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Published on Jan 9, 2019in bioRxiv
Di Shao3
Estimated H-index: 3
,
Shaomin Cheng1
Estimated H-index: 1
+ 12 AuthorsXianghua Chai3
Estimated H-index: 3
Purpose: To determine the prevalence and clinical prediction factors associated with deleterious mutations among 882 high-risk Chinese individuals who underwent multigene panel testing for hereditary breast and ovarian cancer (HBOC) risk assessment. Experimental Design: Subjects were selected from individuals referred for genetic testing using a 21-gene panel (Oseq-BRCA) between January 2015 and March 2018. The distribution and prevalence of deleterious mutations were analyzed for the full cohor...
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Published on Feb 5, 2019in bioRxiv
Dia C. Beachboard1
Estimated H-index: 1
(Duke University),
Moonhee Park (Duke University)+ 3 AuthorsStacy M. Horner16
Estimated H-index: 16
(Duke University)
Nucleic acid-based antiviral innate immunity activates a signaling cascade that induces type I and type III interferons (IFNs), and other cytokines. This signaling, which is highly regulated, is initiated by pattern recognition receptors, such as RIG-I, that sense viral RNA and then signal to the adaptor protein, MAVS. This adaptor protein then recruits additional signaling proteins, including TRAF3 and TBK1, to form a signaling complex that results in IRF3 activation for transcriptional inducti...
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Published on Feb 12, 2019in bioRxiv
Ricardo F. Frausto8
Estimated H-index: 8
(University of California, Los Angeles),
D. D. Chung (University of California, Los Angeles)+ 14 AuthorsD. Wong (University of California, Los Angeles)
The zinc finger e-box binding homeobox 1 (ZEB1) transcription factor is a master regulator of the epithelial to mesenchymal transition (EMT), and of the reverse mesenchymal to epithelial transition (MET) processes. ZEB1 plays an integral role in mediating cell state transitions during cell lineage specification, wound healing and disease. EMT/MET are characterized by distinct changes in molecular and cellular phenotype that are generally context-independent. Posterior polymorphous corneal dystro...
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Published on Jan 31, 2019in bioRxiv
Nsa Dada1
Estimated H-index: 1
(Centers for Disease Control and Prevention),
Juan C. Lol1
Estimated H-index: 1
(Universidad del Valle de Guatemala)
+ 5 AuthorsAudrey Lenhart20
Estimated H-index: 20
(Centers for Disease Control and Prevention)
A deeper understanding of the mechanisms underlying insecticide resistance is needed to mitigate its threat to malaria vector control. Building upon our earlier identified associations between mosquito microbiota and insecticide resistance, we demonstrate for the first time, type-specific effects of pyrethroid exposure on internal and cuticle surface bacteria in adult progeny of field-collected Anopheles albimanus. In contrast, larval cuticle surface--but not internal--bacteria were affected by ...
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Published on Feb 24, 2019in bioRxiv
Ilona Lipp (Max Planck Society), Greg D. Parker4
Estimated H-index: 4
(Cardiff University)
+ 6 AuthorsDerek K. Jones60
Estimated H-index: 60
(Australian Catholic University)
Accurate anatomical localisation of specific white matter tracts and the quantification of their tract-specific microstructural damage in multiple sclerosis (MS) can contribute to a better understanding of symptomatology, disease progression and intervention effects. Diffusion MRI-based tractography is being used increasingly to segment white matter tracts as regions-of-interest for subsequent quantitative analysis. Since MS lesions can interrupt the tractography algorithm tract reconstruction, ...
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Published on Feb 1, 2019in bioRxiv
Amy Lewis3
Estimated H-index: 3
(University of Sheffield),
Philip M. Elks11
Estimated H-index: 11
(University of Sheffield)
Macrophage subtypes are poorly characterised in disease systems in vivo. The initial innate immune response to injury and infectious stimuli through M1 polarisation is important for the outcome of disease. Appropriate macrophage polarisation requires complex coordination of local microenvironmental cues and cytokine signalling to influence immune cell phenotypes. If the molecular mechanisms behind macrophage polarisation were better understood then macrophages could be pharmacologically tuned to...
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Published on Jan 9, 2019in bioRxiv
Leonore Wigger5
Estimated H-index: 5
(Swiss Institute of Bioinformatics),
Cristina Casals Casas1
Estimated H-index: 1
(University of Lausanne)
+ 4 AuthorsBéatrice Desvergne52
Estimated H-index: 52
(University of Lausanne)
Transcriptional regulations exert a critical control of metabolic homeostasis. In particular, the nuclear receptors (NRs) are involved in regulating numerous pathways of the intermediate metabolism. The purpose of the present study was to explore in liver cells the interconnectedness between three of them, LXR, FXR, and PPARα, all three known to act on lipid and glucose metabolism, and also on inflammation. The human cell line HepaRG was selected for its best proximity to human primary hepatocyt...
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Published on Jan 26, 2019in bioRxiv
Deepak Kumar4
Estimated H-index: 4
(Indian Institute of Technology Mandi),
Nitin Sharma4
Estimated H-index: 4
(Indian Institute of Technology Mandi)
+ 2 AuthorsRajanish Giri11
Estimated H-index: 11
(Indian Institute of Technology Mandi)
Since 2007, repeated outbreaks of Zika virus (ZIKV) has affected millions of people worldwide and created global health concern with major complications like microcephaly and Guillain Barre syndrome. Generally, ZIKV transmits through mosquitoes (Aedes aegypti) like other flaviviruses, but reports show blood transfusion and sexual mode of ZIKV transmission which further makes the situation alarming. Till date, there is not a single Zika specific licensed drug or vaccine present in the market. How...
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Published on Feb 20, 2019in bioRxiv
Dong Xiao (China University of Mining and Technology), Enyuan Wang (China University of Mining and Technology), Yidong Zhang (China University of Mining and Technology)
Organic compounds fermentation of coal has been used to generate secondary biogenic gas and enhance gas reservoirs in coalbed. To enhance the bio-degradation process, culture nutrition plays an important role in remediating the nutritional deficiency of the coal seam. The influence of bio-methane yield with organic inputs and cations concentrations was examined. Research of organic matrix influence revealed that the traditional organic material except yeast extract should forbid, and the input o...
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Published on Feb 5, 2019in bioRxiv
Heather M Briggs (University of California, Irvine), Carolyn Ayers1
Estimated H-index: 1
(Emory University)
+ 1 AuthorsBerry J. Brosi18
Estimated H-index: 18
(Emory University)
Given ongoing pollinator declines, it is important to understand the dynamics of linked extinctions of plants driven by pollinator extinctions. Topological robustness models focused on this question suggest relatively high robustness of plant species to pollinator species extinctions. Still, existing robustness models typically assume that all interactions in plant-pollinator networks are positive, which is clearly not always the case. For example, many pollinators remove floral resources with-o...
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