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Journal of Computational Neuroscience
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Papers 1147
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#1Daniel Ioan (Politehnica University of Bucharest)H-Index: 10
#2Ruxandra Bărbulescu (Politehnica University of Bucharest)
Last.Gabriela Ciuprina (Politehnica University of Bucharest)H-Index: 9
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The paper presents a hierarchical series of computational models for myelinated axonal compartments. Three classes of models are considered, either with distributed parameters (2.5D EQS–ElectroQuasi Static, 1D TL-Transmission Lines) or with lumped parameters (0D). They are systematically analyzed with both analytical and numerical approaches, the main goal being to identify the best procedure for order reduction of each case. An appropriate error estimator is proposed in order to assess the accu...
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The detrusor, a key component of the urinary bladder wall, is a densely innervated syncytial smooth muscle tissue. Random spontaneous release of neurotransmitter at neuromuscular junctions (NMJs) in the detrusor gives rise to spontaneous excitatory junction potentials (SEJPs). These sub-threshold passive signals not only offer insights into the syncytial nature of the tissue, their spatio-temporal integration is critical to the generation of spontaneous neurogenic action potentials which lead to...
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Interaction between sensory and motor cortices is crucial for perceptual decision-making, in which intracortical inhibition might have an important role. We simulated a neural network model consisting of a sensory network (NS) and a motor network (NM) to elucidate the significance of their interaction in perceptual decision-making in association with the level of GABA in extracellular space: extracellular GABA concentration. Extracellular GABA molecules acted on extrasynaptic receptors embedded ...
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#1Mathieu Desroches (IRIA: French Institute for Research in Computer Science and Automation)H-Index: 14
#2Olivier Faugeras (IRIA: French Institute for Research in Computer Science and Automation)H-Index: 74
Last.Massimo MantegazzaH-Index: 1
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Cortical spreading depression (CSD) is a wave of transient intense neuronal firing leading to a long lasting depolarization block of neuronal activity. It is a proposed pathological mechanism of migraine with aura. Some molecular/cellular mechanisms of migraine with aura and of CSD have been identified studying a rare mendelian form: familial hemiplegic migraine (FHM). FHM type 1 & 2 are caused by mutations of the CaV2.1 Ca2+ channel and the glial Na+ / K+ pump, respectively, leading to facilita...
1 CitationsSource
#1Noemi Montobbio (UNIBO: University of Bologna)H-Index: 2
#2Giovanna Citti (UNIBO: University of Bologna)H-Index: 19
Last.Alessandro Sarti (EHESS: School for Advanced Studies in the Social Sciences)H-Index: 25
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#1Jiangling Song (Northwest University (United States))H-Index: 1
#2Luis Paixao (Harvard University)H-Index: 1
Last.M. Brandon Westover (Harvard University)H-Index: 28
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Acute hepatic encephalopathy (AHE) due to acute liver failure is a common form of delirium, a state of confusion, impaired attention, and decreased arousal. The electroencephalogram (EEG) in AHE often exhibits a striking abnormal pattern of brain activity, which epileptiform discharges repeat in a regular repeating pattern. This pattern is known as generalized periodic discharges, or triphasic-waves (TPWs). While much is known about the neurophysiological mechanisms underlying AHE, how these mec...
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#1Patrick Toglia (USF: University of South Florida)H-Index: 5
#2Ghanim Ullah (USF: University of South Florida)H-Index: 17
The effect of pathological phenomena such as epileptic seizures and spreading depolarization (SD) on mitochondria and the potential feedback of mitochondrial dysfunction into the dynamics of those phenomena are complex and difficult to study experimentally due to the simultaneous changes in many variables governing neuronal behavior. By combining a model that accounts for a wide range of neuronal behaviors including seizures, normoxic SD, and hypoxic SD (HSD), together with a detailed model of m...
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#1Nikolaos Chrysanthidis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
#2Florian Fiebig (KTH: Royal Institute of Technology)H-Index: 2
Last.Anders Lansner (KTH: Royal Institute of Technology)H-Index: 41
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We present an electrophysiological model of double bouquet cells and integrate them into an established cortical columnar microcircuit model that has previously been used as a spiking attractor model for memory. Learning in that model relies on a Hebbian-Bayesian learning rule to condition recurrent connectivity between pyramidal cells. We here demonstrate that the inclusion of a biophysically plausible double bouquet cell model can solve earlier concerns about learning rules that simultaneously...
2 CitationsSource
#1Pedro D. MaiaH-Index: 6
#2Ashish RajH-Index: 21
Last.J. Nathan Kutz (UW: University of Washington)H-Index: 38
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We introduce a computational model for the cellular level effects of firing rate filtering due to the major forms of neuronal injury, including demyelination and axonal swellings. Based upon experimental and computational observations, we posit simple phenomenological input/output rules describing spike train distortions and demonstrate that slow-gamma frequencies in the 38–41 Hz range emerge as the most robust to injury. Our signal-processing model allows us to derive firing rate filters at the...
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