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Frontiers in Medicine
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A plan is presented for how the model can be implemented worldwide in healthcare and how novel treatments and targets can be detected. The idea is based on poikilosis, pervasive heterogeneity and variation at all levels, systems and mechanisms. Poikilosis in diseases can be taken account in pathogenicity model, which is based on distribution of three independent condition measures – extent, modulation and severity. Pathogenicity model is a population or cohort-based description of disease compon...
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#1Tao Zhang (SJTU: Shanghai Jiao Tong University)
#2Junhang Jiang (SJTU: Shanghai Jiao Tong University)
Last. Feng Qian (Bengbu Medical College)H-Index: 35
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Inflammatory bowel disease is a chronic disease that commonly accompanied by increased inflammatory responses and elevated reactive oxygen species of the gastrointestinal tract. Here, we found that MAPK-activated protein kinase 2 (MK2) modulates reactive oxygen species (ROS) production and is required for dextran sulfate sodium-induced inflammatory bowel disease in the mouse model. Genetic ablation of MK2 in the myeloid lineage cells (MK2Lyz2-KO) protected against DSS-induced colitis injury. In ...
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#1Amy X. Du (U of A: University of Alberta)H-Index: 1
#2Sepideh Emam (U of A: University of Alberta)
Last. Robert Gniadecki (U of A: University of Alberta)H-Index: 41
view all 3 authors...
Artificial intelligence is a broad branch of computer science that has garnered significant interest in the field of medicine because of its problem solving, decision making and pattern recognition abilities. Machine learning, a subset of artificial intelligence, hones in on the ability of computers to receive data and learn for themselves, manipulating algorithms as they organize the information they are processing. Dermatology is at a particular advantage in the implementation of machine learn...
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#1Hiten D. Mistry (University of Nottingham)H-Index: 14
#2Melissa V. Hott Ogalde (University of Nottingham)
Last. Lesia O. Kurlak (University of Nottingham)H-Index: 13
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Selectins (endothelial (E), platelet (P) and leucocytes (L)) are a class of cell adhesion molecules, stimulated in response to inflammation. Pre-eclampsia is characterized by inflammation, and angiotensin II is pro-inflammatory. We hypothesised that circulating maternal and fetal concentrations and placental expression of selectins would be increased in women with pre-eclampsia and would be associated with the angiotensin receptors (AT1R and AT2R). Maternal and fetal blood and placental tissue w...
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#1Jiayun Koh (NUS: National University of Singapore)
#2Shimoni Urvish Shah (NUS: National University of Singapore)
Last. Junxiong Pang (NUS: National University of Singapore)H-Index: 9
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Background: On 29th December 2019, a cluster of cases displaying the symptoms of a "pneumonia of unknown cause" was identified in Wuhan, Hubei province of China. This systematic review and meta-analysis aims to review the epidemiological & clinical characteristics of COVID-19 cases in the early phase of the COVID-19 pandemic. Methods: The search strategy involved peer-reviewed studies published between 1st January and 11th February 2020 in Pubmed, Google scholar and China Knowledge Resource Inte...
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#1Zisis KozlakidisH-Index: 8
#2Olivier VandenbergH-Index: 20
Last. John StellingH-Index: 16
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#1Tomohiro Nakamura (Rakuno Gakuen University)H-Index: 1
#2Junya Kitana (Rakuno Gakuen University)H-Index: 1
Last. Hidetomo Iwano (Rakuno Gakuen University)H-Index: 14
view all 7 authors...
The spread of antibiotic-resistant bacteria (ARB) in human and veterinary medicine is of global concern. Notably, the emergence of methicillin-resistant Staphylococcus pseudintermedius (MRSP) has become a serious problem. In this context, bacteriophages and their lytic enzymes, endolysins, have received considerable attention as therapeutics for infectious diseases in place of antibiotics. The aim of the present study was to investigate the antibiotic-resistance patterns of staphylococcal specie...
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#1Hafiz Abdul Sattar Hashmi (The Islamia University of Bahawalpur Pakistan)
#2Hafiz Muhammad Asif (The Islamia University of Bahawalpur Pakistan)H-Index: 8
Background: Since Covid-19 global pandemic emerged, developing countries are facing multiple challenges for its diagnosis. We aimed to establish a relationship between sign and symptoms of COVID-19 for early detection and assessment to reduce transmission rate of SARS-Cov-2. Methods: We collected published data on clinical features of Covid-19 retrospectively and categorized into physical and blood biomarkers. Common features were assigned scores by Borg scoring method with slight modifications ...
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