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#1Ida K. HaugenH-Index: 22
#2David T. Felson (NIHR: National Institute for Health Research)H-Index: 139
Last. Féline P.B. Kroon (LUMC: Leiden University Medical Center)H-Index: 12
view all 19 authors...
Objectives Further knowledge about typical hand osteoarthritis (OA) characteristics is needed for the development of new classification criteria for hand OA. Methods In a cross-sectional multi-centre international study, a convenience sample of patients from primary and secondary/tertiary care with a physician-based hand OA diagnosis (n = 128) were compared with controls with hand complaints due to inflammatory or non-inflammatory conditions (n = 70). We examined whether self-reported, clinical,...
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#1Maarten R. Hillen (UU: Utrecht University)H-Index: 7
#2Katia Urso (GSK: GlaxoSmithKline)
Last. Timothy R D J Radstake (GSK: GlaxoSmithKline)
view all 10 authors...
Tripartite motif-containing protein 21 ( TRIM21 )/Ro52 is an immunoglobulin receptor that together with Ro60 makes up Sjogren’s syndrome-antigen A (SSA). A 60%–80% of patients with primary Sjogren’s syndrome (pSS) have anti-SSA autoantibodies and they form part of the pSS diagnosis. TRIM21 is a cytosolic Fc-receptor that mediates neutralisation of opsonised viruses and other particles, acting as a last line of defence against viruses that are recognised by antibodies but still manage to penetrat...
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#1Vasco C. Romão (IMM: Instituto de Medicina Molecular)H-Index: 10
#2I. Cordeiro (IMM: Instituto de Medicina Molecular)H-Index: 6
Last. João Eurico Fonseca (IMM: Instituto de Medicina Molecular)H-Index: 34
view all 10 authors...
The coronavirus disease 2019 (COVID-19) pandemic has come with many challenges for healthcare providers and patients alike. In addition to the direct burden it has placed on societies and health systems, it had a significant impact in the care of patients with chronic diseases, as healthcare resources were deployed to fight the crisis, and major travel and social restrictions were adopted. In the field of rheumatology, this has required notable efforts from departments and clinicians to adapt to...
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#1Sytske Anne Bergstra (LUMC: Leiden University Medical Center)H-Index: 6
#2Cornelia F. Allaart (LUMC: Leiden University Medical Center)H-Index: 38
Last. Tom W. J. Huizinga (LUMC: Leiden University Medical Center)H-Index: 94
view all 7 authors...
Objectives To study whether there is an association between body mass index (BMI) category and survival of various tumour necrosis factor inhibitors (TNFi) in rheumatoid arthritis (RA) patients in a real-life longitudinal international registry. Methods Data from 5230 patients with RA starting treatment with any TNFi were selected from the METEOR registry. Patients were divided into six BMI categories: 3.7% underweight, BMI 40 kg/m2. Time on treatment in the different BMI categories was compared...
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#1Naoshi Nishina (Keio: Keio University)H-Index: 7
#2Shinji Sato (Tokai University)H-Index: 21
Last. Masataka Kuwana (Nippon Medical School)H-Index: 57
view all 5 authors...
Objectives To investigate whether the onset of polymyositis (PM)/dermatomyositis (DM)-associated interstitial lung disease (ILD) is influenced by season and residence in the context of myositis-specific autoantibodies. Methods For patients with PM/DM-associated ILD enrolled in a multicentre cohort, 365 and 481 patients were eligible for seasonal and geographical analysis, respectively, based on the availability of reliable clinical information. The patients were divided into three groups: (1) an...
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#1Philippe CarronH-Index: 13
Last. Filip Van den BoschH-Index: 37
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Peripheral spondyloarthritis (pSpA) refers to a number of seemingly different spondyloarthritis subsets in which psoriatic arthritis (PsA) is the most common, and symptoms of arthritis, enthesitis or dactylitis predominate the clinical presentation. Although formal classification criteria for pSpA have been introduced in 2011, only a minority of epidemiological and clinical studies addressed this clinical entity as a separate disease. Moreover, research on outcome measures and treatment modaliti...
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#1Jean W. Liew (UW: University of Washington)H-Index: 1
#2Irvin J. Huang (UW: University of Washington)H-Index: 1
Last. Lianne S. Gensler (UCSF: University of California, San Francisco)H-Index: 19
view all 5 authors...
Objectives In axial spondyloarthritis (axSpA), higher body mass index (BMI) is associated with worse outcomes including response to biologics. Further clarity is needed on whether BMI is associated with disease activity overall, independent of treatment response. We performed a systematic review and meta-analysis to assess the association between BMI and disease activity as reported by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) or Ankylosing Spondylitis Disease Activity Scor...
1 CitationsSource
#1Sytske Anne Bergstra (LUMC: Leiden University Medical Center)H-Index: 6
#2Joy A. van der Pol (LUMC: Leiden University Medical Center)H-Index: 1
Last. Cornelia F. Allaart (LUMC: Leiden University Medical Center)H-Index: 38
view all 8 authors...
Objectives The window of opportunity (WOO) hypothesis suggests a limited time frame to stop rheumatoid arthritis (RA). We hypothesised that a WOO could either be represented by a hyperbolic (‘curved’) decline in the chance to achieve the outcome sustained drug-free remission (sDFR) over time, after which achieving sDFR is not possible anymore, or by a more gradual linear decline approaching zero chance to achieve sDFR. Methods Patients with RA (symptom duration Results In BeSt and IMPROVED, 54/2...
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#1Janet E. Pope (UWO: University of Western Ontario)H-Index: 60
Fatigue in rheumatoid arthritis is highly prevalent. It is correlated only weakly with disease activity but more so with pain, mood, personality features, poor sleep, obesity and comorbidities. Fatigue can be measured by many standardised questionnaires and more easily with a Visual Analogue Scale or numeric rating scale. Most patients with RA have some fatigue, and at least one in six have severe fatigue. Chronic pain and depressed mood are also common in RA patients with significant fatigue. I...
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#1Helga Westerlind (KI: Karolinska Institutet)H-Index: 10
#2Bénédicte Delcoigne (KI: Karolinska Institutet)H-Index: 2
Last. Johan Askling (KI: Karolinska Institutet)H-Index: 62
view all 3 authors...
Objectives To estimate the mortality among siblings of patients with rheumatoid arthritis (RA) and put any excess mortality among these in relation to the mortality among patients with RA. Methods Using prospective nation-wide registers, we identified patients diagnosed with new-onset RA 2001–2017 (n=8137), patients with prevalent RA 2006–2017 (n=25 464), matched general population comparator subjects to all RA patients (n=22 457/68 674) and full-siblings of all groups (n=28 878/91 546). We foll...
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