical resection at Gunma University Hospital between July 2007 and October 2012 were retrospectively analyzed. Patients who exhibited small-sized peripheral tumors (...
#1Motohiro Murakami (University of Tsukuba)H-Index: 1
#2Nobuyoshi FukumitsuH-Index: 20
Last. Hideyuki Sakurai (University of Tsukuba)H-Index: 29
view all 10 authors...
HCC may recur following surgery or radiofrequency ablation. Proton beam therapy (PBT) is a type of radiotherapy that achieves excellent local control of HCC without severe toxicity. The present study reported the long-term outcome of 3 HCC patients who each received 4 repeat courses of PBT. All patients had a hepatitis B or C viral infection. A total of 14 lesions were treated using a curative PBT protocol and irradiated liver volumes in each treatment were 7-50% of the total liver volume. Liver...
#1Shintaro TakakiH-Index: 20
#2Takayuki FukuharaH-Index: 12
Last. Keiji TsujiH-Index: 9
view all 4 authors...
Although sorafenib is the standard treatment for patients with advanced hepatocellular carcinoma (HCC), the predictive factors sorafenib tolerance in intermediate-stage HCC cannot be accurately determined. The aim of the current study was to identify the predictive characteristics for the continuation of sorafenib treatment (≥400 mg) in patients with transarterial chemoembolization (TACE)-refractory intermediate HCC and to identify candidates for second-line sorafenib treatment. A total of 33 TA...
#1Satoru Okada (Kyoto Prefectural University of Medicine)H-Index: 3
#2Aya Miyagawa‑Hayashino (Kyoto Prefectural University of Medicine)
Last. Masayoshi Inoue (Kyoto Prefectural University of Medicine)H-Index: 29
view all 9 authors...
Trousseau's syndrome is characterized as an unexpected, cancer-related thrombotic event, such as a cerebral infarction or a deep vein thrombosis/pulmonary embolism. We describe the first reported case of Trousseau's syndrome with pulmonary pleomorphic carcinoma and aggressive features. A 74 year-old man presenting with a pulmonary mass, which was identified as pleomorphic carcinoma with extensive lymph node involvement, in the left lower lobe, underwent a left lower lobectomy. Immunohistochemica...
#1Maiko Kitajima (Hirosaki University)H-Index: 5
#2Kasumi Mikami (Hirosaki University)H-Index: 2
Last. Tomohiro Osanai (Hirosaki University)H-Index: 25
view all 10 authors...
Assessment of skin condition is necessary for providing advice regarding skin self-care to patients with breast cancer who have undergone radiation therapy. Acute and chronic phases of radiodermatitis were analyzed in patients using objective assessment tools in the present study. A total of 18 women who received radiation therapy for breast cancer were enrolled in the present study and their skin surface temperature (SST), hydration level of the skin surface (HL), melanin intensity (MI) and ery...
#1Giovanni Ponti (University of Modena and Reggio Emilia)H-Index: 23
#2Giovanni Pellacani (University of Modena and Reggio Emilia)H-Index: 47
Last. Marco Manfredini (University of Modena and Reggio Emilia)H-Index: 11
view all 10 authors...
In difference to other solid malignancies, the identification of biomarkers for the prediction of malignant melanoma (MM) response to immunotherapy is limited. The aim of the current study was to evaluate the immunohistochemical (IHC) expression of MMR proteins in a cohort of MM metastatic patients receiving anti PD-1 treatments. The therapeutic response of patients was also retrospectively assessed. The cohort of the current study included 14 patients with advanced MM that had received anti PD-...
#1Takeaki Nagamine (Takasaki University of Health and Welfare)
#2Kizuku KadenaH-Index: 1
Last. Masahiko IhaH-Index: 6
view all 5 authors...
Cancer survivors are highly motivated to seek information about the use of dietary supplements and complementary nutritional therapies to improve their quality of life. Fucoidan, a sulfated polysaccharide extracted from brown marine alga, exhibits a wide range of bioactivities, including anticancer activity. As natural killer (NK) cells serve an important role in defenses against tumor cells, the present study examined the effects of fucoidan extracted from Cladosiphon Okamuranus on NK cell acti...
#1Takako YoshiiH-Index: 2
#2Hiroki HaraH-Index: 12
Last. Yoshihiro SaitoH-Index: 33
view all 9 authors...
Chemoradiotherapy (CRT) is a valuable treatment option for localized esophageal cancer. Conventional baseline chemotherapy for this type of cancer includes cisplatin and fluorouracil. Recently, CRT with leucovorin-fluorouracil-oxaliplatin (FOLFOX) has become popular due to its convenience and lower toxicity. In Japan, the use of oxaliplatin for esophageal cancer is not yet approved, so experience with this treatment is limited to cases with colorectal cancer. As such patients are not usually inc...
#1Chika Miyasaka (Kansai Medical University)H-Index: 4
#2Mitsuaki Ishida (Kansai Medical University)H-Index: 2
Last. Koji Tsuta (Kansai Medical University)H-Index: 48
view all 7 authors...
Wagner-Meissner corpuscles are specialized mechanoreceptors located in the dermal papillae. Wagner-Meissner corpuscle-like structures are occasionally a component of certain types of tumors, such as melanocytic nevus and neurofibroma. Benign tumorous lesion entirely composed of Wagner-Meissner corpuscles are described as Wagner-Meissner neurilemmoma, and only four such cases have been reported. Here, we report the first case of Wagner-Meissner neurilemmoma in a patient with neurofibromatosis typ...
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Cell cycle
Molecular medicine