Match!
bioRxiv
Papers
64984
Papers 10000
1 page of 1,000 pages (10k results)
Newest
#1Van Winkle (OHSU: Oregon Health & Science University)
#5Li
Last. Nice
view all 3 authors...
Interferon (IFN) family cytokines stimulate genes (ISGs) that are integral to antiviral host defense. Type I IFNs act systemically whereas type III IFNs act preferentially at epithelial barriers. Among barrier cells, intestinal epithelial cells (IECs) are particularly dependent on type III IFN for control and clearance of virus infection, but the physiological basis of this selective IFN response is not well understood. Here, we confirm that type III IFN treatment elicits robust and uniform ISG ...
Source
#1A. Pavlin (University of Ljubljana)
Last. Matej ButalaH-Index: 10
view all 5 authors...
Acinetobacter baumannii poses a great threat in healthcare settings worldwide with clinical isolates revealing an ever evolving multidrug-resistance. Here, we report the molecular mechanisms governing the tight repression of the error-prone DNA polymerase umuDC genes in this important bacterial human pathogen. We demonstrate that the small DdrR protein directly interacts with the UmuDAb transcription repressor, which possesses some similarities to LexA proteins from other bacteria, to increase t...
Source
Last. Elizabeth L. ClareH-Index: 25
view all 7 authors...
Habitat degradation is pervasive across the tropics and is particularly acute in Southeast Asia, with major implications for biodiversity. Much research has addressed the impact of degradation on species diversity; however, little is known about how ecological interactions are altered, including those that constitute important ecosystem functions such as pest consumption. We examined how rainforest degradation alters trophic interaction networks linking insectivorous bats and their prey. We used...
Source
#1Alexander L. Nielsen (UCPH: University of Copenhagen)H-Index: 1
#2Nima RajabiH-Index: 2
Last. Christian A. OlsenH-Index: 26
view all 9 authors...
Sirtuin 2 (SIRT2) is a protein deacylase enzyme that has been reported to remove both acetyl groups and longer chain acyl groups from lysine residues in post-translationally modified proteins. It affects diverse biological functions in the cell and has been considered a drug target in relation to both neurodegenerative diseases and cancer. Therefore, access to good chemical tool compounds are essential for the continued investigation of the complex function of this enzyme. Here, we report a coll...
Source
Marine sponges live with complex microbial consortia, which have been considered as potential sources of novel natural products. However, the usual recalcitrance of host-associated microorganisms to cultivation makes studying sponge symbionts challenging. To tackle this complexity, exploration of cultivated sponge-associated bacteria and their coding potential is unavoidable. In this study, we isolate and report the draft genome sequences of 14 bacterial strains from the marine sponge Spongia sp...
Source
#1de Wet (UCT: University of Cape Town)
Last. Warner
view all 5 authors...
Mycobacterium tuberculosis possesses a large number of genes of unknown or merely predicted function, undermining fundamental understanding of pathogenicity and drug susceptibility. To address this challenge, we developed a high-throughput functional genomics approach combining inducible CRISPR-interference and image-based analyses of morphological features and sub-cellular molecular localizations in the related non-pathogen, M. smegmatis. Applying automated imaging and analysis to an arrayed li...
Source
#1Ryan R. ChengH-Index: 16
Last. José N. OnuchicH-Index: 79
view all 6 authors...
We study the structural ensembles of human chromosomes across different cell types. Using computer simulations, we generate cell-specific 3D chromosomal structures and compare them to recently published chromatin structures obtained through super-resolution microscopy. We demonstrate using a combination of machine learning and polymer physics simulations that epigenetic information can be used to predict the structural ensembles of multiple human cell lines. The chromosomal structures obtained i...
Source
#1T. Hiramatsu (Kobe University)
#2Naoki YamamotoH-Index: 21
Last. Eri ChataniH-Index: 17
view all 9 authors...
Amyloid fibrils are protein aggregates with needle-like morphology and cross-{beta} structure that are associated with amyloidoses and neurodegenerative diseases. It is recently suggested that amyloid polymorphism, i.e., structural diversity of amyloid fibrils, has a deep relationship with pathology, attracting a great deal of attention for understanding molecular mechanism of amyloid diseases. However, its prompt recognition is almost halted due to inadequate development of analytical methods f...
Source
#1Alexander YermanosH-Index: 3
#2Victor GreiffH-Index: 10
Last. Sai T. ReddyH-Index: 24
view all 5 authors...
Understanding B cell evolution following vaccination or infection is crucial for instructing targeted immunotherapies when searching for potential therapeutic or virus-neutralizing antibodies. Antibody phylogenetics holds the potential to quantify both clonal selection and somatic hypermutation, two key players shaping B cell evolution. A wide range of bioinformatic pipelines and phylogenetic inference methods have been utilized on antibody repertoire sequencing datasets to delineate B cell evol...
Source
Last. Béatrice DenoyesH-Index: 11
view all 10 authors...
Flavonoids are products from specialized metabolism that contribute to fruit sensorial (colour) and nutritional (antioxidant properties) quality. Here, using a pseudo full-sibling F1 progeny previously studied for fruit sensorial quality of cultivated strawberry (Fragaria x ananassa), we explored over two successive years the genetic architecture of flavonoid-related traits using LC-ESI-MS (13 compounds including anthocyanins, flavonols and flavan-3-ols) and colorimetric assays (anthocyanins, fl...
Source
12345678910
Top fields of study
Gene
Genetics
Bioinformatics
Biology
Cell biology