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Frontiers in Oncology
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Secreted phosphoprotein-1 (SPP1) has been reported to be involved in the pathogenesis of breast cancer (BRC), but the influence of SPP1 SNPs on the BRC susceptibility has been rarely reported. In this study, we explored the association between rs11730582, rs2853750 and rs35893069 in the SPP1 gene and the BRC susceptibility. We used Snapshot assay to detect SPP1 SNPs in 471 BRC patients and 471 controls. The plasma SPP1 level was measured by enzyme-linked immunosorbent assay (ELISA). We found tha...
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Abstract The current approach to systemic therapy for metastatic cancer is aimed predominantly at inducing apoptosis of cancer cells by blocking tumor-promoting signaling pathways or by eradicating cell compartments within the tumor. In contrast, a systems view of therapy primarily considers the communication protocols that exist at multiple levels within the tumor complex, and the role of key regulators of such systems. Such regulators may have far-reaching influence on tumor response to therap...
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Top fields of study
Cancer
Pathology
Immunology
Cancer research
Medicine