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Frontiers in Oncology
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#1Ru Chen (Kyoto University)
#2Aiko Sugiyama (Kyoto University)H-Index: 1
Last. Hiroshi Seno (Kyoto University)H-Index: 34
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Both pancreatic intraepithelial neoplasia (PanIN), a frequent precursor of pancreatic cancer, and intraductal papillary mucinous neoplasm (IPMN), a less common precursor, undergo several phases of molecular conversions and finally develop into highly malignant solid tumors with negative effects on the quality of life. We approached this long-standing issue by examining the following PanIN/IPMN cell lines derived from mouse models of pancreatic cancer: Ptf1a–Cre; KrasG12D; p53f/+ and Ptf1a–Cre; K...
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#1Lan SongH-Index: 3
Last. Zhengyu JinH-Index: 18
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#1Haiping Dai (Soochow University (Taiwan))H-Index: 3
#2Jia Yin (Soochow University (Taiwan))H-Index: 3
Last. Sheng Xiao (Brigham and Women's Hospital)H-Index: 41
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Background: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is associated with high rates of treatment failure and poor outcome. Activation of ABL/Src family kinases is found in approximately 10% of Ph-like ALL, which can be therapeutically targeted by tyrosine kinase inhibitors. LYN is a member of the ABL/Src-tyrosine kinase family. Somatic LYN rearrangements are found in 5 cases of hematopoietic malignancies so far, although none of them were treated with tyrosine kinas...
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#1Patrick Connerty (UNSW: University of New South Wales)H-Index: 1
#2Richard B. Lock (UNSW: University of New South Wales)H-Index: 47
Last. Charles E. de Bock (UNSW: University of New South Wales)H-Index: 16
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Cellular stress can occur in many forms; oxidative stress caused by reactive oxygen species (ROS), metabolic stress from increased metabolic programs and genotoxic stress in the form of DNA damage and disrepair. In most instances, these different types of cell stress initiate programmed cell death. However, in cancer, cells are able to resist cellular stress and by-pass growth limiting checkpoints. Recent findings have now revealed that the large and heterogenous RNA species known as long non-co...
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Last. Ming Chen (CAS: Chinese Academy of Sciences)
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Abstract Purpose: Both 12-months and 6-months of trastuzumab in combination with chemotherapy are effective for HER2+ early-stage breast cancer. This meta-analysis was performed to assess the effectiveness and toxicity of the two durations. Methods and Materials: We acquired relevant randomized controlled trials (RCTs) from PubMed, the Cochrane Library, ScienceDirect, EMBASE, Ovid MEDLINE, Web of Science, Scopus, and Google Scholar. Our endpoints included disease-free survival (DFS), overall sur...
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#1Jihyoun Lee (SCH: Soonchunhyang University)H-Index: 7
#2Heba M. Alqudaihi (UOU: University of Ulsan)
Last. Sun Wook Han (SCH: Soonchunhyang University)H-Index: 6
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Background Although international guidelines recommend bone screening for premenopausal breast cancer patients taking adjuvant tamoxifen, the effects of tamoxifen on osteoporosis and related risks remain controversial. The objective of this study was to investigate the incidence of and risk factors for osteoporosis and osteoporotic fractures in younger breast cancer patients. Methods A nationwide retrospective cohort study was conducted using South Korea Health Insurance Review and Assessment Se...
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#1Jian Zhou (Fudan University)H-Index: 74
#2Liang Zhou (Fudan University)H-Index: 49
Last. Yong Yu (Wellcome Trust Sanger Institute)H-Index: 7
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Background: We report functional and clinical data uncovering the significance of B-cell lymphoma/leukaemia 11A (BCL11A) in laryngeal squamous cell carcinoma (LSCC). Methods: We examined BCL11A expression in a cohort of LSCC patients and evaluated the association between BCL11A expression and clinicopathological features. We investigated the consequences of overexpressing BCL11A in the LSCC cell line on proliferation, migration, invasion, cell cycle, chemosensitivity and growth in vivo. We explo...
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#1Heba Alshaker (UEA: University of East Anglia)H-Index: 10
#2Hannah Thrower (Imperial College London)
Last. Dmitri Pchejetski (UEA: University of East Anglia)H-Index: 11
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It is now well established that sphingosine kinase 1 (SK1) plays a significant role in breast cancer development, progression, and spread, whereas SK1 knockdown can reverse these processes. In breast cancer cells and tumours SK1 was shown to interact with various pathways involved in cell survival and chemoresistance, such as nuclear factor-kappa B (NFκB), Notch, Ras/MAPK, PKC and PI3K. SK1 is upregulated by oestrogen signalling which in turn confers cancer cells with resistance to tamoxifen. Sp...
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